DegronMD

Uniprot ID: Q6NUJ5

Source protein: PWWP domain-containing protein 2B

Source gene: PWWP2B

Class: DEG_Kelch_Keap1_1

Location: 382:387

E3 ligase: KEAP1

DEGRON score: 0.9831

ASA_SCORE: 69.65

COIL: 0.852

CONS_SCORE: 0.5486

DSS_SCORE: 0.5821

HELIX: 0.0937

FCONS_SCORE: 1.0336

RIG_SCORE: 0.5354

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E387K	TCGA-18-3414	LUSC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	0.7022
p.E387K	DO26629	LUSC	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.7022
p.S382F	TCGA-GN-A26C	SKCM	TCGA	SGSSGE	DEG_Kelch_Keap1_1	0.7982
p.S382F	DO37782	SKCM	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.7982
p.S381P	TCGA-IB-7651	PAAD	TCGA	SGSSGE	DEG_Kelch_Keap1_1	0.3056
p.S381P	DO46657	PAAD	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.3056
p.S385L	TCGA-YD-A9TA	SKCM	TCGA	SGSSGE	DEG_Kelch_Keap1_1	0.7667
p.S385L	DO219503	SKCM	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.7667
p.G375S	DO35442	PACA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.1389
p.G375S	SIDM02071	Esophageal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.1389
p.G397S	SIDM01096	Colorectal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.0556
p.G397S	SIDM01109	Other Sarcomas	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.0556
p.G397S	SIDM00081	Melanoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.0556
p.G397S	SIDM01475	Ovarian Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.0556
p.G397S	SK-CO-1	large_intestine	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	0.0556
p.G397D	SIDM00684	Glioblastoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.0556
p.G397D	SIDM00555	Glioblastoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.0556
p.G397D	ACH-000595	Brain Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	0.0556
p.G397D	ACH-000631	Brain Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	0.0556
p.G397D	KS-1	central_nervous_system	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	0.0556
p.G397D	LN-229	central_nervous_system	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	0.0556
p.P395R	SIDM00002	Neuroblastoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.1111
p.P395R	ACH-002340	Neuroblastoma	CCLE	SGSSGE	DEG_Kelch_Keap1_1	0.1111
p.P395R	NBsusSR	autonomic_ganglia	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	0.1111
p.G376R	ACH-001282	Bone Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35716	Transcription factor SOX-11	DEG_Kelch_Keap1_1	351:356	SGSSGE	KEAP1	0.9388	More...
Q02156	Protein kinase C epsilon type	DEG_Kelch_Keap1_1	132:137	SGSSGE	KEAP1	0.8528	More...
Q9UGU5	HMG domain-containing protein 4	DEG_Kelch_Keap1_1	153:158	SGSSGE	KEAP1	0.9956	More...
Q6NUJ5	PWWP domain-containing protein 2B	DEG_Kelch_Keap1_1	382:387	SGSSGE	KEAP1	0.9831	More...
Q9NZL6	Ral guanine nucleotide dissociation stimulator-like 1	DEG_Kelch_Keap1_1	544:549	SGSSGE	KEAP1	0.965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SGSSGE

Degron related mutations and impact score

Drug responses associated with PWWP2B mutations

All proteins holding degron of SGSSGE