DegronMD - Q9UGU5(HMGXB4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K168E	TCGA-VQ-A91D	STAD	TCGA	SGSSGE	DEG_Kelch_Keap1_1	153:158	Mutation substituting flanking lysine	0.1667
p.K168E	DO51783	STAD	ICGC	SGSSGE	DEG_Kelch_Keap1_1	153:158	Mutation substituting flanking lysine	0.1667
p.G165V	DO229013	COCA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	153:158	Mutation rewiring degron network	0.1389
p.G165V	DO229016	COCA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	153:158	Mutation rewiring degron network	0.1389
p.G165V	DO229003	COCA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	153:158	Mutation rewiring degron network	0.1389
p.G165V	DO229505	LAML	ICGC	SGSSGE	DEG_Kelch_Keap1_1	153:158	Mutation rewiring degron network	0.1389
p.G165V	DO230659	LAML	ICGC	SGSSGE	DEG_Kelch_Keap1_1	153:158	Mutation rewiring degron network	0.1389
p.G165V	DO231140	LAML	ICGC	SGSSGE	DEG_Kelch_Keap1_1	153:158	Mutation rewiring degron network	0.1389
p.G165V	DO231075	LUSC	ICGC	SGSSGE	DEG_Kelch_Keap1_1	153:158	Mutation rewiring degron network	0.1389
p.G165V	DO231212	LUSC	ICGC	SGSSGE	DEG_Kelch_Keap1_1	153:158	Mutation rewiring degron network	0.1389
p.E146D	DO229045	LICA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	153:158	Mutation rewiring degron network	0.1389
p.K150N	SIDM00025	Head and Neck Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	153:158	Mutation substituting flanking lysine	0.3611
p.K150N	ACH-002391	Head and Neck Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	153:158	Mutation substituting flanking lysine	0.3611
p.K150N	UDSCC2	upper aerodigestive tract	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	153:158	Mutation substituting flanking lysine	0.3611
p.G164D	SIDM00217	Colorectal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	153:158	Mutation rewiring degron network	0.1667
p.G164D	ACH-000999	Colon/Colorectal Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	153:158	Mutation rewiring degron network	0.1667
p.G164D	SNU-1040	large intestine	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	153:158	Mutation rewiring degron network	0.1667

Kaplan plot for HMGXB4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HMGXB4

UniProt ID: Q9UGU5

Entrez ID: 10042

Protein name: HMG domain-containing protein 4 (HMG box-containing protein 4) (High mobility group protein 2-like 1) (Protein HMGBCG)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HMGXB4 in