DegronMD

Uniprot ID: Q9UGU5

Source protein: HMG domain-containing protein 4

Source gene: HMGXB4

Class: DEG_Kelch_Keap1_1

Location: 153:158

E3 ligase: KEAP1

DEGRON score: 0.9956

ASA_SCORE: 81.6

COIL: 0.9345

CONS_SCORE: 0.4423

DSS_SCORE: 0.7292

HELIX: 0.0392

FCONS_SCORE: 1.028

RIG_SCORE: 0.5198

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K168E	TCGA-VQ-A91D	STAD	TCGA	SGSSGE	DEG_Kelch_Keap1_1	0.1667
p.K168E	DO51783	STAD	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.1667
p.G165V	DO229013	COCA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.1389
p.G165V	DO229016	COCA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.1389
p.G165V	DO229003	COCA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.1389
p.G165V	DO229505	LAML	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.1389
p.G165V	DO230659	LAML	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.1389
p.G165V	DO231140	LAML	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.1389
p.G165V	DO231075	LUSC	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.1389
p.G165V	DO231212	LUSC	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.1389
p.E146D	DO229045	LICA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.1389
p.K150N	SIDM00025	Head and Neck Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.3611
p.K150N	ACH-002391	Head and Neck Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	0.3611
p.K150N	UDSCC2	upper_aerodigestive_tract	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	0.3611
p.G164D	SIDM00217	Colorectal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.1667
p.G164D	ACH-000999	Colon/Colorectal Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	0.1667
p.G164D	SNU-1040	large_intestine	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35716	Transcription factor SOX-11	DEG_Kelch_Keap1_1	351:356	SGSSGE	KEAP1	0.9388	More...
Q02156	Protein kinase C epsilon type	DEG_Kelch_Keap1_1	132:137	SGSSGE	KEAP1	0.8528	More...
Q9UGU5	HMG domain-containing protein 4	DEG_Kelch_Keap1_1	153:158	SGSSGE	KEAP1	0.9956	More...
Q6NUJ5	PWWP domain-containing protein 2B	DEG_Kelch_Keap1_1	382:387	SGSSGE	KEAP1	0.9831	More...
Q9NZL6	Ral guanine nucleotide dissociation stimulator-like 1	DEG_Kelch_Keap1_1	544:549	SGSSGE	KEAP1	0.965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons