DegronMD

Uniprot ID: Q9NZL6

Source protein: Ral guanine nucleotide dissociation stimulator-like 1

Source gene: RGL1

Class: DEG_Kelch_Keap1_1

Location: 544:549

E3 ligase: KEAP1

DEGRON score: 0.965

ASA_SCORE: 67.3167

COIL: 0.9202

CONS_SCORE: 0.2871

DSS_SCORE: 0.705

HELIX: 0.0418

FCONS_SCORE: 0.8738

RIG_SCORE: 0.506

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D538V	TCGA-73-4666	LUAD	TCGA	SGSSGE	DEG_Kelch_Keap1_1	0.1667
p.S540I	TCGA-A5-A0G1	UCEC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	0.3333
p.A539T	TCGA-A5-A0G2	UCEC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	0.1944
p.R547L	TCGA-B5-A1MR	UCEC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	0.8428
p.R547W	TCGA-CV-7440	HNSC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	0.8634
p.P544A	TCGA-DF-A2KU	UCEC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	0.7503
p.R553I	TCGA-EO-A22U	UCEC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	0.2222
p.V556M	DO234332	ESAD	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.1389
p.V556M	DO36773	READ	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.1389
p.K540R	DO233897	GACA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.3333
p.C559F	DO228978	LICA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.0556
p.V556L	DO229015	LICA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.1389
p.S547C	DO27381	LUSC	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.7541
p.S550T	DO30490	OV	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.3056
p.K540M	DO48016	STAD	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.3333
p.G548C	DO229229	THCA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.76
p.S555N	SIDM02035	Colorectal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.1667
p.L557V	SIDM00777	Colorectal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.1111
p.L557V	NCI-H508	large_intestine	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	0.1111
p.L559V	SIDM00281	Other Solid Cancers	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.0556
p.L559V	ACH-002100	Skin Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	0.0556
p.L559V	DJM-1	skin	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	0.0556
p.P546H	SIDM00789	Colorectal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.7694
p.P546H	ACH-000997	Colon/Colorectal Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	0.7694
p.P546H	HCT-15	large_intestine	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	0.7694
p.S549N	SIDM00193	Colorectal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.7069
p.S549N	ACH-000991	Colon/Colorectal Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	0.7069
p.S549N	SNU-81	large_intestine	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	0.7069
p.S546T	TE-11	oesophagus	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35716	Transcription factor SOX-11	DEG_Kelch_Keap1_1	351:356	SGSSGE	KEAP1	0.9388	More...
Q02156	Protein kinase C epsilon type	DEG_Kelch_Keap1_1	132:137	SGSSGE	KEAP1	0.8528	More...
Q9UGU5	HMG domain-containing protein 4	DEG_Kelch_Keap1_1	153:158	SGSSGE	KEAP1	0.9956	More...
Q6NUJ5	PWWP domain-containing protein 2B	DEG_Kelch_Keap1_1	382:387	SGSSGE	KEAP1	0.9831	More...
Q9NZL6	Ral guanine nucleotide dissociation stimulator-like 1	DEG_Kelch_Keap1_1	544:549	SGSSGE	KEAP1	0.965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SGSSGE

Degron related mutations and impact score

Drug responses associated with RGL1 mutations

All proteins holding degron of SGSSGE