DegronMD - Q9NZL6(RGL1)

FUNCTION: Probable guanine nucleotide exchange factor.

GO - Biological processes (BP): positive regulation of GTPase activity [GO:0043547]; Ras protein signal transduction [GO:0007265]; small GTPase mediated signal transduction [GO:0007264]

GO - Molecular function (MF): guanyl-nucleotide exchange factor activity [GO:0005085]

GO - Cellular component (CC): cytosol [GO:0005829]; plasma membrane [GO:0005886]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R547W	TCGA-CV-7440	HNSC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.8634
p.R547L	TCGA-B5-A1MR	UCEC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.8428
p.R518I	DO43755	UCEC	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation altering degron motif	0.8102
p.K575M	TCGA-FP-A4BE	STAD	TCGA	ITPMDT	DEG_SCF_FBW7_1	571:576	Mutation altering degron motif	0.8062
p.P546H	SIDM00789	Colorectal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.7694
p.P546H	ACH-000997	Colon/Colorectal Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.7694
p.P546H	HCT-15	large intestine	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.7694
p.G548C	DO229229	THCA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.76
p.S547C	DO27381	LUSC	ICGC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.7541
p.P544A	TCGA-DF-A2KU	UCEC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.7503
p.S526P	DO220176	SARC	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation blocking phosphorylation signal	0.75
p.S526N	SIDM00516	Melanoma	GDSC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation blocking phosphorylation signal	0.75
p.S526N	MZ7-mel	skin	COSMIC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation blocking phosphorylation signal	0.75
p.S520R	DO233888	GACA	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation altering degron motif	0.7427
p.E534G	TCGA-EO-A22R	UCEC	TCGA	PTPTKE	DEG_SCF_FBW7_2	532:537	Mutation altering degron motif	0.7199
p.S546T	TE-11	oesophagus	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.7116
p.S520N	DO42673	UCEC	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation altering degron motif	0.7069
p.S549N	SIDM00193	Colorectal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.7069
p.S549N	ACH-000991	Colon/Colorectal Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.7069
p.S549N	SNU-81	large intestine	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.7069

Showing 1 to 20 of 95 entries

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Kaplan plot for RGL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RGL1

UniProt ID: Q9NZL6

Entrez ID: 23179

Protein name: Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RGL1 in