DegronMD - Q9NZL6(RGL1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D633G	TCGA-06-5416	GBM	TCGA	PPVY	ITCH	639:642	Mutation rewiring degron network	0.1667
p.S585T	TCGA-13-0885	OV	TCGA	ITPMDT	DEG_SCF_FBW7_1	571:576	Mutation rewiring degron network	0.0833
p.S648F	TCGA-3N-A9WC	SKCM	TCGA	PPVY	ITCH	639:642	Mutation rewiring degron network	0.1667
p.S582C	TCGA-52-7810	LUSC	TCGA	ITPMDT	DEG_SCF_FBW7_1	571:576	Mutation substituting flanking lysine	0.2778
p.S636F	TCGA-55-1592	LUAD	TCGA	PPVY	ITCH	639:642	Mutation rewiring degron network	0.25
p.S636F	TCGA-ER-A19W	SKCM	TCGA	PPVY	ITCH	639:642	Mutation rewiring degron network	0.25
p.S636F	ACH-002508	Skin Cancer	CCLE	PPVY	ITCH	639:642	Mutation rewiring degron network	0.25
p.Y527D	TCGA-5P-A9JW	KIRP	TCGA	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation rewiring degron network	0.2778
p.Y527D	TCGA-5P-A9JW	KIRP	TCGA	PTPTKE	DEG_SCF_FBW7_2	532:537	Mutation rewiring degron network	0.1944
p.D538V	TCGA-73-4666	LUAD	TCGA	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation rewiring degron network	0.1667
p.D538V	TCGA-73-4666	LUAD	TCGA	PTPTKE	DEG_SCF_FBW7_2	532:537	Mutation rewiring degron network	0.3056
p.S647C	TCGA-77-A5GB	LUSC	TCGA	PPVY	ITCH	639:642	Mutation rewiring degron network	0.1944
p.S540I	TCGA-A5-A0G1	UCEC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation substituting flanking lysine	0.3333
p.S540I	TCGA-A5-A0G1	UCEC	TCGA	PTPTKE	DEG_SCF_FBW7_2	532:537	Mutation substituting flanking lysine	0.3611
p.A539T	TCGA-A5-A0G2	UCEC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation rewiring degron network	0.1944
p.A539T	TCGA-A5-A0G2	UCEC	TCGA	PTPTKE	DEG_SCF_FBW7_2	532:537	Mutation rewiring degron network	0.2778
p.G638R	TCGA-AL-7173	KIRP	TCGA	PPVY	ITCH	639:642	Mutation rewiring degron network	0.3056
p.G638R	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PPVY	ITCH	639:642	Mutation rewiring degron network	0.3056
p.G638R	ACH-000980	Lung Cancer	CCLE	PPVY	ITCH	639:642	Mutation rewiring degron network	0.3056
p.G638R	NCI-H1155	lung	COSMIC	PPVY	ITCH	639:642	Mutation rewiring degron network	0.3056
p.R547L	TCGA-B5-A1MR	UCEC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.8428
p.T565A	TCGA-CG-5721	STAD	TCGA	ITPMDT	DEG_SCF_FBW7_1	571:576	Mutation rewiring degron network	0.1667
p.R547W	TCGA-CV-7440	HNSC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.8634
p.P544A	TCGA-DF-A2KU	UCEC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.7503
p.E534G	TCGA-EO-A22R	UCEC	TCGA	PTPTKE	DEG_SCF_FBW7_2	532:537	Mutation altering degron motif	0.7199
p.R553I	TCGA-EO-A22U	UCEC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation rewiring degron network	0.2222
p.D633N	TCGA-ER-A193	SKCM	TCGA	PPVY	ITCH	639:642	Mutation rewiring degron network	0.1667
p.K575M	TCGA-FP-A4BE	STAD	TCGA	ITPMDT	DEG_SCF_FBW7_1	571:576	Mutation altering degron motif	0.8062
p.P650S	TCGA-GN-A266	SKCM	TCGA	PPVY	ITCH	639:642	Mutation rewiring degron network	0.1111
p.H630Y	TCGA-GN-A4U7	SKCM	TCGA	PPVY	ITCH	639:642	Mutation rewiring degron network	0.0833
p.S561P	TCGA-IW-A3M5	SARC	TCGA	ITPMDT	DEG_SCF_FBW7_1	571:576	Mutation rewiring degron network	0.0556
p.V556M	DO234332	ESAD	ICGC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation rewiring degron network	0.1389
p.V556M	DO36773	READ	ICGC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation rewiring degron network	0.1389
p.S520R	DO233888	GACA	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation altering degron motif	0.7427
p.K540R	DO233897	GACA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation substituting flanking lysine	0.3333
p.K540R	DO233897	GACA	ICGC	PTPTKE	DEG_SCF_FBW7_2	532:537	Mutation substituting flanking lysine	0.3611
p.T631M	DO44440	HNSC	ICGC	PPVY	ITCH	639:642	Mutation rewiring degron network	0.1111
p.T631M	DO38192	STAD	ICGC	PPVY	ITCH	639:642	Mutation rewiring degron network	0.1111
p.R512W	DO15078	HNSC	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation rewiring degron network	0.1944
p.N646K	DO44511	KIRP	ICGC	PPVY	ITCH	639:642	Mutation rewiring degron network	0.2222
p.E567D	DO228952	LICA	ICGC	ITPMDT	DEG_SCF_FBW7_1	571:576	Mutation rewiring degron network	0.2222
p.E567D	LNCaP-Clone-FGC	prostate	COSMIC	ITPMDT	DEG_SCF_FBW7_1	571:576	Mutation rewiring degron network	0.2222
p.C559F	DO228978	LICA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation rewiring degron network	0.0556
p.V556L	DO229015	LICA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation rewiring degron network	0.1389
p.N562K	DO224566	LUSC	ICGC	ITPMDT	DEG_SCF_FBW7_1	571:576	Mutation rewiring degron network	0.0833
p.N562K	DO231007	LUSC	ICGC	ITPMDT	DEG_SCF_FBW7_1	571:576	Mutation rewiring degron network	0.0833
p.S629L	DO26438	LUSC	ICGC	PPVY	ITCH	639:642	Mutation rewiring degron network	0.0556
p.S629L	SNU-81	large intestine	COSMIC	PPVY	ITCH	639:642	Mutation rewiring degron network	0.0556
p.S547C	DO27381	LUSC	ICGC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.7541
p.S550T	DO30490	OV	ICGC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation rewiring degron network	0.3056
p.C650Y	DO51540	PACA	ICGC	PPVY	ITCH	639:642	Mutation rewiring degron network	0.1111
p.I651R	DO229582	PRAD	ICGC	PPVY	ITCH	639:642	Mutation rewiring degron network	0.0833
p.S526P	DO220176	SARC	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation blocking phosphorylation signal	0.75
p.S526P	DO220176	SARC	ICGC	PTPTKE	DEG_SCF_FBW7_2	532:537	Mutation blocking phosphorylation signal	0.6111
p.S570F	DO37679	SKCM	ICGC	ITPMDT	DEG_SCF_FBW7_1	571:576	Mutation rewiring degron network	0.3056
p.G525W	DO37439	SKCM	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation altering degron motif	0.6714
p.K540M	DO48016	STAD	ICGC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation substituting flanking lysine	0.3333
p.K540M	DO48016	STAD	ICGC	PTPTKE	DEG_SCF_FBW7_2	532:537	Mutation substituting flanking lysine	0.3611
p.E579G	DO47973	STAD	ICGC	ITPMDT	DEG_SCF_FBW7_1	571:576	Mutation rewiring degron network	0.25
p.T530A	DO38192	STAD	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation rewiring degron network	0.1944
p.T530A	DO38192	STAD	ICGC	PTPTKE	DEG_SCF_FBW7_2	532:537	Mutation rewiring degron network	0.2778
p.S632Y	DO229211	THCA	ICGC	PPVY	ITCH	639:642	Mutation rewiring degron network	0.1389
p.G548C	DO229229	THCA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.76
p.K583N	DO39421	THCA	ICGC	ITPMDT	DEG_SCF_FBW7_1	571:576	Mutation substituting flanking lysine	0.25
p.P509A	DO223286	UCEC	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation rewiring degron network	0.1111
p.T636N	DO223286	UCEC	ICGC	PPVY	ITCH	639:642	Mutation rewiring degron network	0.25
p.R512L	DO41758	UCEC	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation rewiring degron network	0.1944
p.R518I	DO43755	UCEC	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation altering degron motif	0.8102
p.S520N	DO42673	UCEC	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation altering degron motif	0.7069
p.S555N	SIDM02035	Colorectal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation rewiring degron network	0.1667
p.L557V	SIDM00777	Colorectal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation rewiring degron network	0.1111
p.L557V	NCI-H508	large intestine	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation rewiring degron network	0.1111
p.L559V	SIDM00281	Other Solid Cancers	GDSC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation rewiring degron network	0.0556
p.L559V	ACH-002100	Skin Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation rewiring degron network	0.0556
p.L559V	DJM-1	skin	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation rewiring degron network	0.0556
p.P546H	SIDM00789	Colorectal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.7694
p.P546H	ACH-000997	Colon/Colorectal Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.7694
p.P546H	HCT-15	large intestine	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.7694
p.S549N	SIDM00193	Colorectal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.7069
p.S549N	ACH-000991	Colon/Colorectal Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.7069
p.S549N	SNU-81	large intestine	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.7069
p.S581T	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	ITPMDT	DEG_SCF_FBW7_1	571:576	Mutation rewiring degron network	0.1944
p.S581T	ACH-000488	Esophageal Cancer	CCLE	ITPMDT	DEG_SCF_FBW7_1	571:576	Mutation rewiring degron network	0.1944
p.S581T	TE-11	oesophagus	COSMIC	ITPMDT	DEG_SCF_FBW7_1	571:576	Mutation rewiring degron network	0.1944
p.S526N	SIDM00516	Melanoma	GDSC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation blocking phosphorylation signal	0.75
p.S526N	SIDM00516	Melanoma	GDSC	PTPTKE	DEG_SCF_FBW7_2	532:537	Mutation blocking phosphorylation signal	0.6111
p.S526N	MZ7-mel	skin	COSMIC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation blocking phosphorylation signal	0.75
p.S526N	MZ7-mel	skin	COSMIC	PTPTKE	DEG_SCF_FBW7_2	532:537	Mutation blocking phosphorylation signal	0.6111
p.P649H	ACH-000937	Leukemia	CCLE	PPVY	ITCH	639:642	Mutation rewiring degron network	0.1389
p.L522V	NCI-H508	large intestine	COSMIC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation altering degron motif	0.5654
p.S546T	TE-11	oesophagus	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	544:549	Mutation altering degron motif	0.7116
p.Q644K	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PPVY	ITCH	639:642	Mutation rewiring degron network	0.2778
p.L524V	DJM-1	skin	COSMIC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation altering degron motif	0.5654
p.S514N	SNU-81	large intestine	COSMIC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation rewiring degron network	0.25
p.P511H	HCT-15	large intestine	COSMIC	KRLSLLFLG	DEG_APCC_DBOX_1	517:525	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RGL1

UniProt ID: Q9NZL6

Entrez ID: 23179

Protein name: Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RGL1 in