DegronMD

Uniprot ID: Q9NZL6

Source protein: Ral guanine nucleotide dissociation stimulator-like 1

Source gene: RGL1

Class: DEG_APCC_DBOX_1

Location: 517:525

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7626

ASA_SCORE: 85.4

COIL: 0.5429

CONS_SCORE: 0.3081

DSS_SCORE: 0.4343

HELIX: 0.4009

FCONS_SCORE: 0.9788

RIG_SCORE: 0.7971

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y527D	TCGA-5P-A9JW	KIRP	TCGA	KRLSLLFLG	DEG_APCC_DBOX_1	0.2778
p.S520R	DO233888	GACA	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	0.7427
p.R512W	DO15078	HNSC	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	0.1944
p.S526P	DO220176	SARC	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	0.75
p.G525W	DO37439	SKCM	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	0.6714
p.T530A	DO38192	STAD	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	0.1944
p.P509A	DO223286	UCEC	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	0.1111
p.R512L	DO41758	UCEC	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	0.1944
p.R518I	DO43755	UCEC	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	0.8102
p.S520N	DO42673	UCEC	ICGC	KRLSLLFLG	DEG_APCC_DBOX_1	0.7069
p.S526N	SIDM00516	Melanoma	GDSC	KRLSLLFLG	DEG_APCC_DBOX_1	0.75
p.S526N	MZ7-mel	skin	COSMIC	KRLSLLFLG	DEG_APCC_DBOX_1	0.75
p.L522V	NCI-H508	large_intestine	COSMIC	KRLSLLFLG	DEG_APCC_DBOX_1	0.5654
p.L524V	DJM-1	skin	COSMIC	KRLSLLFLG	DEG_APCC_DBOX_1	0.5654
p.S514N	SNU-81	large_intestine	COSMIC	KRLSLLFLG	DEG_APCC_DBOX_1	0.25
p.P511H	HCT-15	large_intestine	COSMIC	KRLSLLFLG	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZL6	Ral guanine nucleotide dissociation stimulator-like 1	DEG_APCC_DBOX_1	517:525	KRLSLLFLG	APC,CDC20,FZR1	0.7626	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons