DegronMD

Uniprot ID: Q9NZL6

Source protein: Ral guanine nucleotide dissociation stimulator-like 1

Source gene: RGL1

Class: DEG_SCF_FBW7_1

Location: 571:576

E3 ligase: FBXW7

DEGRON score: 0.9668

ASA_SCORE: 72.15

COIL: 0.9138

CONS_SCORE: 0.293

DSS_SCORE: 0.804

HELIX: 0.0312

FCONS_SCORE: 0.9506

RIG_SCORE: 0.6288

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S585T	TCGA-13-0885	OV	TCGA	ITPMDT	DEG_SCF_FBW7_1	0.0833
p.S582C	TCGA-52-7810	LUSC	TCGA	ITPMDT	DEG_SCF_FBW7_1	0.2778
p.T565A	TCGA-CG-5721	STAD	TCGA	ITPMDT	DEG_SCF_FBW7_1	0.1667
p.K575M	TCGA-FP-A4BE	STAD	TCGA	ITPMDT	DEG_SCF_FBW7_1	0.8062
p.S561P	TCGA-IW-A3M5	SARC	TCGA	ITPMDT	DEG_SCF_FBW7_1	0.0556
p.E567D	DO228952	LICA	ICGC	ITPMDT	DEG_SCF_FBW7_1	0.2222
p.E567D	LNCaP-Clone-FGC	prostate	COSMIC	ITPMDT	DEG_SCF_FBW7_1	0.2222
p.N562K	DO224566	LUSC	ICGC	ITPMDT	DEG_SCF_FBW7_1	0.0833
p.N562K	DO231007	LUSC	ICGC	ITPMDT	DEG_SCF_FBW7_1	0.0833
p.S570F	DO37679	SKCM	ICGC	ITPMDT	DEG_SCF_FBW7_1	0.3056
p.E579G	DO47973	STAD	ICGC	ITPMDT	DEG_SCF_FBW7_1	0.25
p.K583N	DO39421	THCA	ICGC	ITPMDT	DEG_SCF_FBW7_1	0.25
p.S581T	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	ITPMDT	DEG_SCF_FBW7_1	0.1944
p.S581T	ACH-000488	Esophageal Cancer	CCLE	ITPMDT	DEG_SCF_FBW7_1	0.1944
p.S581T	TE-11	oesophagus	COSMIC	ITPMDT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZL6	Ral guanine nucleotide dissociation stimulator-like 1	DEG_SCF_FBW7_1	571:576	ITPMDT	FBXW7	0.9668	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons