DegronMD

Uniprot ID: Q9NZL6

Source protein: Ral guanine nucleotide dissociation stimulator-like 1

Source gene: RGL1

Class: DEG_SCF_FBW7_2

Location: 532:537

E3 ligase: FBXW7

DEGRON score: 0.6636

ASA_SCORE: 96.9667

COIL: 0.9102

CONS_SCORE: 0.3141

DSS_SCORE: 0.6766

HELIX: 0.0505

FCONS_SCORE: 0.9745

RIG_SCORE: 0.6554

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y527D	TCGA-5P-A9JW	KIRP	TCGA	PTPTKE	DEG_SCF_FBW7_2	0.1944
p.D538V	TCGA-73-4666	LUAD	TCGA	PTPTKE	DEG_SCF_FBW7_2	0.3056
p.S540I	TCGA-A5-A0G1	UCEC	TCGA	PTPTKE	DEG_SCF_FBW7_2	0.3611
p.A539T	TCGA-A5-A0G2	UCEC	TCGA	PTPTKE	DEG_SCF_FBW7_2	0.2778
p.E534G	TCGA-EO-A22R	UCEC	TCGA	PTPTKE	DEG_SCF_FBW7_2	0.7199
p.K540R	DO233897	GACA	ICGC	PTPTKE	DEG_SCF_FBW7_2	0.3611
p.S526P	DO220176	SARC	ICGC	PTPTKE	DEG_SCF_FBW7_2	0.6111
p.K540M	DO48016	STAD	ICGC	PTPTKE	DEG_SCF_FBW7_2	0.3611
p.T530A	DO38192	STAD	ICGC	PTPTKE	DEG_SCF_FBW7_2	0.2778
p.S526N	SIDM00516	Melanoma	GDSC	PTPTKE	DEG_SCF_FBW7_2	0.6111
p.S526N	MZ7-mel	skin	COSMIC	PTPTKE	DEG_SCF_FBW7_2	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZL6	Ral guanine nucleotide dissociation stimulator-like 1	DEG_SCF_FBW7_2	532:537	PTPTKE	FBXW7	0.6636	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons