DegronMD

Uniprot ID: Q02156

Source protein: Protein kinase C epsilon type

Source gene: PRKCE

Class: DEG_Kelch_Keap1_1

Location: 132:137

E3 ligase: KEAP1

DEGRON score: 0.8528

ASA_SCORE: 63.6167

COIL: 0.8127

CONS_SCORE: 0.25

DSS_SCORE: 0.4121

HELIX: 0.0462

FCONS_SCORE: 0.6917

RIG_SCORE: 0.6048

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L131I	TCGA-A5-A2K5	UCEC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	0.3056
p.L131I	TCGA-EO-A22R	UCEC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	0.3056
p.L131I	DO42713	UCEC	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.3056
p.L131I	DO41379	UCEC	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.3056
p.S135L	TCGA-A7-A13F	BRCA	TCGA	SGSSGE	DEG_Kelch_Keap1_1	0.7667
p.S135L	DO4098	BRCA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.7667
p.D130N	TCGA-B5-A11E	UCEC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	0.2778
p.D130N	TCGA-B5-A3FA	UCEC	TCGA	SGSSGE	DEG_Kelch_Keap1_1	0.2778
p.D130N	DO52402	UCEC	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.2778
p.D130N	DO41644	UCEC	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.2778
p.R145C	TCGA-XK-AAIW	PRAD	TCGA	SGSSGE	DEG_Kelch_Keap1_1	0.1111
p.R145C	DO51407	PRAD	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.1111
p.R145C	ACH-000152	Brain Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	0.1111
p.D141Y	DO229027	LICA	ICGC	SGSSGE	DEG_Kelch_Keap1_1	0.2222
p.S132L	SIDM02060	Pancreatic Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.7667
p.K140R	SIDM00789	Colorectal Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.3611
p.K140R	ACH-000997	Colon/Colorectal Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	0.3611
p.K140R	ACH-001061	Colon/Colorectal Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	0.3611
p.K140R	HCT-15	large_intestine	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	0.3611
p.F147L	SIDM00251	Gastric Carcinoma	GDSC	SGSSGE	DEG_Kelch_Keap1_1	0.0556
p.F147L	ACH-000949	Gastric Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	0.0556
p.F147L	TGBC11TKB	stomach	COSMIC	SGSSGE	DEG_Kelch_Keap1_1	0.0556
p.R145H	ACH-001610	Brain Cancer	CCLE	SGSSGE	DEG_Kelch_Keap1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35716	Transcription factor SOX-11	DEG_Kelch_Keap1_1	351:356	SGSSGE	KEAP1	0.9388	More...
Q02156	Protein kinase C epsilon type	DEG_Kelch_Keap1_1	132:137	SGSSGE	KEAP1	0.8528	More...
Q9UGU5	HMG domain-containing protein 4	DEG_Kelch_Keap1_1	153:158	SGSSGE	KEAP1	0.9956	More...
Q6NUJ5	PWWP domain-containing protein 2B	DEG_Kelch_Keap1_1	382:387	SGSSGE	KEAP1	0.9831	More...
Q9NZL6	Ral guanine nucleotide dissociation stimulator-like 1	DEG_Kelch_Keap1_1	544:549	SGSSGE	KEAP1	0.965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons