DegronMD

Uniprot ID: Q6NUJ5

Source protein: PWWP domain-containing protein 2B

Source gene: PWWP2B

Class: DEG_APCC_DBOX_1

Location: 162:170

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.904

ASA_SCORE: 92.9444

COIL: 0.7974

CONS_SCORE: 0.5134

DSS_SCORE: 0.4898

HELIX: 0.0929

FCONS_SCORE: 0.8901

RIG_SCORE: 0.7844

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R157H	TCGA-QH-A65V	LGG	TCGA	GRLILSTIR	DEG_APCC_DBOX_1	0.1944
p.R157H	DO48668	LGG	ICGC	GRLILSTIR	DEG_APCC_DBOX_1	0.1944
p.R159H	DO234199	ESAD	ICGC	GRLILSTIR	DEG_APCC_DBOX_1	0.25
p.R159H	SIDM00876	Non-Cancerous	GDSC	GRLILSTIR	DEG_APCC_DBOX_1	0.25
p.E179K	DO234334	ESAD	ICGC	GRLILSTIR	DEG_APCC_DBOX_1	0.0833
p.R157C	DO233227	GACA	ICGC	GRLILSTIR	DEG_APCC_DBOX_1	0.1944
p.T168I	DO233697	GACA	ICGC	GRLILSTIR	DEG_APCC_DBOX_1	0.7078
p.R153W	DO232224	PBCA	ICGC	GRLILSTIR	DEG_APCC_DBOX_1	0.0833
p.R172W	SIDM02059	Colorectal Carcinoma	GDSC	GRLILSTIR	DEG_APCC_DBOX_1	0.2778
p.Q175R	SIDM00487	Colorectal Carcinoma	GDSC	GRLILSTIR	DEG_APCC_DBOX_1	0.1944
p.Q175R	ACH-000963	Colon/Colorectal Cancer	CCLE	GRLILSTIR	DEG_APCC_DBOX_1	0.1944
p.I165N	SIDM01059	Melanoma	GDSC	GRLILSTIR	DEG_APCC_DBOX_1	0.6169
p.I165N	ACH-000915	Skin Cancer	CCLE	GRLILSTIR	DEG_APCC_DBOX_1	0.6169
p.R170C	SIDM01619	Endometrial Carcinoma	GDSC	GRLILSTIR	DEG_APCC_DBOX_1	0.719
p.R170C	ACH-000984	Endometrial/Uterine Cancer	CCLE	GRLILSTIR	DEG_APCC_DBOX_1	0.719
p.Q175H	ACH-000855	Esophageal Cancer	CCLE	GRLILSTIR	DEG_APCC_DBOX_1	0.1944
p.Q175H	ACH-001541	Myeloma	CCLE	GRLILSTIR	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NUJ5	PWWP domain-containing protein 2B	DEG_APCC_DBOX_1	162:170	GRLILSTIR	APC,CDC20,FZR1	0.904	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons