DegronMD - Q9ULM3(YEATS2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P476S	TCGA-05-4397	LUAD	TCGA	LPRTPTST	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.5641
p.P476S	DO25320	LUAD	ICGC	LPRTPTST	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.5641
p.S979Y	TCGA-06-5416	GBM	TCGA	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation altering degron motif	0.712
p.S979Y	DO10880	GBM	ICGC	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation altering degron motif	0.712
p.Q415H	TCGA-34-8454	LUSC	TCGA	SLERTPTK	DEG_SCF_SKP2-CKS1_1	403:410	Mutation rewiring degron network	0.1944
p.Q415H	DO50094	LUSC	ICGC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	403:410	Mutation rewiring degron network	0.1944
p.Q870L	TCGA-6A-AB49	LUSC	TCGA	LKQTPQGT	DEG_SCF_FBW7_1	854:861	Mutation rewiring degron network	0.0833
p.Q870L	DO52020	LUSC	ICGC	LKQTPQGT	DEG_SCF_FBW7_1	854:861	Mutation rewiring degron network	0.0833
p.P977L	TCGA-A5-A0G2	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation altering degron motif	0.7582
p.P977L	DO41235	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation altering degron motif	0.7582
p.P977L	SIDM00599	Osteosarcoma	GDSC	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation altering degron motif	0.7582
p.P977L	ACH-001526	Bone Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation altering degron motif	0.7582
p.P977L	HuO9	bone	COSMIC	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation altering degron motif	0.7582
p.I1025V	TCGA-AA-3811	COAD	TCGA	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation rewiring degron network	0.25
p.I1025V	DO7962	COAD	ICGC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation rewiring degron network	0.25
p.V1019M	TCGA-AJ-A3EK	UCEC	TCGA	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.7208
p.V1019M	DO41584	UCEC	ICGC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.7208
p.S1032P	TCGA-AJ-A3EL	UCEC	TCGA	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation rewiring degron network	0.0556
p.S1032P	DO41542	UCEC	ICGC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation rewiring degron network	0.0556
p.T987M	TCGA-AU-6004	COAD	TCGA	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation rewiring degron network	0.1667
p.T987M	TCGA-D5-6927	COAD	TCGA	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation rewiring degron network	0.1667
p.T987M	DO10332	COAD	ICGC	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation rewiring degron network	0.1667
p.T987M	DO7780	COAD	ICGC	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation rewiring degron network	0.1667
p.L847M	TCGA-B5-A1MX	UCEC	TCGA	LKQTPQGT	DEG_SCF_FBW7_1	854:861	Mutation rewiring degron network	0.1389
p.L847M	DO41999	UCEC	ICGC	LKQTPQGT	DEG_SCF_FBW7_1	854:861	Mutation rewiring degron network	0.1389
p.P401L	TCGA-B5-A3FA	UCEC	TCGA	SLERTPTK	DEG_SCF_SKP2-CKS1_1	403:410	Mutation rewiring degron network	0.2778
p.P401L	DO52402	UCEC	ICGC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	403:410	Mutation rewiring degron network	0.2778
p.T1115I	TCGA-BJ-A28R	THCA	TCGA	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation altering degron motif	0.8189
p.T1115I	DO39026	THCA	ICGC	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation altering degron motif	0.8189
p.A1227T	TCGA-BR-4362	STAD	TCGA	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.2222
p.A1227T	DO38336	STAD	ICGC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.2222
p.V978L	TCGA-C8-A1HM	BRCA	TCGA	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation altering degron motif	0.5654
p.V978L	DO3904	BRCA	ICGC	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation altering degron motif	0.5654
p.V978L	DO229015	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation altering degron motif	0.5654
p.K460N	TCGA-D1-A16X	UCEC	TCGA	PISTPSPS	DEG_SCF_FBW7_1	466:473	Mutation substituting flanking lysine	0.2778
p.K460N	DO41799	UCEC	ICGC	PISTPSPS	DEG_SCF_FBW7_1	466:473	Mutation substituting flanking lysine	0.2778
p.P1220S	TCGA-D3-A2J8	SKCM	TCGA	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation altering degron motif	0.6752
p.P1220S	DO37778	SKCM	ICGC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation altering degron motif	0.6752
p.P1324Q	TCGA-D3-A2JP	SKCM	TCGA	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation altering degron motif	0.5924
p.P1324Q	DO47407	SKCM	ICGC	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation altering degron motif	0.5924
p.S868L	TCGA-D3-A3MV	SKCM	TCGA	LKQTPQGT	DEG_SCF_FBW7_1	854:861	Mutation blocking phosphorylation signal	0.5833
p.S868L	DO37727	SKCM	ICGC	LKQTPQGT	DEG_SCF_FBW7_1	854:861	Mutation blocking phosphorylation signal	0.5833
p.S465F	TCGA-D3-A5GN	SKCM	TCGA	PISTPSPS	DEG_SCF_FBW7_1	466:473	Mutation blocking phosphorylation signal	0.75
p.S465F	TCGA-D3-A5GN	SKCM	TCGA	LPRTPTST	DEG_SCF_FBW7_1	475:482	Mutation blocking phosphorylation signal	0.5
p.S465F	DO47317	SKCM	ICGC	PISTPSPS	DEG_SCF_FBW7_1	466:473	Mutation blocking phosphorylation signal	0.75
p.S465F	DO47317	SKCM	ICGC	LPRTPTST	DEG_SCF_FBW7_1	475:482	Mutation blocking phosphorylation signal	0.5
p.P479S	TCGA-D3-A5GR	SKCM	TCGA	LPRTPTST	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.6752
p.P479S	DO47436	SKCM	ICGC	LPRTPTST	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.6752
p.R477Q	TCGA-D5-6540	COAD	TCGA	LPRTPTST	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.6218
p.R477Q	TCGA-G9-7525	PRAD	TCGA	LPRTPTST	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.6218
p.R477Q	DO9708	COAD	ICGC	LPRTPTST	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.6218
p.R477Q	DO36366	PRAD	ICGC	LPRTPTST	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.6218
p.L1018F	TCGA-D6-6516	HNSC	TCGA	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.587
p.L1018F	DO15623	HNSC	ICGC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.587
p.S1119G	TCGA-DI-A1BU	UCEC	TCGA	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation altering degron motif	0.6993
p.S1119G	DO42023	UCEC	ICGC	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation altering degron motif	0.6993
p.M411T	TCGA-EE-A20B	SKCM	TCGA	SLERTPTK	DEG_SCF_SKP2-CKS1_1	403:410	Mutation rewiring degron network	0.3056
p.M411T	DO37547	SKCM	ICGC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	403:410	Mutation rewiring degron network	0.3056
p.S880L	TCGA-EE-A29N	SKCM	TCGA	VSTSS	DEG_SPOP_SBC_1	888:892	Mutation rewiring degron network	0.1111
p.S880L	DO38001	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	888:892	Mutation rewiring degron network	0.1111
p.V1019A	TCGA-EV-5903	KIRP	TCGA	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6936
p.V1019A	DO20890	KIRP	ICGC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6936
p.K416N	TCGA-F5-6814	READ	TCGA	SLERTPTK	DEG_SCF_SKP2-CKS1_1	403:410	Mutation substituting flanking lysine	0.2778
p.K416N	DO36556	READ	ICGC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	403:410	Mutation substituting flanking lysine	0.2778
p.I902M	TCGA-FX-A8OO	SARC	TCGA	VSTSS	DEG_SPOP_SBC_1	888:892	Mutation rewiring degron network	0.0556
p.I902M	DO220130	SARC	ICGC	VSTSS	DEG_SPOP_SBC_1	888:892	Mutation rewiring degron network	0.0556
p.A1008T	TCGA-GM-A2D9	BRCA	TCGA	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation rewiring degron network	0.1667
p.A1008T	DO4810	BRCA	ICGC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation rewiring degron network	0.1667
p.K1108R	TCGA-NC-A5HL	LUSC	TCGA	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation substituting flanking lysine	0.3056
p.K1108R	DO219193	LUSC	ICGC	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation substituting flanking lysine	0.3056
p.E1112K	TCGA-XF-AAMZ	BLCA	TCGA	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation rewiring degron network	0.3056
p.E1112K	DO219051	BLCA	ICGC	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation rewiring degron network	0.3056
p.S1328F	TCGA-Z2-A8RT	SKCM	TCGA	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation altering degron motif	0.6871
p.S1328F	DO51301	SKCM	ICGC	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation altering degron motif	0.6871
p.V1106I	DO225070	BRCA	ICGC	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation rewiring degron network	0.1389
p.A1015T	DO228483	BRCA	ICGC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	DO229003	COCA	ICGC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	DO229346	LAML	ICGC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	DO228941	LICA	ICGC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	DO228947	LICA	ICGC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00338	Acute Myeloid Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00588	Oral Cavity Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00582	Pancreatic Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00303	Ovarian Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01020	Plasma Cell Myeloma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00586	Hepatocellular Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00437	Acute Myeloid Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00961	Ewing's Sarcoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00617	Hepatocellular Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01040	Ovarian Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00781	Colorectal Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00600	Thyroid Gland Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00602	Gastric Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01199	Hepatocellular Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00594	Acute Myeloid Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00370	T-Lymphoblastic Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00308	Chronic Myelogenous Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00231	Kidney Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00193	Colorectal Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01144	Gastric Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00057	Neuroblastoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00465	Ovarian Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00573	Glioblastoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00002	Neuroblastoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00552	Rhabdomyosarcoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00293	Small Cell Lung Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00571	Pancreatic Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00394	Cervical Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00533	Pancreatic Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00466	Ovarian Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00568	Gastric Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00301	Pancreatic Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00619	Thyroid Gland Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00687	Gastric Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00287	B-Lymphoblastic Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00556	Neuroblastoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00562	Breast Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00335	Endometrial Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00294	Small Cell Lung Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00024	Non-Cancerous	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00498	Colorectal Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00365	Small Cell Lung Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00612	Glioma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00576	Acute Myeloid Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01210	Glioblastoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00549	B-Lymphoblastic Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00618	Hepatocellular Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00989	Bladder Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00561	Other Blood Cancers	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00988	Kidney Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00616	Hepatocellular Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00954	Breast Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00380	Acute Myeloid Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00363	Acute Myeloid Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00316	Glioblastoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00243	Other Solid Cancers	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00273	Glioblastoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01439	Hepatocellular Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01372	Pancreatic Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01659	Kidney Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01612	Endometrial Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01498	Acute Myeloid Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00167	Head and Neck Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01660	Kidney Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01622	Breast Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01409	Bladder Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01611	Endometrial Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01464	Pancreatic Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01779	Gastric Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00780	Colorectal Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01432	Kidney Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01469	Pancreatic Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01445	Gastric Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01447	Glioblastoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01433	Kidney Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01454	Kidney Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01658	Unknown	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01782	Oral Cavity Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01774	Pancreatic Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM00016	Neuroblastoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01442	Glioma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01729	Endometrial Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.A1015T	SIDM01619	Endometrial Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation altering degron motif	0.6028
p.L400F	DO52743	CMDI	ICGC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	403:410	Mutation rewiring degron network	0.25
p.I853T	DO230309	COCA	ICGC	LKQTPQGT	DEG_SCF_FBW7_1	854:861	Mutation rewiring degron network	0.3056
p.V1012I	DO50332	ESAD	ICGC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation rewiring degron network	0.2778
p.V1012I	DO45037	LINC	ICGC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation rewiring degron network	0.2778
p.V1012I	SIDM00782	Colorectal Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation rewiring degron network	0.2778
p.V1012I	ACH-000381	Colon/Colorectal Cancer	CCLE	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation rewiring degron network	0.2778
p.V1012I	T84	large intestine	COSMIC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation rewiring degron network	0.2778
p.Q856R	DO234256	ESAD	ICGC	LKQTPQGT	DEG_SCF_FBW7_1	854:861	Mutation altering degron motif	0.6218
p.P396L	DO234183	ESAD	ICGC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	403:410	Mutation rewiring degron network	0.1389
p.T982M	DO234199	ESAD	ICGC	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation rewiring degron network	0.3056
p.T982M	SIDM00380	Acute Myeloid Leukemia	GDSC	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation rewiring degron network	0.3056
p.T982M	ACH-000373	Leukemia	CCLE	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation rewiring degron network	0.3056
p.T982M	SKM-1	haematopoietic and lymphoid tissue	COSMIC	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation rewiring degron network	0.3056
p.Q1123R	DO233791	GACA	ICGC	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation rewiring degron network	0.2222
p.E1329Q	DO228405	LICA	ICGC	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation altering degron motif	0.6744
p.G879V	DO228948	LICA	ICGC	VSTSS	DEG_SPOP_SBC_1	888:892	Mutation rewiring degron network	0.0833
p.V1013F	DO228952	LICA	ICGC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation rewiring degron network	0.3056
p.V1106F	DO228952	LICA	ICGC	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation rewiring degron network	0.1389
p.V1106F	DO229024	LICA	ICGC	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation rewiring degron network	0.1389
p.C1120F	DO228976	LICA	ICGC	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation rewiring degron network	0.3056
p.A491S	DO229022	LICA	ICGC	LPRTPTST	DEG_SCF_FBW7_1	475:482	Mutation rewiring degron network	0.0833
p.C1005F	DO229026	LICA	ICGC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation rewiring degron network	0.0833
p.C459F	DO229031	LICA	ICGC	PISTPSPS	DEG_SCF_FBW7_1	466:473	Mutation rewiring degron network	0.1389
p.A1107S	DO229035	LICA	ICGC	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation rewiring degron network	0.1667
p.Q845H	DO229037	LICA	ICGC	LKQTPQGT	DEG_SCF_FBW7_1	854:861	Mutation rewiring degron network	0.0833
p.V1129G	DO231031	LUSC	ICGC	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation rewiring degron network	0.0556
p.P1220L	DO220891	MELA	ICGC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation altering degron motif	0.7582
p.F1215S	DO222875	MELA	ICGC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.25
p.H485Y	DO229459	SKCA	ICGC	LPRTPTST	DEG_SCF_FBW7_1	475:482	Mutation rewiring degron network	0.25
p.L1218P	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation altering degron motif	0.6471
p.L1218P	ACH-000983	Leukemia	CCLE	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation altering degron motif	0.6471
p.L1218P	KCL-22	haematopoietic and lymphoid tissue	COSMIC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation altering degron motif	0.6471
p.F1320L	SIDM01139	Pancreatic Carcinoma	GDSC	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation rewiring degron network	0.2778
p.F1320L	PANC-02-03	pancreas	COSMIC	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation rewiring degron network	0.2778
p.A1007P	SIDM00135	Breast Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation rewiring degron network	0.1389
p.A1007P	ACH-000148	Breast Cancer	CCLE	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation rewiring degron network	0.1389
p.A1007P	Hs-578-T	breast	COSMIC	SATSLVPTP	DEG_COP1_1	1014:1022	Mutation rewiring degron network	0.1389
p.R1231H	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.1111
p.R1231H	ACH-000365	Lymphoma	CCLE	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.1111
p.R1231H	SU-DHL-4	haematopoietic and lymphoid tissue	COSMIC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.1111
p.C1232F	SIDM00411	Pancreatic Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.0833
p.C1232F	SIDM00496	Thyroid Gland Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.0833
p.C1232F	SIDM00281	Other Solid Cancers	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.0833
p.C1232F	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.0833
p.C1232F	SIDM00457	Plasma Cell Myeloma	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.0833
p.C1232F	SIDM00466	Ovarian Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.0833
p.C1232F	SIDM00619	Thyroid Gland Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.0833
p.C1232F	SIDM00687	Gastric Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.0833
p.C1232F	SIDM00556	Neuroblastoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.0833
p.C1232F	SIDM00235	Kidney Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.0833
p.C1232F	SIDM01045	Endometrial Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.0833
p.C1232F	SIDM00469	Pancreatic Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.0833
p.C1232F	SIDM00543	Melanoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.0833
p.C1232F	SIDM00996	Thyroid Gland Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.0833
p.C1232F	SIDM01735	Biliary Tract Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.0833
p.C1232F	SIDM01617	Endometrial Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.0833
p.C1232F	SIDM01320	Pancreatic Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.0833
p.C1232F	SIDM01776	Plasma Cell Myeloma	GDSC	LTPLKT	DEG_SCF_FBW7_1	1218:1223	Mutation rewiring degron network	0.0833
p.T1335I	SIDM00789	Colorectal Carcinoma	GDSC	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation rewiring degron network	0.1667
p.T1335I	ACH-000997	Colon/Colorectal Cancer	CCLE	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation rewiring degron network	0.1667
p.T1335I	ACH-001061	Colon/Colorectal Cancer	CCLE	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation rewiring degron network	0.1667
p.T1335I	HCT-15	large intestine	COSMIC	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation rewiring degron network	0.1667
p.T407A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	403:410	Mutation altering degron motif	0.825
p.T407A	ACH-002256	Leukemia	CCLE	SLERTPTK	DEG_SCF_SKP2-CKS1_1	403:410	Mutation altering degron motif	0.825
p.T407A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	403:410	Mutation altering degron motif	0.825
p.M411R	SIDM00761	Small Cell Lung Carcinoma	GDSC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	403:410	Mutation rewiring degron network	0.3056
p.M411R	ACH-000752	Lung Cancer	CCLE	SLERTPTK	DEG_SCF_SKP2-CKS1_1	403:410	Mutation rewiring degron network	0.3056
p.M411R	NCI-H196	lung	COSMIC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	403:410	Mutation rewiring degron network	0.3056
p.Q970R	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation rewiring degron network	0.1389
p.Q970R	ACH-000929	Lung Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation rewiring degron network	0.1389
p.Q970R	NCI-H2110	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation rewiring degron network	0.1389
p.P479Q	SIDM01045	Endometrial Carcinoma	GDSC	LPRTPTST	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7035
p.P479Q	ACH-000978	Endometrial/Uterine Cancer	CCLE	LPRTPTST	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7035
p.P479Q	EN	endometrium	COSMIC	LPRTPTST	DEG_SCF_FBW7_1	475:482	Mutation altering degron motif	0.7035
p.P1118L	SIDM00054	Pancreatic Carcinoma	GDSC	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation altering degron motif	0.6471
p.P1118L	SIDM00239	Kidney Carcinoma	GDSC	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation altering degron motif	0.6471
p.P1118L	ACH-000159	Kidney Cancer	CCLE	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation altering degron motif	0.6471
p.P1118L	ACH-001619	Gallbladder Cancer	CCLE	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation altering degron motif	0.6471
p.P1118L	ACH-002185	Pancreatic Cancer	CCLE	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation altering degron motif	0.6471
p.P1118L	PL18	pancreas	COSMIC	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation altering degron motif	0.6471
p.P1118L	OS-RC-2	kidney	COSMIC	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation altering degron motif	0.6471
p.E1312K	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation rewiring degron network	0.0556
p.E1312K	SIDM00574	Glioblastoma	GDSC	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation rewiring degron network	0.0556
p.E1312K	SIDM00850	Gastric Carcinoma	GDSC	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation rewiring degron network	0.0556
p.E1312K	LC-1-sq	lung	COSMIC	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation rewiring degron network	0.0556
p.E1312K	AGS	stomach	COSMIC	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation rewiring degron network	0.0556
p.E1312K	no-10	central nervous system	COSMIC	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation rewiring degron network	0.0556
p.L1121V	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation rewiring degron network	0.2778
p.L1121V	SIDM01680	Non-Cancerous	GDSC	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation rewiring degron network	0.2778
p.L1121P	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation rewiring degron network	0.2778
p.L1121P	SIDM01680	Non-Cancerous	GDSC	PETPGPS	DEG_SCF_FBW7_1	1113:1119	Mutation rewiring degron network	0.2778
p.S981C	SIDM01061	Oral Cavity Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation altering degron motif	0.7541
p.S981C	ACH-001090	Head and Neck Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation altering degron motif	0.7541
p.S981C	HN	upper aerodigestive tract	COSMIC	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation altering degron motif	0.7541
p.P483S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PISTPSPS	DEG_SCF_FBW7_1	466:473	Mutation rewiring degron network	0.0556
p.P483S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LPRTPTST	DEG_SCF_FBW7_1	475:482	Mutation rewiring degron network	0.3056
p.P483S	ACH-002222	Leukemia	CCLE	PISTPSPS	DEG_SCF_FBW7_1	466:473	Mutation rewiring degron network	0.0556
p.P483S	ACH-002222	Leukemia	CCLE	LPRTPTST	DEG_SCF_FBW7_1	475:482	Mutation rewiring degron network	0.3056
p.P483S	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PISTPSPS	DEG_SCF_FBW7_1	466:473	Mutation rewiring degron network	0.0556
p.P483S	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LPRTPTST	DEG_SCF_FBW7_1	475:482	Mutation rewiring degron network	0.3056
p.F1330C	SIDM01611	Endometrial Carcinoma	GDSC	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation rewiring degron network	0.3056
p.F1330C	ACH-000996	Endometrial/Uterine Cancer	CCLE	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation rewiring degron network	0.3056
p.P977A	SIDM01387	Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation altering degron motif	0.6392
p.P977A	ACH-000921	Lung Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation altering degron motif	0.6392
p.P968A	ACH-000829	Myeloma	CCLE	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation rewiring degron network	0.0833
p.Y1321S	ACH-000860	Lung Cancer	CCLE	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation rewiring degron network	0.3056
p.P968S	ACH-001061	Colon/Colorectal Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	977:981	Mutation rewiring degron network	0.0833
p.S1328C	ACH-001097	Lymphoma	CCLE	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation altering degron motif	0.643
p.P1323L	ACH-001573	Leukemia	CCLE	LPPTPGSE	DEG_SCF_FBW7_2	1322:1329	Mutation altering degron motif	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

YEATS2

UniProt ID: Q9ULM3

Entrez ID: 55689

Protein name: YEATS domain-containing protein 2

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for YEATS2 in