DegronMD

Uniprot ID: Q9ULM3

Source protein: YEATS domain-containing protein 2

Source gene: YEATS2

Class: DEG_SCF_FBW7_1

Location: 1113:1119

E3 ligase: FBXW7

DEGRON score: 0.7354

ASA_SCORE: 84.2286

COIL: 0.9124

CONS_SCORE: 0.3687

DSS_SCORE: 0.5917

HELIX: 0.0271

FCONS_SCORE: 1.048

RIG_SCORE: 0.6322

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1115I	TCGA-BJ-A28R	THCA	TCGA	PETPGPS	DEG_SCF_FBW7_1	0.8189
p.T1115I	DO39026	THCA	ICGC	PETPGPS	DEG_SCF_FBW7_1	0.8189
p.S1119G	TCGA-DI-A1BU	UCEC	TCGA	PETPGPS	DEG_SCF_FBW7_1	0.6993
p.S1119G	DO42023	UCEC	ICGC	PETPGPS	DEG_SCF_FBW7_1	0.6993
p.K1108R	TCGA-NC-A5HL	LUSC	TCGA	PETPGPS	DEG_SCF_FBW7_1	0.3056
p.K1108R	DO219193	LUSC	ICGC	PETPGPS	DEG_SCF_FBW7_1	0.3056
p.E1112K	TCGA-XF-AAMZ	BLCA	TCGA	PETPGPS	DEG_SCF_FBW7_1	0.3056
p.E1112K	DO219051	BLCA	ICGC	PETPGPS	DEG_SCF_FBW7_1	0.3056
p.V1106I	DO225070	BRCA	ICGC	PETPGPS	DEG_SCF_FBW7_1	0.1389
p.Q1123R	DO233791	GACA	ICGC	PETPGPS	DEG_SCF_FBW7_1	0.2222
p.V1106F	DO228952	LICA	ICGC	PETPGPS	DEG_SCF_FBW7_1	0.1389
p.V1106F	DO229024	LICA	ICGC	PETPGPS	DEG_SCF_FBW7_1	0.1389
p.C1120F	DO228976	LICA	ICGC	PETPGPS	DEG_SCF_FBW7_1	0.3056
p.A1107S	DO229035	LICA	ICGC	PETPGPS	DEG_SCF_FBW7_1	0.1667
p.V1129G	DO231031	LUSC	ICGC	PETPGPS	DEG_SCF_FBW7_1	0.0556
p.P1118L	SIDM00054	Pancreatic Carcinoma	GDSC	PETPGPS	DEG_SCF_FBW7_1	0.6471
p.P1118L	SIDM00239	Kidney Carcinoma	GDSC	PETPGPS	DEG_SCF_FBW7_1	0.6471
p.P1118L	ACH-000159	Kidney Cancer	CCLE	PETPGPS	DEG_SCF_FBW7_1	0.6471
p.P1118L	ACH-001619	Gallbladder Cancer	CCLE	PETPGPS	DEG_SCF_FBW7_1	0.6471
p.P1118L	ACH-002185	Pancreatic Cancer	CCLE	PETPGPS	DEG_SCF_FBW7_1	0.6471
p.P1118L	PL18	pancreas	COSMIC	PETPGPS	DEG_SCF_FBW7_1	0.6471
p.P1118L	OS-RC-2	kidney	COSMIC	PETPGPS	DEG_SCF_FBW7_1	0.6471
p.L1121V	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	PETPGPS	DEG_SCF_FBW7_1	0.2778
p.L1121V	SIDM01680	Non-Cancerous	GDSC	PETPGPS	DEG_SCF_FBW7_1	0.2778
p.L1121P	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	PETPGPS	DEG_SCF_FBW7_1	0.2778
p.L1121P	SIDM01680	Non-Cancerous	GDSC	PETPGPS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULM3	YEATS domain-containing protein 2	DEG_SCF_FBW7_1	1113:1119	PETPGPS	FBXW7	0.7354	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PETPGPS

Degron related mutations and impact score

Drug responses associated with YEATS2 mutations

All proteins holding degron of PETPGPS