DegronMD

Uniprot ID: Q9ULM3

Source protein: YEATS domain-containing protein 2

Source gene: YEATS2

Class: DEG_SCF_FBW7_2

Location: 1322:1329

E3 ligase: FBXW7

DEGRON score: 0.7195

ASA_SCORE: 48.35

COIL: 0.5955

CONS_SCORE: 0.4902

DSS_SCORE: 0.3652

HELIX: 0.366

FCONS_SCORE: 1.0089

RIG_SCORE: 0.708

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1324Q	TCGA-D3-A2JP	SKCM	TCGA	LPPTPGSE	DEG_SCF_FBW7_2	0.5924
p.P1324Q	DO47407	SKCM	ICGC	LPPTPGSE	DEG_SCF_FBW7_2	0.5924
p.S1328F	TCGA-Z2-A8RT	SKCM	TCGA	LPPTPGSE	DEG_SCF_FBW7_2	0.6871
p.S1328F	DO51301	SKCM	ICGC	LPPTPGSE	DEG_SCF_FBW7_2	0.6871
p.E1329Q	DO228405	LICA	ICGC	LPPTPGSE	DEG_SCF_FBW7_2	0.6744
p.F1320L	SIDM01139	Pancreatic Carcinoma	GDSC	LPPTPGSE	DEG_SCF_FBW7_2	0.2778
p.F1320L	PANC-02-03	pancreas	COSMIC	LPPTPGSE	DEG_SCF_FBW7_2	0.2778
p.T1335I	SIDM00789	Colorectal Carcinoma	GDSC	LPPTPGSE	DEG_SCF_FBW7_2	0.1667
p.T1335I	ACH-000997	Colon/Colorectal Cancer	CCLE	LPPTPGSE	DEG_SCF_FBW7_2	0.1667
p.T1335I	ACH-001061	Colon/Colorectal Cancer	CCLE	LPPTPGSE	DEG_SCF_FBW7_2	0.1667
p.T1335I	HCT-15	large_intestine	COSMIC	LPPTPGSE	DEG_SCF_FBW7_2	0.1667
p.E1312K	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	LPPTPGSE	DEG_SCF_FBW7_2	0.0556
p.E1312K	SIDM00574	Glioblastoma	GDSC	LPPTPGSE	DEG_SCF_FBW7_2	0.0556
p.E1312K	SIDM00850	Gastric Carcinoma	GDSC	LPPTPGSE	DEG_SCF_FBW7_2	0.0556
p.E1312K	LC-1-sq	lung	COSMIC	LPPTPGSE	DEG_SCF_FBW7_2	0.0556
p.E1312K	AGS	stomach	COSMIC	LPPTPGSE	DEG_SCF_FBW7_2	0.0556
p.E1312K	no-10	central_nervous_system	COSMIC	LPPTPGSE	DEG_SCF_FBW7_2	0.0556
p.F1330C	SIDM01611	Endometrial Carcinoma	GDSC	LPPTPGSE	DEG_SCF_FBW7_2	0.3056
p.F1330C	ACH-000996	Endometrial/Uterine Cancer	CCLE	LPPTPGSE	DEG_SCF_FBW7_2	0.3056
p.Y1321S	ACH-000860	Lung Cancer	CCLE	LPPTPGSE	DEG_SCF_FBW7_2	0.3056
p.S1328C	ACH-001097	Lymphoma	CCLE	LPPTPGSE	DEG_SCF_FBW7_2	0.643
p.P1323L	ACH-001573	Leukemia	CCLE	LPPTPGSE	DEG_SCF_FBW7_2	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULM3	YEATS domain-containing protein 2	DEG_SCF_FBW7_2	1322:1329	LPPTPGSE	FBXW7	0.7195	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons