DegronMD

Uniprot ID: Q9ULM3

Source protein: YEATS domain-containing protein 2

Source gene: YEATS2

Class: DEG_SCF_SKP2-CKS1_1

Location: 403:410

E3 ligase: SKP2,CSK1

DEGRON score: 0.9904

ASA_SCORE: 100.2125

COIL: 0.812

CONS_SCORE: 0.395

DSS_SCORE: 0.5155

HELIX: 0.0466

FCONS_SCORE: 1.1503

RIG_SCORE: 0.7028

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q415H	TCGA-34-8454	LUSC	TCGA	SLERTPTK	DEG_SCF_SKP2-CKS1_1	0.1944
p.Q415H	DO50094	LUSC	ICGC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P401L	TCGA-B5-A3FA	UCEC	TCGA	SLERTPTK	DEG_SCF_SKP2-CKS1_1	0.2778
p.P401L	DO52402	UCEC	ICGC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	0.2778
p.M411T	TCGA-EE-A20B	SKCM	TCGA	SLERTPTK	DEG_SCF_SKP2-CKS1_1	0.3056
p.M411T	DO37547	SKCM	ICGC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	0.3056
p.K416N	TCGA-F5-6814	READ	TCGA	SLERTPTK	DEG_SCF_SKP2-CKS1_1	0.2778
p.K416N	DO36556	READ	ICGC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	0.2778
p.L400F	DO52743	CMDI	ICGC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	0.25
p.P396L	DO234183	ESAD	ICGC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	0.1389
p.T407A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	0.825
p.T407A	ACH-002256	Leukemia	CCLE	SLERTPTK	DEG_SCF_SKP2-CKS1_1	0.825
p.T407A	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	0.825
p.M411R	SIDM00761	Small Cell Lung Carcinoma	GDSC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	0.3056
p.M411R	ACH-000752	Lung Cancer	CCLE	SLERTPTK	DEG_SCF_SKP2-CKS1_1	0.3056
p.M411R	NCI-H196	lung	COSMIC	SLERTPTK	DEG_SCF_SKP2-CKS1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULM3	YEATS domain-containing protein 2	DEG_SCF_SKP2-CKS1_1	403:410	SLERTPTK	SKP2,CSK1	0.9904	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons