DegronMD

Uniprot ID: Q9ULM3

Source protein: YEATS domain-containing protein 2

Source gene: YEATS2

Class: DEG_SCF_FBW7_1

Location: 475:482

E3 ligase: FBXW7

DEGRON score: 0.9471

ASA_SCORE: 97.25

COIL: 0.946

CONS_SCORE: 0.3787

DSS_SCORE: 0.6696

HELIX: 0.0146

FCONS_SCORE: 0.9703

RIG_SCORE: 0.5997

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P476S	TCGA-05-4397	LUAD	TCGA	LPRTPTST	DEG_SCF_FBW7_1	0.5641
p.P476S	DO25320	LUAD	ICGC	LPRTPTST	DEG_SCF_FBW7_1	0.5641
p.S465F	TCGA-D3-A5GN	SKCM	TCGA	LPRTPTST	DEG_SCF_FBW7_1	0.5
p.S465F	DO47317	SKCM	ICGC	LPRTPTST	DEG_SCF_FBW7_1	0.5
p.P479S	TCGA-D3-A5GR	SKCM	TCGA	LPRTPTST	DEG_SCF_FBW7_1	0.6752
p.P479S	DO47436	SKCM	ICGC	LPRTPTST	DEG_SCF_FBW7_1	0.6752
p.R477Q	TCGA-D5-6540	COAD	TCGA	LPRTPTST	DEG_SCF_FBW7_1	0.6218
p.R477Q	TCGA-G9-7525	PRAD	TCGA	LPRTPTST	DEG_SCF_FBW7_1	0.6218
p.R477Q	DO9708	COAD	ICGC	LPRTPTST	DEG_SCF_FBW7_1	0.6218
p.R477Q	DO36366	PRAD	ICGC	LPRTPTST	DEG_SCF_FBW7_1	0.6218
p.A491S	DO229022	LICA	ICGC	LPRTPTST	DEG_SCF_FBW7_1	0.0833
p.H485Y	DO229459	SKCA	ICGC	LPRTPTST	DEG_SCF_FBW7_1	0.25
p.P479Q	SIDM01045	Endometrial Carcinoma	GDSC	LPRTPTST	DEG_SCF_FBW7_1	0.7035
p.P479Q	ACH-000978	Endometrial/Uterine Cancer	CCLE	LPRTPTST	DEG_SCF_FBW7_1	0.7035
p.P479Q	EN	endometrium	COSMIC	LPRTPTST	DEG_SCF_FBW7_1	0.7035
p.P483S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LPRTPTST	DEG_SCF_FBW7_1	0.3056
p.P483S	ACH-002222	Leukemia	CCLE	LPRTPTST	DEG_SCF_FBW7_1	0.3056
p.P483S	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LPRTPTST	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULM3	YEATS domain-containing protein 2	DEG_SCF_FBW7_1	475:482	LPRTPTST	FBXW7	0.9471	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons