DegronMD

Uniprot ID: Q9ULM3

Source protein: YEATS domain-containing protein 2

Source gene: YEATS2

Class: DEG_SCF_FBW7_1

Location: 1218:1223

E3 ligase: FBXW7

DEGRON score: 0.7173

ASA_SCORE: 62.8667

COIL: 0.7535

CONS_SCORE: 0.4482

DSS_SCORE: 0.2662

HELIX: 0.2015

FCONS_SCORE: 0.8374

RIG_SCORE: 0.7314

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1227T	TCGA-BR-4362	STAD	TCGA	LTPLKT	DEG_SCF_FBW7_1	0.2222
p.A1227T	DO38336	STAD	ICGC	LTPLKT	DEG_SCF_FBW7_1	0.2222
p.P1220S	TCGA-D3-A2J8	SKCM	TCGA	LTPLKT	DEG_SCF_FBW7_1	0.6752
p.P1220S	DO37778	SKCM	ICGC	LTPLKT	DEG_SCF_FBW7_1	0.6752
p.P1220L	DO220891	MELA	ICGC	LTPLKT	DEG_SCF_FBW7_1	0.7582
p.F1215S	DO222875	MELA	ICGC	LTPLKT	DEG_SCF_FBW7_1	0.25
p.L1218P	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.6471
p.L1218P	ACH-000983	Leukemia	CCLE	LTPLKT	DEG_SCF_FBW7_1	0.6471
p.L1218P	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	LTPLKT	DEG_SCF_FBW7_1	0.6471
p.R1231H	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.1111
p.R1231H	ACH-000365	Lymphoma	CCLE	LTPLKT	DEG_SCF_FBW7_1	0.1111
p.R1231H	SU-DHL-4	haematopoietic_and_lymphoid_tissue	COSMIC	LTPLKT	DEG_SCF_FBW7_1	0.1111
p.C1232F	SIDM00411	Pancreatic Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.0833
p.C1232F	SIDM00496	Thyroid Gland Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.0833
p.C1232F	SIDM00281	Other Solid Cancers	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.0833
p.C1232F	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.0833
p.C1232F	SIDM00457	Plasma Cell Myeloma	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.0833
p.C1232F	SIDM00466	Ovarian Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.0833
p.C1232F	SIDM00619	Thyroid Gland Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.0833
p.C1232F	SIDM00687	Gastric Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.0833
p.C1232F	SIDM00556	Neuroblastoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.0833
p.C1232F	SIDM00235	Kidney Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.0833
p.C1232F	SIDM01045	Endometrial Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.0833
p.C1232F	SIDM00469	Pancreatic Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.0833
p.C1232F	SIDM00543	Melanoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.0833
p.C1232F	SIDM00996	Thyroid Gland Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.0833
p.C1232F	SIDM01735	Biliary Tract Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.0833
p.C1232F	SIDM01617	Endometrial Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.0833
p.C1232F	SIDM01320	Pancreatic Carcinoma	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.0833
p.C1232F	SIDM01776	Plasma Cell Myeloma	GDSC	LTPLKT	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPLKT

Degron related mutations and impact score

Drug responses associated with YEATS2 mutations

All proteins holding degron of LTPLKT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULM3	YEATS domain-containing protein 2	DEG_SCF_FBW7_1	1218:1223	LTPLKT	FBXW7	0.7173	More...