DegronMD

Uniprot ID: Q9ULM3

Source protein: YEATS domain-containing protein 2

Source gene: YEATS2

Class: DEG_SCF_FBW7_1

Location: 466:473

E3 ligase: FBXW7

DEGRON score: 0.9972

ASA_SCORE: 87.6375

COIL: 0.9629

CONS_SCORE: 0.4096

DSS_SCORE: 0.6347

HELIX: 0.0078

FCONS_SCORE: 0.9959

RIG_SCORE: 0.5713

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K460N	TCGA-D1-A16X	UCEC	TCGA	PISTPSPS	DEG_SCF_FBW7_1	0.2778
p.K460N	DO41799	UCEC	ICGC	PISTPSPS	DEG_SCF_FBW7_1	0.2778
p.S465F	TCGA-D3-A5GN	SKCM	TCGA	PISTPSPS	DEG_SCF_FBW7_1	0.75
p.S465F	DO47317	SKCM	ICGC	PISTPSPS	DEG_SCF_FBW7_1	0.75
p.C459F	DO229031	LICA	ICGC	PISTPSPS	DEG_SCF_FBW7_1	0.1389
p.P483S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PISTPSPS	DEG_SCF_FBW7_1	0.0556
p.P483S	ACH-002222	Leukemia	CCLE	PISTPSPS	DEG_SCF_FBW7_1	0.0556
p.P483S	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PISTPSPS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULM3	YEATS domain-containing protein 2	DEG_SCF_FBW7_1	466:473	PISTPSPS	FBXW7	0.9972	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons