DegronMD

Uniprot ID: Q9ULM3

Source protein: YEATS domain-containing protein 2

Source gene: YEATS2

Class: DEG_COP1_1

Location: 1014:1022

E3 ligase: COP1

DEGRON score: 0.9313

ASA_SCORE: 83.2667

COIL: 0.8967

CONS_SCORE: 0.3347

DSS_SCORE: 0.3718

HELIX: 0.019

FCONS_SCORE: 0.9452

RIG_SCORE: 0.7608

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1025V	TCGA-AA-3811	COAD	TCGA	SATSLVPTP	DEG_COP1_1	0.25
p.I1025V	DO7962	COAD	ICGC	SATSLVPTP	DEG_COP1_1	0.25
p.V1019M	TCGA-AJ-A3EK	UCEC	TCGA	SATSLVPTP	DEG_COP1_1	0.7208
p.V1019M	DO41584	UCEC	ICGC	SATSLVPTP	DEG_COP1_1	0.7208
p.S1032P	TCGA-AJ-A3EL	UCEC	TCGA	SATSLVPTP	DEG_COP1_1	0.0556
p.S1032P	DO41542	UCEC	ICGC	SATSLVPTP	DEG_COP1_1	0.0556
p.L1018F	TCGA-D6-6516	HNSC	TCGA	SATSLVPTP	DEG_COP1_1	0.587
p.L1018F	DO15623	HNSC	ICGC	SATSLVPTP	DEG_COP1_1	0.587
p.V1019A	TCGA-EV-5903	KIRP	TCGA	SATSLVPTP	DEG_COP1_1	0.6936
p.V1019A	DO20890	KIRP	ICGC	SATSLVPTP	DEG_COP1_1	0.6936
p.A1008T	TCGA-GM-A2D9	BRCA	TCGA	SATSLVPTP	DEG_COP1_1	0.1667
p.A1008T	DO4810	BRCA	ICGC	SATSLVPTP	DEG_COP1_1	0.1667
p.A1015T	DO228483	BRCA	ICGC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	DO229003	COCA	ICGC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	DO229346	LAML	ICGC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	DO228941	LICA	ICGC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	DO228947	LICA	ICGC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00338	Acute Myeloid Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00588	Oral Cavity Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00582	Pancreatic Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00303	Ovarian Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01020	Plasma Cell Myeloma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00586	Hepatocellular Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00437	Acute Myeloid Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00961	Ewing's Sarcoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00617	Hepatocellular Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01040	Ovarian Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00781	Colorectal Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00600	Thyroid Gland Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00602	Gastric Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01199	Hepatocellular Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00594	Acute Myeloid Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00370	T-Lymphoblastic Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00308	Chronic Myelogenous Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00231	Kidney Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00193	Colorectal Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01144	Gastric Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00057	Neuroblastoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00465	Ovarian Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00573	Glioblastoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00002	Neuroblastoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00552	Rhabdomyosarcoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00293	Small Cell Lung Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00571	Pancreatic Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00394	Cervical Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00533	Pancreatic Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00466	Ovarian Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00568	Gastric Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00301	Pancreatic Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00619	Thyroid Gland Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00687	Gastric Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00287	B-Lymphoblastic Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00556	Neuroblastoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00562	Breast Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00335	Endometrial Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00294	Small Cell Lung Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00024	Non-Cancerous	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00498	Colorectal Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00365	Small Cell Lung Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00612	Glioma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00576	Acute Myeloid Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01210	Glioblastoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00549	B-Lymphoblastic Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00618	Hepatocellular Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00989	Bladder Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00561	Other Blood Cancers	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00988	Kidney Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00616	Hepatocellular Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00954	Breast Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00380	Acute Myeloid Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00363	Acute Myeloid Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00316	Glioblastoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00243	Other Solid Cancers	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00273	Glioblastoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01439	Hepatocellular Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01372	Pancreatic Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01659	Kidney Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01612	Endometrial Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01498	Acute Myeloid Leukemia	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00167	Head and Neck Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01660	Kidney Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01622	Breast Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01409	Bladder Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01611	Endometrial Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01464	Pancreatic Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01779	Gastric Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00780	Colorectal Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01432	Kidney Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01469	Pancreatic Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01445	Gastric Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01447	Glioblastoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01433	Kidney Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01454	Kidney Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01658	Unknown	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01782	Oral Cavity Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01774	Pancreatic Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM00016	Neuroblastoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01442	Glioma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01729	Endometrial Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.A1015T	SIDM01619	Endometrial Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.6028
p.V1012I	DO50332	ESAD	ICGC	SATSLVPTP	DEG_COP1_1	0.2778
p.V1012I	DO45037	LINC	ICGC	SATSLVPTP	DEG_COP1_1	0.2778
p.V1012I	SIDM00782	Colorectal Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.2778
p.V1012I	ACH-000381	Colon/Colorectal Cancer	CCLE	SATSLVPTP	DEG_COP1_1	0.2778
p.V1012I	T84	large_intestine	COSMIC	SATSLVPTP	DEG_COP1_1	0.2778
p.V1013F	DO228952	LICA	ICGC	SATSLVPTP	DEG_COP1_1	0.3056
p.C1005F	DO229026	LICA	ICGC	SATSLVPTP	DEG_COP1_1	0.0833
p.A1007P	SIDM00135	Breast Carcinoma	GDSC	SATSLVPTP	DEG_COP1_1	0.1389
p.A1007P	ACH-000148	Breast Cancer	CCLE	SATSLVPTP	DEG_COP1_1	0.1389
p.A1007P	Hs-578-T	breast	COSMIC	SATSLVPTP	DEG_COP1_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SATSLVPTP

Degron related mutations and impact score

Drug responses associated with YEATS2 mutations

All proteins holding degron of SATSLVPTP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULM3	YEATS domain-containing protein 2	DEG_COP1_1	1014:1022	SATSLVPTP	COP1	0.9313	More...