DegronMD

Uniprot ID: Q9ULM3

Source protein: YEATS domain-containing protein 2

Source gene: YEATS2

Class: DEG_SCF_FBW7_1

Location: 854:861

E3 ligase: FBXW7

DEGRON score: 0.8991

ASA_SCORE: 86.75

COIL: 0.7703

CONS_SCORE: 0.3741

DSS_SCORE: 0.3951

HELIX: 0.0305

FCONS_SCORE: 1.0101

RIG_SCORE: 0.7775

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q870L	TCGA-6A-AB49	LUSC	TCGA	LKQTPQGT	DEG_SCF_FBW7_1	0.0833
p.Q870L	DO52020	LUSC	ICGC	LKQTPQGT	DEG_SCF_FBW7_1	0.0833
p.L847M	TCGA-B5-A1MX	UCEC	TCGA	LKQTPQGT	DEG_SCF_FBW7_1	0.1389
p.L847M	DO41999	UCEC	ICGC	LKQTPQGT	DEG_SCF_FBW7_1	0.1389
p.S868L	TCGA-D3-A3MV	SKCM	TCGA	LKQTPQGT	DEG_SCF_FBW7_1	0.5833
p.S868L	DO37727	SKCM	ICGC	LKQTPQGT	DEG_SCF_FBW7_1	0.5833
p.I853T	DO230309	COCA	ICGC	LKQTPQGT	DEG_SCF_FBW7_1	0.3056
p.Q856R	DO234256	ESAD	ICGC	LKQTPQGT	DEG_SCF_FBW7_1	0.6218
p.Q845H	DO229037	LICA	ICGC	LKQTPQGT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULM3	YEATS domain-containing protein 2	DEG_SCF_FBW7_1	854:861	LKQTPQGT	FBXW7	0.8991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons