DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VSTSS
Uniprot ID:
Q68DE3
Source protein:
Basic helix-loop-helix domain-containing protein USF3
Source gene:
USF3
Class:
DEG_SPOP_SBC_1
Location:
776:780
E3 ligase:
SPOP
DEGRON score:
0.6894
ASA_SCORE:
85.14
COIL:
0.9256
CONS_SCORE:
0.4186
DSS_SCORE:
0.2635
HELIX:
0.0362
FCONS_SCORE:
0.9201
RIG_SCORE:
0.7639
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with USF3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VSTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P35716
Transcription factor SOX-11
DEG_SPOP_SBC_1
339:343
VSTSS
SPOP
0.9784
More...
P42684
Tyrosine-protein kinase ABL2
DEG_SPOP_SBC_1
816:820
VSTSS
SPOP
0.9961
More...
P54259
Atrophin-1
DEG_SPOP_SBC_1
38:42
VSTSS
SPOP
0.9947
More...
P57768
Sorting nexin-16
DEG_SPOP_SBC_1
33:37
VSTSS
SPOP
0.9979
More...
Q14149
MORC family CW-type zinc finger protein 3
DEG_SPOP_SBC_1
872:876
VSTSS
SPOP
0.9439
More...
Q68DE3
Basic helix-loop-helix domain-containing protein USF3
DEG_SPOP_SBC_1
776:780
VSTSS
SPOP
0.6894
More...
Q6PJT7
Zinc finger CCCH domain-containing protein 14
DEG_SPOP_SBC_1
131:135
VSTSS
SPOP
0.9971
More...
Q76L83
Putative Polycomb group protein ASXL2
DEG_SPOP_SBC_1
1333:1337
VSTSS
SPOP
0.961
More...
Q7L1W4
Volume-regulated anion channel subunit LRRC8D
DEG_SPOP_SBC_1
238:242
VSTSS
SPOP
0.6957
More...
Q86UE8
Serine/threonine-protein kinase tousled-like 2
DEG_SPOP_SBC_1
749:753
VSTSS
SPOP
0.9974
More...
Q8N3K9
Cardiomyopathy-associated protein 5
DEG_SPOP_SBC_1
1839:1843
VSTSS
SPOP
0.9049
More...
Q8NFU7
Methylcytosine dioxygenase TET1
DEG_SPOP_SBC_1
569:573
VSTSS
SPOP
0.9917
More...
Q8TF72
Protein Shroom3
DEG_SPOP_SBC_1
815:819
VSTSS
SPOP
0.9994
More...
Q9NZM3
Intersectin-2
DEG_SPOP_SBC_1
162:166
VSTSS
SPOP
0.9894
More...
Q9ULM3
YEATS domain-containing protein 2
DEG_SPOP_SBC_1
888:892
VSTSS
SPOP
0.9942
More...
Q9Y4D8
Probable E3 ubiquitin-protein ligase HECTD4
DEG_SPOP_SBC_1
3049:3053
VSTSS
SPOP
0.9533
More...
Q9BQE6
LBH domain-containing protein 1
DEG_SPOP_SBC_1
51:55
VSTSS
SPOP
0.5933
More...