DegronMD - P54259(ATN1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R935L	TCGA-09-2044	OV	TCGA	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.1389
p.R935L	DO28923	OV	ICGC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.1389
p.L352V	TCGA-18-3406	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.L352V	DO26438	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.G681D	TCGA-2W-A8YY	CESC	TCGA	PPGY	ITCH	670:673	Mutation rewiring degron network	0.1111
p.G681D	DO223732	CESC	ICGC	PPGY	ITCH	670:673	Mutation rewiring degron network	0.1111
p.S571F	TCGA-4Z-AA84	BLCA	TCGA	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation altering degron motif	0.7982
p.S571F	DO218988	BLCA	ICGC	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation altering degron motif	0.7982
p.A652V	TCGA-77-8156	LUSC	TCGA	PPGY	ITCH	654:657	Mutation rewiring degron network	0.2778
p.A652V	DO26802	LUSC	ICGC	PPGY	ITCH	654:657	Mutation rewiring degron network	0.2778
p.R935Q	TCGA-85-8048	LUSC	TCGA	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.1389
p.R935Q	DO27389	LUSC	ICGC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.1389
p.T630M	TCGA-A5-A2K3	UCEC	TCGA	PPPY	ITCH	636:639	Mutation rewiring degron network	0.1667
p.T630M	DO43899	UCEC	ICGC	PPPY	ITCH	636:639	Mutation rewiring degron network	0.1667
p.A648V	TCGA-AG-A01J	READ	TCGA	PPPY	ITCH	636:639	Mutation rewiring degron network	0.0833
p.A648V	TCGA-AG-A01J	READ	TCGA	PPGY	ITCH	654:657	Mutation rewiring degron network	0.1667
p.A648V	DO36385	READ	ICGC	PPPY	ITCH	636:639	Mutation rewiring degron network	0.0833
p.A648V	DO36385	READ	ICGC	PPGY	ITCH	654:657	Mutation rewiring degron network	0.1667
p.A648V	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	636:639	Mutation rewiring degron network	0.0833
p.A648V	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PPGY	ITCH	654:657	Mutation rewiring degron network	0.1667
p.A648V	ACH-002222	Leukemia	CCLE	PPPY	ITCH	636:639	Mutation rewiring degron network	0.0833
p.A648V	ACH-002222	Leukemia	CCLE	PPGY	ITCH	654:657	Mutation rewiring degron network	0.1667
p.A648V	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	636:639	Mutation rewiring degron network	0.0833
p.A648V	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	654:657	Mutation rewiring degron network	0.1667
p.A597V	TCGA-AJ-A3BH	UCEC	TCGA	VTTSS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0556
p.A597V	DO41638	UCEC	ICGC	VTTSS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0556
p.T351P	TCGA-AP-A051	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0556
p.T351P	DO42673	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0556
p.G656E	TCGA-AX-A06F	UCEC	TCGA	PPGY	ITCH	654:657	Mutation altering degron motif	0.6087
p.G656E	DO41752	UCEC	ICGC	PPGY	ITCH	654:657	Mutation altering degron motif	0.6087
p.A368V	TCGA-AZ-6601	COAD	TCGA	PASSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.25
p.A368V	TCGA-AZ-6601	COAD	TCGA	PYSSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.1667
p.A368V	DO8119	COAD	ICGC	PASSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.25
p.A368V	DO8119	COAD	ICGC	PYSSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.1667
p.A368V	DO233115	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.25
p.A368V	DO233115	GACA	ICGC	PYSSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.1667
p.P603L	TCGA-B5-A11E	UCEC	TCGA	VTTSS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.2222
p.P603L	DO222604	ESCA	ICGC	VTTSS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.2222
p.P603L	DO41644	UCEC	ICGC	VTTSS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.2222
p.S376L	TCGA-BA-5558	HNSC	TCGA	PYSSS	DEG_SPOP_SBC_1	374:378	Mutation altering degron motif	0.7667
p.S376L	DO15783	HNSC	ICGC	PYSSS	DEG_SPOP_SBC_1	374:378	Mutation altering degron motif	0.7667
p.P446H	TCGA-BQ-5876	KIRP	TCGA	PPPY	ITCH	445:448	Mutation altering degron motif	0.7694
p.P446H	DO20759	KIRP	ICGC	PPPY	ITCH	445:448	Mutation altering degron motif	0.7694
p.P445S	TCGA-BR-8372	STAD	TCGA	PPPY	ITCH	445:448	Mutation altering degron motif	0.6752
p.P445S	DO47873	STAD	ICGC	PPPY	ITCH	445:448	Mutation altering degron motif	0.6752
p.S393C	TCGA-C4-A0F1	BLCA	TCGA	AASSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1944
p.S393C	DO581	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1944
p.S571Y	TCGA-CV-5977	HNSC	TCGA	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation altering degron motif	0.712
p.S571Y	DO14403	HNSC	ICGC	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation altering degron motif	0.712
p.G660R	TCGA-CV-A45Q	HNSC	TCGA	PPGY	ITCH	654:657	Mutation rewiring degron network	0.25
p.G660R	TCGA-CV-A45Q	HNSC	TCGA	PPGY	ITCH	670:673	Mutation rewiring degron network	0.0556
p.G660R	DO228732	GACA	ICGC	PPGY	ITCH	654:657	Mutation rewiring degron network	0.25
p.G660R	DO228732	GACA	ICGC	PPGY	ITCH	670:673	Mutation rewiring degron network	0.0556
p.G660R	DO49060	HNSC	ICGC	PPGY	ITCH	654:657	Mutation rewiring degron network	0.25
p.G660R	DO49060	HNSC	ICGC	PPGY	ITCH	670:673	Mutation rewiring degron network	0.0556
p.G640R	TCGA-D1-A2G0	UCEC	TCGA	PPPY	ITCH	636:639	Mutation rewiring degron network	0.3056
p.G640R	DO43049	UCEC	ICGC	PPPY	ITCH	636:639	Mutation rewiring degron network	0.3056
p.G562S	TCGA-DA-A1I0	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.1944
p.G562S	DO37719	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.1944
p.P566L	TCGA-DH-5140	LGG	TCGA	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.3056
p.P566L	DO22701	LGG	ICGC	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.3056
p.S394P	TCGA-DI-A1BU	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1667
p.S394P	DO42023	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1667
p.G656A	TCGA-E5-A4U1	BLCA	TCGA	PPGY	ITCH	654:657	Mutation altering degron motif	0.6429
p.G656A	DO44061	BLCA	ICGC	PPGY	ITCH	654:657	Mutation altering degron motif	0.6429
p.V911L	TCGA-EA-A410	CESC	TCGA	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.1111
p.V911L	DO49929	CESC	ICGC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.1111
p.Q580E	TCGA-EW-A1J5	BRCA	TCGA	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0833
p.Q580E	DO6144	BRCA	ICGC	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.0833
p.P566S	TCGA-EY-A1GT	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.3056
p.P566S	DO40936	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.3056
p.D927Y	TCGA-F7-7848	HNSC	TCGA	NVPALYSSDP	CBL_PTK	919:928	Mutation altering degron motif	0.6214
p.D927Y	DO14198	HNSC	ICGC	NVPALYSSDP	CBL_PTK	919:928	Mutation altering degron motif	0.6214
p.Y649C	TCGA-FD-A6TG	BLCA	TCGA	PPPY	ITCH	636:639	Mutation blocking phosphorylation signal	0.5
p.Y649C	TCGA-FD-A6TG	BLCA	TCGA	PPGY	ITCH	654:657	Mutation blocking phosphorylation signal	0.6389
p.Y649C	DO49760	BLCA	ICGC	PPPY	ITCH	636:639	Mutation blocking phosphorylation signal	0.5
p.Y649C	DO49760	BLCA	ICGC	PPGY	ITCH	654:657	Mutation blocking phosphorylation signal	0.6389
p.P644L	TCGA-FR-A3YN	SKCM	TCGA	PPPY	ITCH	636:639	Mutation rewiring degron network	0.1944
p.P644L	TCGA-FR-A3YN	SKCM	TCGA	PPGY	ITCH	654:657	Mutation rewiring degron network	0.0556
p.P644L	DO38111	SKCM	ICGC	PPPY	ITCH	636:639	Mutation rewiring degron network	0.1944
p.P644L	DO38111	SKCM	ICGC	PPGY	ITCH	654:657	Mutation rewiring degron network	0.0556
p.S559I	TCGA-IB-7651	PAAD	TCGA	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.1111
p.S559I	DO46657	PAAD	ICGC	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.1111
p.Q429E	TCGA-MF-A522	LUSC	TCGA	PPKY	ITCH	424:427	Mutation rewiring degron network	0.2778
p.Q429E	DO45526	LUSC	ICGC	PPKY	ITCH	424:427	Mutation rewiring degron network	0.2778
p.S661A	TCGA-NC-A5HJ	LUSC	TCGA	PPGY	ITCH	654:657	Mutation blocking phosphorylation signal	0.6667
p.S661A	TCGA-NC-A5HJ	LUSC	TCGA	PPGY	ITCH	670:673	Mutation blocking phosphorylation signal	0.5278
p.S661A	DO219189	LUSC	ICGC	PPGY	ITCH	654:657	Mutation blocking phosphorylation signal	0.6667
p.S661A	DO219189	LUSC	ICGC	PPGY	ITCH	670:673	Mutation blocking phosphorylation signal	0.5278
p.P414S	TCGA-Q1-A73O	CESC	TCGA	PPKY	ITCH	424:427	Mutation rewiring degron network	0.0556
p.P414S	DO51612	CESC	ICGC	PPKY	ITCH	424:427	Mutation rewiring degron network	0.0556
p.S632F	TCGA-QK-A6V9	HNSC	TCGA	PPPY	ITCH	636:639	Mutation blocking phosphorylation signal	0.6667
p.S632F	DO52095	HNSC	ICGC	PPPY	ITCH	636:639	Mutation blocking phosphorylation signal	0.6667
p.R674G	TCGA-QK-A6V9	HNSC	TCGA	PPGY	ITCH	670:673	Mutation rewiring degron network	0.3056
p.R674G	DO52095	HNSC	ICGC	PPGY	ITCH	670:673	Mutation rewiring degron network	0.3056
p.S395C	TCGA-XF-A9SI	BLCA	TCGA	AASSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1389
p.S395C	DO51914	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1389
p.S382C	DO48378	BLCA	ICGC	PYSSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.2222
p.S382C	DO48378	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.2778
p.P35T	DO48408	BLCA	ICGC	VSTSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.25
p.A631T	DO227987	COCA	ICGC	PPPY	ITCH	636:639	Mutation rewiring degron network	0.1944
p.A910T	DO233088	GACA	ICGC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.0833
p.S677L	DO233779	GACA	ICGC	PPGY	ITCH	670:673	Mutation blocking phosphorylation signal	0.6667
p.S395F	DO233732	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1389
p.A652T	DO233882	GACA	ICGC	PPGY	ITCH	654:657	Mutation rewiring degron network	0.2778
p.G660W	DO229018	LICA	ICGC	PPGY	ITCH	654:657	Mutation rewiring degron network	0.25
p.G660W	DO229018	LICA	ICGC	PPGY	ITCH	670:673	Mutation rewiring degron network	0.0556
p.P360L	DO229050	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.3056
p.G562V	DO229006	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.1944
p.Y599H	DO231704	LINC	ICGC	VTTSS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1111
p.S386L	DO222731	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	384:388	Mutation altering degron motif	0.7667
p.D912G	DO34016	PACA	ICGC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.1389
p.P433T	DO232224	PBCA	ICGC	PPKY	ITCH	424:427	Mutation rewiring degron network	0.1667
p.T609I	DO232224	PBCA	ICGC	VTTSS	DEG_SPOP_SBC_1	607:611	Mutation altering degron motif	0.7078
p.P671L	DO229542	UTCA	ICGC	PPGY	ITCH	670:673	Mutation altering degron motif	0.7582
p.A47D	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VSTSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1944
p.A47D	ACH-000995	Leukemia	CCLE	VSTSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1944
p.A47D	Jurkat	haematopoietic and lymphoid tissue	COSMIC	VSTSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1944
p.P398L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.0556
p.P398L	ACH-000983	Leukemia	CCLE	AASSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.0556
p.P398L	KCL-22	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.0556
p.V607I	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VTTSS	DEG_SPOP_SBC_1	607:611	Mutation altering degron motif	0.7076
p.V607I	ACH-000789	Lung Cancer	CCLE	VTTSS	DEG_SPOP_SBC_1	607:611	Mutation altering degron motif	0.7076
p.V607I	NCI-H810	lung	COSMIC	VTTSS	DEG_SPOP_SBC_1	607:611	Mutation altering degron motif	0.7076
p.S572Y	SIDM00614	Hepatocellular Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.3056
p.K49T	SIDM00377	Other Sarcomas	GDSC	VSTSS	DEG_SPOP_SBC_1	38:42	Mutation substituting flanking lysine	0.25
p.K49T	ACH-001655	Endometrial/Uterine Cancer	CCLE	VSTSS	DEG_SPOP_SBC_1	38:42	Mutation substituting flanking lysine	0.25
p.K49T	SKN	soft tissue	COSMIC	VSTSS	DEG_SPOP_SBC_1	38:42	Mutation substituting flanking lysine	0.25
p.V911M	SIDM00377	Other Sarcomas	GDSC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.1111
p.V911M	ACH-001655	Endometrial/Uterine Cancer	CCLE	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.1111
p.V911M	SKN	soft tissue	COSMIC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.1111
p.P633S	SIDM00392	Melanoma	GDSC	PPPY	ITCH	636:639	Mutation rewiring degron network	0.25
p.P633S	SIDM01442	Glioma	GDSC	PPPY	ITCH	636:639	Mutation rewiring degron network	0.25
p.P633S	ACH-000807	Brain Cancer	CCLE	PPPY	ITCH	636:639	Mutation rewiring degron network	0.25
p.P633S	ACH-000810	Skin Cancer	CCLE	PPPY	ITCH	636:639	Mutation rewiring degron network	0.25
p.P633S	SK-MEL-30	skin	COSMIC	PPPY	ITCH	636:639	Mutation rewiring degron network	0.25
p.G565D	SIDM00680	Colorectal Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.2778
p.G565D	ACH-000957	Colon/Colorectal Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.2778
p.G565D	LS-180	large intestine	COSMIC	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.2778
p.R938H	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.0556
p.R938H	ACH-002263	Esophageal Cancer	CCLE	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.0556
p.R938H	KYSE-220	oesophagus	COSMIC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.0556
p.A930G	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.2778
p.A930G	SIDM00230	Small Cell Lung Carcinoma	GDSC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.2778
p.A930G	ACH-000718	Lung Cancer	CCLE	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.2778
p.A930G	IST-SL2	lung	COSMIC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.2778
p.A930G	NCI-H2291	lung	COSMIC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.2778
p.S571C	SIDM00506	Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation altering degron motif	0.7541
p.S571C	ACH-000508	Lung Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation altering degron motif	0.7541
p.S571C	COR-L88	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation altering degron motif	0.7541
p.P398A	SIDM00950	Pancreatic Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.0556
p.P398A	ACH-000243	Pancreatic Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.0556
p.P398A	DAN-G	pancreas	COSMIC	AASSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.0556
p.A929T	SIDM00277	Acute Myeloid Leukemia	GDSC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.3056
p.A929T	SIDM00520	Mesothelioma	GDSC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.3056
p.A929T	SIDM01100	Neuroblastoma	GDSC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.3056
p.A929T	SIDM00638	Cervical Carcinoma	GDSC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.3056
p.A929T	SIDM01768	Melanoma	GDSC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.3056
p.E932V	SIDM00874	Breast Carcinoma	GDSC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.2222
p.E932V	HCC1937	breast	COSMIC	NVPALYSSDP	CBL_PTK	919:928	Mutation rewiring degron network	0.2222
p.P430H	SIDM00596	Endometrial Carcinoma	GDSC	PPKY	ITCH	424:427	Mutation rewiring degron network	0.25
p.P430H	ACH-000941	Endometrial/Uterine Cancer	CCLE	PPKY	ITCH	424:427	Mutation rewiring degron network	0.25
p.P430H	ACH-000954	Endometrial/Uterine Cancer	CCLE	PPKY	ITCH	424:427	Mutation rewiring degron network	0.25
p.P430H	ACH-001517	Endometrial/Uterine Cancer	CCLE	PPKY	ITCH	424:427	Mutation rewiring degron network	0.25
p.P430H	HEC-1	endometrium	COSMIC	PPKY	ITCH	424:427	Mutation rewiring degron network	0.25
p.P563H	SIDM00014	Colorectal Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.2222
p.P563H	LIM1215	large intestine	COSMIC	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.2222
p.S29L	SIDM00941	Kidney Carcinoma	GDSC	VSTSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.0833
p.S29L	CAKI-1	kidney	COSMIC	VSTSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.0833
p.S559N	SIDM00487	Colorectal Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.1111
p.S559N	ACH-000963	Colon/Colorectal Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.1111
p.S559N	CCK-81	large intestine	COSMIC	PVSSS	DEG_SPOP_SBC_1	567:571	Mutation rewiring degron network	0.1111
p.S50Y	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VSTSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1111
p.S50Y	ACH-000920	Leukemia	CCLE	VSTSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1111
p.S50Y	CML-T1	haematopoietic and lymphoid tissue	COSMIC	VSTSS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1111
p.R450H	SIDM00968	Ovarian Carcinoma	GDSC	PPPY	ITCH	445:448	Mutation rewiring degron network	0.2778
p.R450H	SIDM00163	Biliary Tract Carcinoma	GDSC	PPPY	ITCH	445:448	Mutation rewiring degron network	0.2778
p.R450H	SIDM01215	Ovarian Carcinoma	GDSC	PPPY	ITCH	445:448	Mutation rewiring degron network	0.2778
p.T428A	SIDM00537	Colorectal Carcinoma	GDSC	PPKY	ITCH	424:427	Mutation rewiring degron network	0.3056
p.T428A	ACH-001345	Colon/Colorectal Cancer	CCLE	PPKY	ITCH	424:427	Mutation rewiring degron network	0.3056
p.T428A	GP5d	large intestine	COSMIC	PPKY	ITCH	424:427	Mutation rewiring degron network	0.3056
p.A643D	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	636:639	Mutation rewiring degron network	0.2222
p.A643D	ACH-001127	Leukemia	CCLE	PPPY	ITCH	636:639	Mutation rewiring degron network	0.2222
p.A643D	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PPPY	ITCH	636:639	Mutation rewiring degron network	0.2222
p.L418I	SIDM01609	Endometrial Carcinoma	GDSC	PPKY	ITCH	424:427	Mutation rewiring degron network	0.1667
p.L418I	ACH-000972	Endometrial/Uterine Cancer	CCLE	PPKY	ITCH	424:427	Mutation rewiring degron network	0.1667
p.P644Q	SIDM01694	B-Lymphoblastic Leukemia	GDSC	PPPY	ITCH	636:639	Mutation rewiring degron network	0.1944
p.P644Q	SIDM01694	B-Lymphoblastic Leukemia	GDSC	PPGY	ITCH	654:657	Mutation rewiring degron network	0.0556
p.P644Q	ACH-000728	Leukemia	CCLE	PPPY	ITCH	636:639	Mutation rewiring degron network	0.1944
p.P644Q	ACH-000728	Leukemia	CCLE	PPGY	ITCH	654:657	Mutation rewiring degron network	0.0556
p.P633Q	SIDM01442	Glioma	GDSC	PPPY	ITCH	636:639	Mutation rewiring degron network	0.25
p.P633Q	ACH-000807	Brain Cancer	CCLE	PPPY	ITCH	636:639	Mutation rewiring degron network	0.25
p.S925N	ACH-000966	Ovarian Cancer	CCLE	NVPALYSSDP	CBL_PTK	919:928	Mutation altering degron motif	0.7069
p.P682T	ACH-000983	Leukemia	CCLE	PPGY	ITCH	670:673	Mutation rewiring degron network	0.0833
p.S380G	ACH-001484	Leukemia	CCLE	PYSSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.2778
p.S380G	ACH-001484	Leukemia	CCLE	AASSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.2222
p.S380G	ACH-001485	Leukemia	CCLE	PYSSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.2778
p.S380G	ACH-001485	Leukemia	CCLE	AASSS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.2222
p.R450G	ACH-001690	Head and Neck Cancer	CCLE	PPPY	ITCH	445:448	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATN1

UniProt ID: P54259

Entrez ID: 1822

Protein name: Atrophin-1 (Dentatorubral-pallidoluysian atrophy protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATN1 in