DegronMD

Uniprot ID: P54259

Source protein: Atrophin-1

Source gene: ATN1

Class: DEG_SPOP_SBC_1

Location: 607:611

E3 ligase: SPOP

DEGRON score: 0.9514

ASA_SCORE: 85.76

COIL: 0.9388

CONS_SCORE: 0.6049

DSS_SCORE: 0.4155

HELIX: 0.042

FCONS_SCORE: 0.9133

RIG_SCORE: 0.7274

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A597V	TCGA-AJ-A3BH	UCEC	TCGA	VTTSS	DEG_SPOP_SBC_1	0.0556
p.A597V	DO41638	UCEC	ICGC	VTTSS	DEG_SPOP_SBC_1	0.0556
p.P603L	TCGA-B5-A11E	UCEC	TCGA	VTTSS	DEG_SPOP_SBC_1	0.2222
p.P603L	DO222604	ESCA	ICGC	VTTSS	DEG_SPOP_SBC_1	0.2222
p.P603L	DO41644	UCEC	ICGC	VTTSS	DEG_SPOP_SBC_1	0.2222
p.Y599H	DO231704	LINC	ICGC	VTTSS	DEG_SPOP_SBC_1	0.1111
p.T609I	DO232224	PBCA	ICGC	VTTSS	DEG_SPOP_SBC_1	0.7078
p.V607I	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	VTTSS	DEG_SPOP_SBC_1	0.7076
p.V607I	ACH-000789	Lung Cancer	CCLE	VTTSS	DEG_SPOP_SBC_1	0.7076
p.V607I	NCI-H810	lung	COSMIC	VTTSS	DEG_SPOP_SBC_1	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22105	Tenascin-X	DEG_SPOP_SBC_1	3666:3670	VTTSS	SPOP	0.8858	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	607:611	VTTSS	SPOP	0.9514	More...
Q14119	Vascular endothelial zinc finger 1	DEG_SPOP_SBC_1	139:143	VTTSS	SPOP	0.7517	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	601:605	VTTSS	SPOP	0.6705	More...
Q99081	Transcription factor 12	DEG_SPOP_SBC_1	487:491	VTTSS	SPOP	0.994	More...
Q9UMX0	Ubiquilin-1	DEG_SPOP_SBC_1	127:131	VTTSS	SPOP	0.967	More...
Q16473	Putative tenascin-XA	DEG_SPOP_SBC_1	154:158	VTTSS	SPOP	0.8742	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons