DegronMD - Q9UMX0(UBQLN1)

FUNCTION: Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15147878). Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:19822669, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957, PubMed:23459205). Negatively regulates the TICAM1/TRIF-dependent toll-like receptor signaling pathway by decreasing the abundance of TICAM1 via the autophagic pathway (PubMed:21695056). Promotes the ubiquitination and lysosomal degradation of ORAI1, consequently down-regulating the ORAI1-mediated Ca2+ mobilization (PubMed:23307288). Suppresses the maturation and proteasomal degradation of amyloid beta A4 protein (A4) by stimulating the lysine 63 (K63)-linked polyubiquitination. Delays the maturation of A4 by sequestering it in the Golgi apparatus and preventing its transport to the cell surface for subsequent processing (By similarity). Ubiquitinates BCL2L10 and thereby stabilizes protein abundance (PubMed:22233804). {ECO:0000250|UniProtKB:Q9JJP9, ECO:0000269|PubMed:18307982, ECO:0000269|PubMed:19148225, ECO:0000269|PubMed:19822669, ECO:0000269|PubMed:20529957, ECO:0000269|PubMed:21695056, ECO:0000269|PubMed:22233804, ECO:0000269|PubMed:23307288, ECO:0000269|PubMed:23459205, ECO:0000303|PubMed:15147878}.; FUNCTION: [Isoform 1]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). {ECO:0000269|PubMed:18953672, ECO:0000269|PubMed:21143716}.; FUNCTION: [Isoform 2]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress. {ECO:0000269|PubMed:18953672}.; FUNCTION: [Isoform 3]: Plays a role in unfolded protein response (UPR) by attenuating the induction of UPR-inducible genes, DDTI3/CHOP, HSPA5 and PDIA2 during ER stress (PubMed:18953672). Plays a key role in the regulation of the levels of PSEN1 by targeting its accumulation to aggresomes which may then be removed from cells by autophagocytosis (PubMed:21143716). {ECO:0000269|PubMed:18953672, ECO:0000269|PubMed:21143716}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N136T	TCGA-AA-A010	COAD	TCGA	VTTSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.G140D	TCGA-AP-A056	UCEC	TCGA	VTTSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.0833
p.G140D	DO43971	UCEC	ICGC	VTTSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.0833
p.R317I	TCGA-AX-A1CE	UCEC	TCGA	NTSSGE	DEG_Kelch_Keap1_1	302:307	Mutation rewiring degron network	0.0556
p.R317I	DO42280	UCEC	ICGC	NTSSGE	DEG_Kelch_Keap1_1	302:307	Mutation rewiring degron network	0.0556
p.R313H	TCGA-CA-6717	COAD	TCGA	NTSSGE	DEG_Kelch_Keap1_1	302:307	Mutation rewiring degron network	0.1667
p.R313H	DO8264	COAD	ICGC	NTSSGE	DEG_Kelch_Keap1_1	302:307	Mutation rewiring degron network	0.1667
p.P295S	TCGA-D5-6930	COAD	TCGA	NTSSGE	DEG_Kelch_Keap1_1	302:307	Mutation rewiring degron network	0.1389
p.P295S	DO10550	COAD	ICGC	NTSSGE	DEG_Kelch_Keap1_1	302:307	Mutation rewiring degron network	0.1389
p.V127A	TCGA-DI-A1BU	UCEC	TCGA	VTTSS	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.5825
p.V127A	TCGA-F5-6814	READ	TCGA	VTTSS	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.5825
p.V127A	DO36556	READ	ICGC	VTTSS	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.5825
p.V127A	DO42023	UCEC	ICGC	VTTSS	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.5825
p.S305F	TCGA-JX-A3Q0	CESC	TCGA	NTSSGE	DEG_Kelch_Keap1_1	302:307	Mutation altering degron motif	0.7982
p.S305F	DO51607	CESC	ICGC	NTSSGE	DEG_Kelch_Keap1_1	302:307	Mutation altering degron motif	0.7982
p.P133A	DO1129	BRCA	ICGC	VTTSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2778
p.R313C	DO222503	COCA	ICGC	NTSSGE	DEG_Kelch_Keap1_1	302:307	Mutation rewiring degron network	0.1667
p.G306D	DO234370	ESAD	ICGC	NTSSGE	DEG_Kelch_Keap1_1	302:307	Mutation altering degron motif	0.7198
p.T303K	DO229034	LICA	ICGC	NTSSGE	DEG_Kelch_Keap1_1	302:307	Mutation altering degron motif	0.6195
p.N136K	DO229037	LICA	ICGC	VTTSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.S141F	DO52666	MALY	ICGC	VTTSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.0556
p.P133R	DO50729	ORCA	ICGC	VTTSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2778
p.N136S	SIDM00938	Breast Carcinoma	GDSC	VTTSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.N136S	ACH-000902	Breast Cancer	CCLE	VTTSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.N136S	CAL-148	breast	COSMIC	VTTSS	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.R317T	SIDM00633	Breast Carcinoma	GDSC	NTSSGE	DEG_Kelch_Keap1_1	302:307	Mutation rewiring degron network	0.0556
p.R317T	SIDM00630	Breast Carcinoma	GDSC	NTSSGE	DEG_Kelch_Keap1_1	302:307	Mutation rewiring degron network	0.0556
p.R317T	ACH-000759	Breast Cancer	CCLE	NTSSGE	DEG_Kelch_Keap1_1	302:307	Mutation rewiring degron network	0.0556
p.R317T	ACH-000876	Breast Cancer	CCLE	NTSSGE	DEG_Kelch_Keap1_1	302:307	Mutation rewiring degron network	0.0556
p.R317T	MDA-MB-175-VII	breast	COSMIC	NTSSGE	DEG_Kelch_Keap1_1	302:307	Mutation rewiring degron network	0.0556
p.R317T	MDA-MB-415	breast	COSMIC	NTSSGE	DEG_Kelch_Keap1_1	302:307	Mutation rewiring degron network	0.0556
p.S130P	SIDM00654	Small Cell Lung Carcinoma	GDSC	VTTSS	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.6752
p.S130P	ACH-000866	Lung Cancer	CCLE	VTTSS	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.6752
p.S130P	NCI-H1048	lung	COSMIC	VTTSS	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.6752

Kaplan plot for UBQLN1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBQLN1

UniProt ID: Q9UMX0

Entrez ID: 29979

Protein name: Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for UBQLN1 in