DegronMD

Uniprot ID: Q9UMX0

Source protein: Ubiquilin-1

Source gene: UBQLN1

Class: DEG_Kelch_Keap1_1

Location: 302:307

E3 ligase: KEAP1

DEGRON score: 0.9063

ASA_SCORE: 78.4667

COIL: 0.8917

CONS_SCORE: 0.3138

DSS_SCORE: 0.6878

HELIX: 0.0682

FCONS_SCORE: 0.7881

RIG_SCORE: 0.5325

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R317I	TCGA-AX-A1CE	UCEC	TCGA	NTSSGE	DEG_Kelch_Keap1_1	0.0556
p.R317I	DO42280	UCEC	ICGC	NTSSGE	DEG_Kelch_Keap1_1	0.0556
p.R313H	TCGA-CA-6717	COAD	TCGA	NTSSGE	DEG_Kelch_Keap1_1	0.1667
p.R313H	DO8264	COAD	ICGC	NTSSGE	DEG_Kelch_Keap1_1	0.1667
p.P295S	TCGA-D5-6930	COAD	TCGA	NTSSGE	DEG_Kelch_Keap1_1	0.1389
p.P295S	DO10550	COAD	ICGC	NTSSGE	DEG_Kelch_Keap1_1	0.1389
p.S305F	TCGA-JX-A3Q0	CESC	TCGA	NTSSGE	DEG_Kelch_Keap1_1	0.7982
p.S305F	DO51607	CESC	ICGC	NTSSGE	DEG_Kelch_Keap1_1	0.7982
p.R313C	DO222503	COCA	ICGC	NTSSGE	DEG_Kelch_Keap1_1	0.1667
p.G306D	DO234370	ESAD	ICGC	NTSSGE	DEG_Kelch_Keap1_1	0.7198
p.T303K	DO229034	LICA	ICGC	NTSSGE	DEG_Kelch_Keap1_1	0.6195
p.R317T	SIDM00633	Breast Carcinoma	GDSC	NTSSGE	DEG_Kelch_Keap1_1	0.0556
p.R317T	SIDM00630	Breast Carcinoma	GDSC	NTSSGE	DEG_Kelch_Keap1_1	0.0556
p.R317T	ACH-000759	Breast Cancer	CCLE	NTSSGE	DEG_Kelch_Keap1_1	0.0556
p.R317T	ACH-000876	Breast Cancer	CCLE	NTSSGE	DEG_Kelch_Keap1_1	0.0556
p.R317T	MDA-MB-175-VII	breast	COSMIC	NTSSGE	DEG_Kelch_Keap1_1	0.0556
p.R317T	MDA-MB-415	breast	COSMIC	NTSSGE	DEG_Kelch_Keap1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UMX0	Ubiquilin-1	DEG_Kelch_Keap1_1	302:307	NTSSGE	KEAP1	0.9063	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons