DegronMD

Uniprot ID: Q9UMX0

Source protein: Ubiquilin-1

Source gene: UBQLN1

Class: DEG_SPOP_SBC_1

Location: 127:131

E3 ligase: SPOP

DEGRON score: 0.967

ASA_SCORE: 83.24

COIL: 0.9318

CONS_SCORE: 0.291

DSS_SCORE: 0.6802

HELIX: 0.0244

FCONS_SCORE: 1.0086

RIG_SCORE: 0.6214

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N136T	TCGA-AA-A010	COAD	TCGA	VTTSS	DEG_SPOP_SBC_1	0.1944
p.G140D	TCGA-AP-A056	UCEC	TCGA	VTTSS	DEG_SPOP_SBC_1	0.0833
p.G140D	DO43971	UCEC	ICGC	VTTSS	DEG_SPOP_SBC_1	0.0833
p.V127A	TCGA-DI-A1BU	UCEC	TCGA	VTTSS	DEG_SPOP_SBC_1	0.5825
p.V127A	TCGA-F5-6814	READ	TCGA	VTTSS	DEG_SPOP_SBC_1	0.5825
p.V127A	DO36556	READ	ICGC	VTTSS	DEG_SPOP_SBC_1	0.5825
p.V127A	DO42023	UCEC	ICGC	VTTSS	DEG_SPOP_SBC_1	0.5825
p.P133A	DO1129	BRCA	ICGC	VTTSS	DEG_SPOP_SBC_1	0.2778
p.N136K	DO229037	LICA	ICGC	VTTSS	DEG_SPOP_SBC_1	0.1944
p.S141F	DO52666	MALY	ICGC	VTTSS	DEG_SPOP_SBC_1	0.0556
p.P133R	DO50729	ORCA	ICGC	VTTSS	DEG_SPOP_SBC_1	0.2778
p.N136S	SIDM00938	Breast Carcinoma	GDSC	VTTSS	DEG_SPOP_SBC_1	0.1944
p.N136S	ACH-000902	Breast Cancer	CCLE	VTTSS	DEG_SPOP_SBC_1	0.1944
p.N136S	CAL-148	breast	COSMIC	VTTSS	DEG_SPOP_SBC_1	0.1944
p.S130P	SIDM00654	Small Cell Lung Carcinoma	GDSC	VTTSS	DEG_SPOP_SBC_1	0.6752
p.S130P	ACH-000866	Lung Cancer	CCLE	VTTSS	DEG_SPOP_SBC_1	0.6752
p.S130P	NCI-H1048	lung	COSMIC	VTTSS	DEG_SPOP_SBC_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22105	Tenascin-X	DEG_SPOP_SBC_1	3666:3670	VTTSS	SPOP	0.8858	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	607:611	VTTSS	SPOP	0.9514	More...
Q14119	Vascular endothelial zinc finger 1	DEG_SPOP_SBC_1	139:143	VTTSS	SPOP	0.7517	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	601:605	VTTSS	SPOP	0.6705	More...
Q99081	Transcription factor 12	DEG_SPOP_SBC_1	487:491	VTTSS	SPOP	0.994	More...
Q9UMX0	Ubiquilin-1	DEG_SPOP_SBC_1	127:131	VTTSS	SPOP	0.967	More...
Q16473	Putative tenascin-XA	DEG_SPOP_SBC_1	154:158	VTTSS	SPOP	0.8742	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons