DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 601:605

E3 ligase: SPOP

DEGRON score: 0.6705

ASA_SCORE: 85.48

COIL: 0.864

CONS_SCORE: 0.5236

DSS_SCORE: 0.5465

HELIX: 0.019

FCONS_SCORE: 1

RIG_SCORE: 0.7104

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A595T	TCGA-DA-A95V	SKCM	TCGA	VTTSS	DEG_SPOP_SBC_1	0.1667
p.A595T	DO219478	SKCM	ICGC	VTTSS	DEG_SPOP_SBC_1	0.1667
p.E606K	TCGA-EE-A2MJ	SKCM	TCGA	VTTSS	DEG_SPOP_SBC_1	0.3056
p.E606K	DO38099	SKCM	ICGC	VTTSS	DEG_SPOP_SBC_1	0.3056
p.T599N	TCGA-EY-A1G8	UCEC	TCGA	VTTSS	DEG_SPOP_SBC_1	0.2778
p.T599N	DO43578	UCEC	ICGC	VTTSS	DEG_SPOP_SBC_1	0.2778
p.N598K	TCGA-L5-A8NN	ESCA	TCGA	VTTSS	DEG_SPOP_SBC_1	0.25
p.D596Y	DO23396	LINC	ICGC	VTTSS	DEG_SPOP_SBC_1	0.1944
p.V601E	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	VTTSS	DEG_SPOP_SBC_1	0.7693
p.V601E	ACH-000851	Lung Cancer	CCLE	VTTSS	DEG_SPOP_SBC_1	0.7693

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22105	Tenascin-X	DEG_SPOP_SBC_1	3666:3670	VTTSS	SPOP	0.8858	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	607:611	VTTSS	SPOP	0.9514	More...
Q14119	Vascular endothelial zinc finger 1	DEG_SPOP_SBC_1	139:143	VTTSS	SPOP	0.7517	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	601:605	VTTSS	SPOP	0.6705	More...
Q99081	Transcription factor 12	DEG_SPOP_SBC_1	487:491	VTTSS	SPOP	0.994	More...
Q9UMX0	Ubiquilin-1	DEG_SPOP_SBC_1	127:131	VTTSS	SPOP	0.967	More...
Q16473	Putative tenascin-XA	DEG_SPOP_SBC_1	154:158	VTTSS	SPOP	0.8742	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons