DegronMD

Uniprot ID: Q14119

Source protein: Vascular endothelial zinc finger 1

Source gene: VEZF1

Class: DEG_SPOP_SBC_1

Location: 139:143

E3 ligase: SPOP

DEGRON score: 0.7517

ASA_SCORE: 70.92

COIL: 0.5236

CONS_SCORE: 0.5432

DSS_SCORE: 0.4228

HELIX: 0.0074

FCONS_SCORE: 1.138

RIG_SCORE: 0.687

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A133V	TCGA-G4-6588	COAD	TCGA	VTTSS	DEG_SPOP_SBC_1	0.1667
p.A133V	DO10140	COAD	ICGC	VTTSS	DEG_SPOP_SBC_1	0.1667
p.L136V	TCGA-YC-A89H	BLCA	TCGA	VTTSS	DEG_SPOP_SBC_1	0.25
p.L136V	DO51948	BLCA	ICGC	VTTSS	DEG_SPOP_SBC_1	0.25
p.V129I	SIDM00217	Colorectal Carcinoma	GDSC	VTTSS	DEG_SPOP_SBC_1	0.0556
p.V129I	ACH-000999	Colon/Colorectal Cancer	CCLE	VTTSS	DEG_SPOP_SBC_1	0.0556
p.V129I	SNU-1040	large_intestine	COSMIC	VTTSS	DEG_SPOP_SBC_1	0.0556
p.S130L	ACH-000973	Bladder Cancer	CCLE	VTTSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22105	Tenascin-X	DEG_SPOP_SBC_1	3666:3670	VTTSS	SPOP	0.8858	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	607:611	VTTSS	SPOP	0.9514	More...
Q14119	Vascular endothelial zinc finger 1	DEG_SPOP_SBC_1	139:143	VTTSS	SPOP	0.7517	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	601:605	VTTSS	SPOP	0.6705	More...
Q99081	Transcription factor 12	DEG_SPOP_SBC_1	487:491	VTTSS	SPOP	0.994	More...
Q9UMX0	Ubiquilin-1	DEG_SPOP_SBC_1	127:131	VTTSS	SPOP	0.967	More...
Q16473	Putative tenascin-XA	DEG_SPOP_SBC_1	154:158	VTTSS	SPOP	0.8742	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons