DegronMD

Uniprot ID: Q99081

Source protein: Transcription factor 12

Source gene: TCF12

Class: DEG_SPOP_SBC_1

Location: 487:491

E3 ligase: SPOP

DEGRON score: 0.994

ASA_SCORE: 83.28

COIL: 0.9168

CONS_SCORE: 0.3852

DSS_SCORE: 0.5617

HELIX: 0.041

FCONS_SCORE: 1.1623

RIG_SCORE: 0.6964

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L480F	TCGA-2W-A8YY	CESC	TCGA	VTTSS	DEG_SPOP_SBC_1	0.1389
p.R494W	TCGA-AA-A022	COAD	TCGA	VTTSS	DEG_SPOP_SBC_1	0.25
p.S488L	TCGA-D3-A8GI	SKCM	TCGA	VTTSS	DEG_SPOP_SBC_1	0.7667
p.R494L	TCGA-EE-A184	SKCM	TCGA	VTTSS	DEG_SPOP_SBC_1	0.25
p.R489I	DO18056	KIRC	ICGC	VTTSS	DEG_SPOP_SBC_1	0.8102
p.A479V	DO41752	UCEC	ICGC	VTTSS	DEG_SPOP_SBC_1	0.1111
p.A479V	CW-2	large_intestine	COSMIC	VTTSS	DEG_SPOP_SBC_1	0.1111
p.N492Y	NCI-H64	lung	COSMIC	VTTSS	DEG_SPOP_SBC_1	0.3056
p.N492Y	NCI-H1436	lung	COSMIC	VTTSS	DEG_SPOP_SBC_1	0.3056
p.N495K	HDQ-P1	breast	COSMIC	VTTSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22105	Tenascin-X	DEG_SPOP_SBC_1	3666:3670	VTTSS	SPOP	0.8858	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	607:611	VTTSS	SPOP	0.9514	More...
Q14119	Vascular endothelial zinc finger 1	DEG_SPOP_SBC_1	139:143	VTTSS	SPOP	0.7517	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	601:605	VTTSS	SPOP	0.6705	More...
Q99081	Transcription factor 12	DEG_SPOP_SBC_1	487:491	VTTSS	SPOP	0.994	More...
Q9UMX0	Ubiquilin-1	DEG_SPOP_SBC_1	127:131	VTTSS	SPOP	0.967	More...
Q16473	Putative tenascin-XA	DEG_SPOP_SBC_1	154:158	VTTSS	SPOP	0.8742	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons