DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VTTSS
Uniprot ID:
Q16473
Source protein:
Putative tenascin-XA
Source gene:
TNXA
Class:
DEG_SPOP_SBC_1
Location:
154:158
E3 ligase:
SPOP
DEGRON score:
0.8742
ASA_SCORE:
56.06
COIL:
0.5652
CONS_SCORE:
0
DSS_SCORE:
0.3565
HELIX:
0.0028
FCONS_SCORE:
0
RIG_SCORE:
0.7826
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with TNXA mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P22105
Tenascin-X
DEG_SPOP_SBC_1
3666:3670
VTTSS
SPOP
0.8858
More...
P54259
Atrophin-1
DEG_SPOP_SBC_1
607:611
VTTSS
SPOP
0.9514
More...
Q14119
Vascular endothelial zinc finger 1
DEG_SPOP_SBC_1
139:143
VTTSS
SPOP
0.7517
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
601:605
VTTSS
SPOP
0.6705
More...
Q99081
Transcription factor 12
DEG_SPOP_SBC_1
487:491
VTTSS
SPOP
0.994
More...
Q9UMX0
Ubiquilin-1
DEG_SPOP_SBC_1
127:131
VTTSS
SPOP
0.967
More...
Q16473
Putative tenascin-XA
DEG_SPOP_SBC_1
154:158
VTTSS
SPOP
0.8742
More...