DegronMD

Uniprot ID: P54259

Source protein: Atrophin-1

Source gene: ATN1

Class: DEG_SPOP_SBC_1

Location: 384:388

E3 ligase: SPOP

DEGRON score: 0.991

ASA_SCORE: 86.78

COIL: 0.9552

CONS_SCORE: 0.3146

DSS_SCORE: 0.4047

HELIX: 0.0362

FCONS_SCORE: 0.6871

RIG_SCORE: 0.4627

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S393C	TCGA-C4-A0F1	BLCA	TCGA	AASSS	DEG_SPOP_SBC_1	0.1944
p.S393C	DO581	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	0.1944
p.S394P	TCGA-DI-A1BU	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	0.1667
p.S394P	DO42023	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	0.1667
p.S395C	TCGA-XF-A9SI	BLCA	TCGA	AASSS	DEG_SPOP_SBC_1	0.1389
p.S395C	DO51914	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	0.1389
p.S382C	DO48378	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	0.2778
p.S395F	DO233732	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	0.1389
p.S386L	DO222731	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	0.7667
p.P398L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	0.0556
p.P398L	ACH-000983	Leukemia	CCLE	AASSS	DEG_SPOP_SBC_1	0.0556
p.P398L	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	0.0556
p.P398A	SIDM00950	Pancreatic Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	0.0556
p.P398A	ACH-000243	Pancreatic Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	0.0556
p.P398A	DAN-G	pancreas	COSMIC	AASSS	DEG_SPOP_SBC_1	0.0556
p.S380G	ACH-001484	Leukemia	CCLE	AASSS	DEG_SPOP_SBC_1	0.2222
p.S380G	ACH-001485	Leukemia	CCLE	AASSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00499	Myc box-dependent-interacting protein 1	DEG_SPOP_SBC_1	485:489	AASSS	SPOP	0.8705	More...
O15479	Melanoma-associated antigen B2	DEG_SPOP_SBC_1	49:53	AASSS	SPOP	0.9937	More...
O15553	Pyrin	DEG_SPOP_SBC_1	105:109	AASSS	SPOP	0.7892	More...
O60248	Protein SOX-15	DEG_SPOP_SBC_1	22:26	AASSS	SPOP	0.9164	More...
O60346	PH domain leucine-rich repeat-containing protein phosphatase 1	DEG_SPOP_SBC_1	136:140	AASSS	SPOP	0.9558	More...
O60583	Cyclin-T2	DEG_SPOP_SBC_1	472:476	AASSS	SPOP	0.9676	More...
O60641	Clathrin coat assembly protein AP180	DEG_SPOP_SBC_1	659:663	AASSS	SPOP	0.6805	More...
O94851	[F-actin]-monooxygenase MICAL2	DEG_SPOP_SBC_1	912:916	AASSS	SPOP	0.9916	More...
O95568	Histidine protein methyltransferase 1 homolog	DEG_SPOP_SBC_1	81:85	AASSS	SPOP	0.9977	More...
P10275	Androgen receptor	DEG_SPOP_SBC_1	430:434	AASSS	SPOP	0.9407	More...
P20585	DNA mismatch repair protein Msh3	DEG_SPOP_SBC_1	12:16	AASSS	SPOP	0.986	More...
P20810	Calpastatin	DEG_SPOP_SBC_1	679:683	AASSS	SPOP	0.9948	More...
P22004	Bone morphogenetic protein 6	DEG_SPOP_SBC_1	165:169	AASSS	SPOP	0.8116	More...
P30305	M-phase inducer phosphatase 2	DEG_SPOP_SBC_1	184:188	AASSS	SPOP	0.9962	More...
P35568	Insulin receptor substrate 1	DEG_SPOP_SBC_1	1033:1037	AASSS	SPOP	0.9986	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1289:1293	AASSS	SPOP	0.9466	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1650:1654	AASSS	SPOP	0.9741	More...
P42684	Tyrosine-protein kinase ABL2	DEG_SPOP_SBC_1	559:563	AASSS	SPOP	0.6475	More...
P43357	Melanoma-associated antigen 3	DEG_SPOP_SBC_1	38:42	AASSS	SPOP	0.9939	More...
P43360	Melanoma-associated antigen 6	DEG_SPOP_SBC_1	38:42	AASSS	SPOP	0.9773	More...
P43361	Melanoma-associated antigen 8	DEG_SPOP_SBC_1	38:42	AASSS	SPOP	0.7662	More...
P46019	Phosphorylase b kinase regulatory subunit alpha, liver isoform	DEG_SPOP_SBC_1	1026:1030	AASSS	SPOP	0.5327	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	898:902	AASSS	SPOP	0.9984	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	384:388	AASSS	SPOP	0.991	More...
P55316	Forkhead box protein G1	DEG_SPOP_SBC_1	438:442	AASSS	SPOP	0.9093	More...
P56975	Pro-neuregulin-3, membrane-bound isoform	DEG_SPOP_SBC_1	250:254	AASSS	SPOP	0.9841	More...
P61927	60S ribosomal protein L37	DEG_SPOP_SBC_1	92:96	AASSS	SPOP	0.9084	More...
Q01831	DNA repair protein complementing XP-C cells	DEG_SPOP_SBC_1	499:503	AASSS	SPOP	0.9944	More...
Q03001	Dystonin	DEG_SPOP_SBC_1	1138:1142	AASSS	SPOP	0.7435	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	83:87	AASSS	SPOP	0.9662	More...
Q12837	POU domain, class 4, transcription factor 2	DEG_SPOP_SBC_1	153:157	AASSS	SPOP	0.983	More...
Q12952	Forkhead box protein L1	DEG_SPOP_SBC_1	299:303	AASSS	SPOP	0.7842	More...
Q13724	Mannosyl-oligosaccharide glucosidase	DEG_SPOP_SBC_1	732:736	AASSS	SPOP	0.5289	More...
Q14978	Nucleolar and coiled-body phosphoprotein 1	DEG_SPOP_SBC_1	214:218	AASSS	SPOP	0.9951	More...
Q15464	SH2 domain-containing adapter protein B	DEG_SPOP_SBC_1	149:153	AASSS	SPOP	0.9824	More...
Q15542	Transcription initiation factor TFIID subunit 5	DEG_SPOP_SBC_1	52:56	AASSS	SPOP	0.9584	More...
Q5SYB0	FERM and PDZ domain-containing protein 1	DEG_SPOP_SBC_1	961:965	AASSS	SPOP	0.9852	More...
Q6DN14	Multiple C2 and transmembrane domain-containing protein 1	DEG_SPOP_SBC_1	15:19	AASSS	SPOP	0.8517	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	1592:1596	AASSS	SPOP	0.9141	More...
Q6T4R5	Nance-Horan syndrome protein	DEG_SPOP_SBC_1	1609:1613	AASSS	SPOP	0.9991	More...
Q6VY07	Phosphofurin acidic cluster sorting protein 1	DEG_SPOP_SBC_1	64:68	AASSS	SPOP	0.9354	More...
Q6ZN18	Zinc finger protein AEBP2	DEG_SPOP_SBC_1	144:148	AASSS	SPOP	0.9629	More...
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SPOP_SBC_1	1574:1578	AASSS	SPOP	0.9757	More...
Q7Z6L0	Proline-rich transmembrane protein 2	DEG_SPOP_SBC_1	2:6	AASSS	SPOP	0.9253	More...
Q86UU5	Gametogenetin	DEG_SPOP_SBC_1	257:261	AASSS	SPOP	0.9823	More...
Q86VV8	Rotatin	DEG_SPOP_SBC_1	332:336	AASSS	SPOP	0.9967	More...
Q8NFJ9	Bardet-Biedl syndrome 1 protein	DEG_SPOP_SBC_1	3:7	AASSS	SPOP	0.8652	More...
Q8WYL5	Protein phosphatase Slingshot homolog 1	DEG_SPOP_SBC_1	14:18	AASSS	SPOP	0.9962	More...
Q92538	Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1	DEG_SPOP_SBC_1	1776:1780	AASSS	SPOP	0.9973	More...
Q92574	Hamartin	DEG_SPOP_SBC_1	522:526	AASSS	SPOP	0.9658	More...
Q96DE5	Anaphase-promoting complex subunit 16	DEG_SPOP_SBC_1	2:6	AASSS	SPOP	0.8429	More...
Q96G42	Kelch domain-containing protein 7B	DEG_SPOP_SBC_1	116:120	AASSS	SPOP	0.8839	More...
Q96JA1	Leucine-rich repeats and immunoglobulin-like domains protein 1	DEG_SPOP_SBC_1	518:522	AASSS	SPOP	0.8568	More...
Q96SF7	T-box transcription factor TBX15	DEG_SPOP_SBC_1	486:490	AASSS	SPOP	0.8965	More...
Q99961	Endophilin-A2	DEG_SPOP_SBC_1	284:288	AASSS	SPOP	0.9979	More...
Q9BYZ6	Rho-related BTB domain-containing protein 2	DEG_SPOP_SBC_1	714:718	AASSS	SPOP	0.8373	More...
Q9C0C2	182 kDa tankyrase-1-binding protein	DEG_SPOP_SBC_1	1461:1465	AASSS	SPOP	0.6113	More...
Q9H1R2	Dual specificity protein phosphatase 15	DEG_SPOP_SBC_1	288:292	AASSS	SPOP	0.9533	More...
Q9H329	Band 4.1-like protein 4B	DEG_SPOP_SBC_1	44:48	AASSS	SPOP	0.8189	More...
Q9H7D7	WD repeat-containing protein 26	DEG_SPOP_SBC_1	100:104	AASSS	SPOP	0.5491	More...
Q9H7N4	Splicing factor, arginine/serine-rich 19	DEG_SPOP_SBC_1	756:760	AASSS	SPOP	0.9395	More...
Q9H992	E3 ubiquitin-protein ligase MARCHF7	DEG_SPOP_SBC_1	452:456	AASSS	SPOP	0.9985	More...
Q9HCS4	Transcription factor 7-like 1	DEG_SPOP_SBC_1	528:532	AASSS	SPOP	0.9989	More...
Q9NPJ6	Mediator of RNA polymerase II transcription subunit 4	DEG_SPOP_SBC_1	2:6	AASSS	SPOP	0.9835	More...
Q9P1Z0	Zinc finger and BTB domain-containing protein 4	DEG_SPOP_SBC_1	83:87	AASSS	SPOP	0.9243	More...
Q9UF56	F-box/LRR-repeat protein 17	DEG_SPOP_SBC_1	93:97	AASSS	SPOP	0.5855	More...
Q9UHC7	E3 ubiquitin-protein ligase makorin-1	DEG_SPOP_SBC_1	129:133	AASSS	SPOP	0.9977	More...
Q9ULJ3	Zinc finger and BTB domain-containing protein 21	DEG_SPOP_SBC_1	456:460	AASSS	SPOP	0.9581	More...
Q9Y2K2	Serine/threonine-protein kinase SIK3	DEG_SPOP_SBC_1	762:766	AASSS	SPOP	0.9175	More...
Q9Y4H2	Insulin receptor substrate 2	DEG_SPOP_SBC_1	942:946	AASSS	SPOP	0.9702	More...
Q13434	Putative E3 ubiquitin-protein ligase makorin-4	DEG_SPOP_SBC_1	164:168	AASSS	SPOP	0.6889	More...
Q66K41	Zinc finger protein 385C	DEG_SPOP_SBC_1	176:180	AASSS	SPOP	0.974	More...
Q96PE2	Rho guanine nucleotide exchange factor 17	DEG_SPOP_SBC_1	247:251	AASSS	SPOP	0.9823	More...
Q9P206	Uncharacterized protein KIAA1522	DEG_SPOP_SBC_1	757:761	AASSS	SPOP	0.9809	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	169:173	AASSS	SPOP	0.9418	More...
Q09019	Dystrophia myotonica WD repeat-containing protein	DEG_SPOP_SBC_1	472:476	AASSS	SPOP	0.541	More...
Q5TGY3	AT-hook DNA-binding motif-containing protein 1	DEG_SPOP_SBC_1	1084:1088	AASSS	SPOP	0.9765	More...
Q6UWI4	Protein shisa-2 homolog	DEG_SPOP_SBC_1	184:188	AASSS	SPOP	0.9934	More...
Q6ZU65	Ubinuclein-2	DEG_SPOP_SBC_1	738:742	AASSS	SPOP	0.991	More...
Q6ZU67	BEN domain-containing protein 4	DEG_SPOP_SBC_1	96:100	AASSS	SPOP	0.9824	More...
Q6ZU67	BEN domain-containing protein 4	DEG_SPOP_SBC_1	125:129	AASSS	SPOP	0.9934	More...
Q7Z5M5	Transmembrane channel-like protein 3	DEG_SPOP_SBC_1	1046:1050	AASSS	SPOP	0.9343	More...
Q86XZ4	Spermatogenesis-associated serine-rich protein 2	DEG_SPOP_SBC_1	400:404	AASSS	SPOP	0.9733	More...
Q8WWW8	GRB2-associated-binding protein 3	DEG_SPOP_SBC_1	151:155	AASSS	SPOP	0.9574	More...
Q9Y2H5	Pleckstrin homology domain-containing family A member 6	DEG_SPOP_SBC_1	439:443	AASSS	SPOP	0.5059	More...
Q5BKY9	Protein FAM133B	DEG_SPOP_SBC_1	239:243	AASSS	SPOP	0.7438	More...
Q6P1R3	Myb/SANT-like DNA-binding domain-containing protein 2	DEG_SPOP_SBC_1	75:79	AASSS	SPOP	0.9629	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AASSS

Degron related mutations and impact score

Drug responses associated with ATN1 mutations

All proteins holding degron of AASSS