DegronMD - Q15542(TAF5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N420D	TCGA-CA-6717	COAD	TCGA	NRIPLPELK	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.1944
p.N420D	DO8264	COAD	ICGC	NRIPLPELK	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.1944
p.P423H	TCGA-CK-5913	COAD	TCGA	NRIPLPELK	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.2778
p.P423H	DO8826	COAD	ICGC	NRIPLPELK	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.2778
p.N425K	TCGA-D6-6516	HNSC	TCGA	NRIPLPELK	DEG_APCC_DBOX_1	425:433	Mutation altering degron motif	0.5806
p.N425K	DO15623	HNSC	ICGC	NRIPLPELK	DEG_APCC_DBOX_1	425:433	Mutation altering degron motif	0.5806
p.D418Y	TCGA-JX-A3Q0	CESC	TCGA	NRIPLPELK	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.1389
p.D418Y	DO51607	CESC	ICGC	NRIPLPELK	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.1389
p.D439A	DO233673	GACA	ICGC	NRIPLPELK	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.1667
p.P428S	DO222702	MELA	ICGC	NRIPLPELK	DEG_APCC_DBOX_1	425:433	Mutation altering degron motif	0.5641
p.P428L	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	NRIPLPELK	DEG_APCC_DBOX_1	425:433	Mutation altering degron motif	0.6471
p.P428L	ACH-002062	Lymphoma	CCLE	NRIPLPELK	DEG_APCC_DBOX_1	425:433	Mutation altering degron motif	0.6471
p.P428L	SLVL	haematopoietic and lymphoid tissue	COSMIC	NRIPLPELK	DEG_APCC_DBOX_1	425:433	Mutation altering degron motif	0.6471
p.D439N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	NRIPLPELK	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.1667
p.D439N	ACH-001127	Leukemia	CCLE	NRIPLPELK	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.1667
p.D439N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	NRIPLPELK	DEG_APCC_DBOX_1	425:433	Mutation rewiring degron network	0.1667
p.S54A	ACH-000966	Ovarian Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	52:56	Mutation altering degron motif	0.7588

Kaplan plot for TAF5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TAF5

UniProt ID: Q15542

Entrez ID: 6877

Protein name: Transcription initiation factor TFIID subunit 5 (Transcription initiation factor TFIID 100 kDa subunit) (TAF(II)100) (TAFII-100) (TAFII100)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TAF5 in