DegronMD

Uniprot ID: Q15542

Source protein: Transcription initiation factor TFIID subunit 5

Source gene: TAF5

Class: DEG_APCC_DBOX_1

Location: 425:433

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9963

ASA_SCORE: 67.9667

COIL: 0.8443

CONS_SCORE: 0.5648

DSS_SCORE: 0.7383

HELIX: 0.0779

FCONS_SCORE: 1.3027

RIG_SCORE: 0.6736

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N420D	TCGA-CA-6717	COAD	TCGA	NRIPLPELK	DEG_APCC_DBOX_1	0.1944
p.N420D	DO8264	COAD	ICGC	NRIPLPELK	DEG_APCC_DBOX_1	0.1944
p.P423H	TCGA-CK-5913	COAD	TCGA	NRIPLPELK	DEG_APCC_DBOX_1	0.2778
p.P423H	DO8826	COAD	ICGC	NRIPLPELK	DEG_APCC_DBOX_1	0.2778
p.N425K	TCGA-D6-6516	HNSC	TCGA	NRIPLPELK	DEG_APCC_DBOX_1	0.5806
p.N425K	DO15623	HNSC	ICGC	NRIPLPELK	DEG_APCC_DBOX_1	0.5806
p.D418Y	TCGA-JX-A3Q0	CESC	TCGA	NRIPLPELK	DEG_APCC_DBOX_1	0.1389
p.D418Y	DO51607	CESC	ICGC	NRIPLPELK	DEG_APCC_DBOX_1	0.1389
p.D439A	DO233673	GACA	ICGC	NRIPLPELK	DEG_APCC_DBOX_1	0.1667
p.P428S	DO222702	MELA	ICGC	NRIPLPELK	DEG_APCC_DBOX_1	0.5641
p.P428L	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	NRIPLPELK	DEG_APCC_DBOX_1	0.6471
p.P428L	ACH-002062	Lymphoma	CCLE	NRIPLPELK	DEG_APCC_DBOX_1	0.6471
p.P428L	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	NRIPLPELK	DEG_APCC_DBOX_1	0.6471
p.D439N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	NRIPLPELK	DEG_APCC_DBOX_1	0.1667
p.D439N	ACH-001127	Leukemia	CCLE	NRIPLPELK	DEG_APCC_DBOX_1	0.1667
p.D439N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	NRIPLPELK	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15542	Transcription initiation factor TFIID subunit 5	DEG_APCC_DBOX_1	425:433	NRIPLPELK	APC,CDC20,FZR1	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons