DegronMD - Q14978(NOLC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D228Y	TCGA-05-4390	LUAD	TCGA	AASSS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.0556
p.E275Q	TCGA-22-5491	LUSC	TCGA	NKPGPYSSVP	CBL_PTK	284:293	Mutation rewiring degron network	0.0833
p.S433R	TCGA-24-2254	OV	TCGA	ADSSS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.1111
p.E360Q	TCGA-A2-A0YD	BRCA	TCGA	AESSS	DEG_SPOP_SBC_1	359:363	Mutation altering degron motif	0.5633
p.T418M	TCGA-AA-3672	COAD	TCGA	ADSSS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.25
p.T418M	TCGA-AA-A01R	COAD	TCGA	ADSSS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.25
p.M282T	TCGA-CG-4305	STAD	TCGA	NKPGPYSSVP	CBL_PTK	284:293	Mutation rewiring degron network	0.2778
p.S290G	TCGA-CG-4460	STAD	TCGA	NKPGPYSSVP	CBL_PTK	284:293	Mutation altering degron motif	0.8104
p.K280N	TCGA-HU-8604	STAD	TCGA	NKPGPYSSVP	CBL_PTK	284:293	Mutation substituting flanking lysine	0.3333
p.S227N	TCGA-JY-A93E	ESCA	TCGA	AASSS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.0833
p.G412S	TCGA-VQ-A91D	STAD	TCGA	ADSSS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.0833
p.E276K	TCGA-W3-A828	SKCM	TCGA	NKPGPYSSVP	CBL_PTK	284:293	Mutation rewiring degron network	0.1111
p.E361Q	DO5710	BRCA	ICGC	AESSS	DEG_SPOP_SBC_1	359:363	Mutation altering degron motif	0.6744
p.T419M	DO9010	COAD	ICGC	ADSSS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.2778
p.T419M	DO7934	COAD	ICGC	ADSSS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.2778
p.S367T	DO233259	GACA	ICGC	AESSS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.2222
p.Y290C	DO233872	GACA	ICGC	NKPGPYSSVP	CBL_PTK	284:293	Mutation altering degron motif	0.7087
p.S217I	DO228976	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	214:218	Mutation altering degron motif	0.8453
p.A207S	DO229034	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.1389
p.A422S	DO229035	LICA	ICGC	ADSSS	DEG_SPOP_SBC_1	421:425	Mutation altering degron motif	0.7588
p.E276Q	DO26420	LUSC	ICGC	NKPGPYSSVP	CBL_PTK	284:293	Mutation rewiring degron network	0.1111
p.P289L	DO220906	MELA	ICGC	NKPGPYSSVP	CBL_PTK	284:293	Mutation altering degron motif	0.7582
p.S434R	DO29156	OV	ICGC	ADSSS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.0833
p.P295Q	DO32980	PACA	ICGC	NKPGPYSSVP	CBL_PTK	284:293	Mutation rewiring degron network	0.2778
p.K209E	DO35270	PACA	ICGC	AASSS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.1944
p.P282T	DO35330	PACA	ICGC	NKPGPYSSVP	CBL_PTK	284:293	Mutation rewiring degron network	0.2778
p.P282T	DO229224	THCA	ICGC	NKPGPYSSVP	CBL_PTK	284:293	Mutation rewiring degron network	0.2778
p.E277K	DO51273	SKCM	ICGC	NKPGPYSSVP	CBL_PTK	284:293	Mutation rewiring degron network	0.1389
p.M283T	DO38823	STAD	ICGC	NKPGPYSSVP	CBL_PTK	284:293	Mutation rewiring degron network	0.3056
p.S291G	DO38427	STAD	ICGC	NKPGPYSSVP	CBL_PTK	284:293	Mutation altering degron motif	0.6993
p.G413S	DO51783	STAD	ICGC	ADSSS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.1111
p.K281N	DO47907	STAD	ICGC	NKPGPYSSVP	CBL_PTK	284:293	Mutation rewiring degron network	0.25
p.M292I	SIDM01016	T-Lymphoblastic Leukemia	GDSC	NKPGPYSSVP	CBL_PTK	284:293	Mutation altering degron motif	0.7618
p.M292I	Jurkat	haematopoietic and lymphoid tissue	COSMIC	NKPGPYSSVP	CBL_PTK	284:293	Mutation altering degron motif	0.7618
p.S225I	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.1389
p.S225I	ACH-000945	Lung Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	214:218	Mutation rewiring degron network	0.1389
p.L427M	SIDM00153	T-Lymphoblastic Leukemia	GDSC	ADSSS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.2778
p.A413V	SIDM01729	Endometrial Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.1111
p.S303T	ACH-000407	Endometrial/Uterine Cancer	CCLE	NKPGPYSSVP	CBL_PTK	284:293	Mutation blocking phosphorylation signal	0.5
p.S430N	ACH-000692	Head and Neck Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.1944
p.L417M	ACH-000964	Leukemia	CCLE	ADSSS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.2222
p.E372K	ACH-000974	Endometrial/Uterine Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.0833
p.E372K	SNG-M	endometrium	COSMIC	AESSS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.0833
p.M282I	ACH-000995	Leukemia	CCLE	NKPGPYSSVP	CBL_PTK	284:293	Mutation rewiring degron network	0.2778
p.M282I	Jurkat	haematopoietic and lymphoid tissue	COSMIC	NKPGPYSSVP	CBL_PTK	284:293	Mutation rewiring degron network	0.2778
p.P293S	ACH-001568	Skin Cancer	CCLE	NKPGPYSSVP	CBL_PTK	284:293	Mutation altering degron motif	0.6752
p.M283I	Jurkat	haematopoietic and lymphoid tissue	COSMIC	NKPGPYSSVP	CBL_PTK	284:293	Mutation rewiring degron network	0.3056
p.E373K	SNG-M	endometrium	COSMIC	AESSS	DEG_SPOP_SBC_1	359:363	Mutation rewiring degron network	0.0556

Kaplan plot for NOLC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NOLC1

UniProt ID: Q14978

Entrez ID: 9221

Protein name: Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NOLC1 in