DegronMD

Uniprot ID: Q14978

Source protein: Nucleolar and coiled-body phosphoprotein 1

Source gene: NOLC1

Class: CBL_PTK

Location: 284:293

E3 ligase: CBL

DEGRON score: 0.9334

ASA_SCORE: 105.99

COIL: 0.969

CONS_SCORE: 0.4209

DSS_SCORE: 0.7978

HELIX: 0.0118

FCONS_SCORE: 0.9328

RIG_SCORE: 0.475

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E275Q	TCGA-22-5491	LUSC	TCGA	NKPGPYSSVP	CBL_PTK	0.0833
p.M282T	TCGA-CG-4305	STAD	TCGA	NKPGPYSSVP	CBL_PTK	0.2778
p.S290G	TCGA-CG-4460	STAD	TCGA	NKPGPYSSVP	CBL_PTK	0.8104
p.K280N	TCGA-HU-8604	STAD	TCGA	NKPGPYSSVP	CBL_PTK	0.3333
p.E276K	TCGA-W3-A828	SKCM	TCGA	NKPGPYSSVP	CBL_PTK	0.1111
p.Y290C	DO233872	GACA	ICGC	NKPGPYSSVP	CBL_PTK	0.7087
p.E276Q	DO26420	LUSC	ICGC	NKPGPYSSVP	CBL_PTK	0.1111
p.P289L	DO220906	MELA	ICGC	NKPGPYSSVP	CBL_PTK	0.7582
p.P295Q	DO32980	PACA	ICGC	NKPGPYSSVP	CBL_PTK	0.2778
p.P282T	DO35330	PACA	ICGC	NKPGPYSSVP	CBL_PTK	0.2778
p.P282T	DO229224	THCA	ICGC	NKPGPYSSVP	CBL_PTK	0.2778
p.E277K	DO51273	SKCM	ICGC	NKPGPYSSVP	CBL_PTK	0.1389
p.M283T	DO38823	STAD	ICGC	NKPGPYSSVP	CBL_PTK	0.3056
p.S291G	DO38427	STAD	ICGC	NKPGPYSSVP	CBL_PTK	0.6993
p.K281N	DO47907	STAD	ICGC	NKPGPYSSVP	CBL_PTK	0.25
p.M292I	SIDM01016	T-Lymphoblastic Leukemia	GDSC	NKPGPYSSVP	CBL_PTK	0.7618
p.M292I	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	NKPGPYSSVP	CBL_PTK	0.7618
p.S303T	ACH-000407	Endometrial/Uterine Cancer	CCLE	NKPGPYSSVP	CBL_PTK	0.5
p.M282I	ACH-000995	Leukemia	CCLE	NKPGPYSSVP	CBL_PTK	0.2778
p.M282I	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	NKPGPYSSVP	CBL_PTK	0.2778
p.P293S	ACH-001568	Skin Cancer	CCLE	NKPGPYSSVP	CBL_PTK	0.6752
p.M283I	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	NKPGPYSSVP	CBL_PTK	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14978	Nucleolar and coiled-body phosphoprotein 1	CBL_PTK	284:293	NKPGPYSSVP	CBL	0.9334	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons