DegronMD - Q99961(SH3GL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R297W	TCGA-2F-A9KP	BLCA	TCGA	PIRTPSRS	DEG_SCF_FBW7_1	295:302	Mutation altering degron motif	0.7523
p.R297W	SIDM00255	Neuroblastoma	GDSC	PIRTPSRS	DEG_SCF_FBW7_1	295:302	Mutation altering degron motif	0.7523
p.K294N	TCGA-85-8071	LUSC	TCGA	AASSS	DEG_SPOP_SBC_1	284:288	Mutation substituting flanking lysine	0.2778
p.T278I	TCGA-A5-A1OF	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1667
p.A280T	TCGA-B5-A3FA	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.2222
p.K282N	TCGA-C5-A1M7	CESC	TCGA	AASSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.2778
p.P309L	TCGA-CG-5728	STAD	TCGA	PIRTPSRS	DEG_SCF_FBW7_1	295:302	Mutation rewiring degron network	0.1389
p.R301W	TCGA-CM-6674	COAD	TCGA	PIRTPSRS	DEG_SCF_FBW7_1	295:302	Mutation altering degron motif	0.7523
p.A285V	TCGA-E3-A3E1	THCA	TCGA	AASSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.5825
p.P299T	TCGA-EM-A2CN	THCA	TCGA	PIRTPSRS	DEG_SCF_FBW7_1	295:302	Mutation altering degron motif	0.7031
p.C277Y	TCGA-EY-A1GS	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1389
p.I296M	TCGA-JW-A5VL	CESC	TCGA	PIRTPSRS	DEG_SCF_FBW7_1	295:302	Mutation altering degron motif	0.6507
p.L306R	TCGA-OR-A5LO	ACC	TCGA	PIRTPSRS	DEG_SCF_FBW7_1	295:302	Mutation rewiring degron network	0.2222
p.L293P	DO230311	COCA	ICGC	PIRTPSRS	DEG_SCF_FBW7_1	295:302	Mutation rewiring degron network	0.2778
p.L293P	DO230311	COCA	ICGC	AASSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1944
p.E281K	DO234462	ESAD	ICGC	AASSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.25
p.P292Q	DO15278	HNSC	ICGC	PIRTPSRS	DEG_SCF_FBW7_1	295:302	Mutation blocking phosphorylation signal	0.6944
p.P292Q	DO15278	HNSC	ICGC	AASSS	DEG_SPOP_SBC_1	284:288	Mutation blocking phosphorylation signal	0.6667
p.P292Q	DO37794	SKCM	ICGC	PIRTPSRS	DEG_SCF_FBW7_1	295:302	Mutation blocking phosphorylation signal	0.6944
p.P292Q	DO37794	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	284:288	Mutation blocking phosphorylation signal	0.6667
p.S294R	DO229052	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	284:288	Mutation substituting flanking lysine	0.2778
p.A284T	SIDM01144	Gastric Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7139
p.A284T	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7139
p.A284T	SIDM00357	Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7139
p.A284T	SIDM00363	Acute Myeloid Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7139
p.A284T	EBC-1	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7139
p.A284T	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7139
p.A284T	RERF-LC-FM	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7139
p.A284T	NCI-SNU-5	stomach	COSMIC	AASSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7139
p.S287P	SIDM00889	Cervical Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7863
p.S287P	ACH-001333	Cervical Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7863
p.S287P	C-33-A	cervix	COSMIC	AASSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7863
p.P304S	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PIRTPSRS	DEG_SCF_FBW7_1	295:302	Mutation rewiring degron network	0.2778
p.P304S	NCI-H1155	lung	COSMIC	PIRTPSRS	DEG_SCF_FBW7_1	295:302	Mutation rewiring degron network	0.2778
p.F279L	JHH-2	liver	COSMIC	AASSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1944
p.F279L	HSC-39	stomach	COSMIC	AASSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1944
p.G275R	SNU-C2B	large intestine	COSMIC	AASSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.0833

Kaplan plot for SH3GL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH3GL1

UniProt ID: Q99961

Entrez ID: 6455

Protein name: Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SH3GL1 in