DegronMD

Uniprot ID: Q99961

Source protein: Endophilin-A2

Source gene: SH3GL1

Class: DEG_SCF_FBW7_1

Location: 295:302

E3 ligase: FBXW7

DEGRON score: 0.9162

ASA_SCORE: 83.9375

COIL: 0.8773

CONS_SCORE: 0.3424

DSS_SCORE: 0.7125

HELIX: 0.031

FCONS_SCORE: 1.0224

RIG_SCORE: 0.6125

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R297W	TCGA-2F-A9KP	BLCA	TCGA	PIRTPSRS	DEG_SCF_FBW7_1	0.7523
p.R297W	SIDM00255	Neuroblastoma	GDSC	PIRTPSRS	DEG_SCF_FBW7_1	0.7523
p.P309L	TCGA-CG-5728	STAD	TCGA	PIRTPSRS	DEG_SCF_FBW7_1	0.1389
p.R301W	TCGA-CM-6674	COAD	TCGA	PIRTPSRS	DEG_SCF_FBW7_1	0.7523
p.P299T	TCGA-EM-A2CN	THCA	TCGA	PIRTPSRS	DEG_SCF_FBW7_1	0.7031
p.I296M	TCGA-JW-A5VL	CESC	TCGA	PIRTPSRS	DEG_SCF_FBW7_1	0.6507
p.L306R	TCGA-OR-A5LO	ACC	TCGA	PIRTPSRS	DEG_SCF_FBW7_1	0.2222
p.L293P	DO230311	COCA	ICGC	PIRTPSRS	DEG_SCF_FBW7_1	0.2778
p.P292Q	DO15278	HNSC	ICGC	PIRTPSRS	DEG_SCF_FBW7_1	0.6944
p.P292Q	DO37794	SKCM	ICGC	PIRTPSRS	DEG_SCF_FBW7_1	0.6944
p.P304S	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PIRTPSRS	DEG_SCF_FBW7_1	0.2778
p.P304S	NCI-H1155	lung	COSMIC	PIRTPSRS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99961	Endophilin-A2	DEG_SCF_FBW7_1	295:302	PIRTPSRS	FBXW7	0.9162	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons