DegronMD - P46019(PHKA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1048K	TCGA-34-5929	LUSC	TCGA	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.1389
p.T1048K	DO26659	LUSC	ICGC	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.1389
p.A1031V	TCGA-AM-5821	COAD	TCGA	AASSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.3056
p.A1031V	TCGA-AM-5821	COAD	TCGA	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.1667
p.A1031V	DO8240	COAD	ICGC	AASSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.3056
p.A1031V	DO8240	COAD	ICGC	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.1667
p.A1031V	SIDM00216	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.3056
p.A1031V	SIDM00216	Colorectal Carcinoma	GDSC	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.1667
p.A1031V	ACH-000989	Colon/Colorectal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.3056
p.A1031V	ACH-000989	Colon/Colorectal Cancer	CCLE	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.1667
p.A1031V	SNU-175	large intestine	COSMIC	AASSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.3056
p.A1031V	SNU-175	large intestine	COSMIC	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.1667
p.P1042L	TCGA-AP-A1DK	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.3056
p.P1042L	DO42033	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.3056
p.A1037V	TCGA-AX-A2HD	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.5825
p.A1037V	DO42608	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.5825
p.H726Q	TCGA-AX-A2HK	UCEC	TCGA	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation altering degron motif	0.647
p.H726Q	DO42889	UCEC	ICGC	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation altering degron motif	0.647
p.S1039Y	TCGA-BK-A6W3	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.712
p.S1039Y	DO50076	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.712
p.E1018K	TCGA-DF-A2KV	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.1111
p.E1018K	TCGA-ZF-AA51	BLCA	TCGA	AASSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.1111
p.E1018K	DO219093	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.1111
p.E1018K	DO219771	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.1111
p.P678S	TCGA-DK-AA6W	BLCA	TCGA	LRSYLPPLC	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.5641
p.P678S	DO219009	BLCA	ICGC	LRSYLPPLC	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.5641
p.F1020L	TCGA-EI-6917	READ	TCGA	AASSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.1667
p.F1020L	DO36881	READ	ICGC	AASSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.1667
p.A1027V	TCGA-L5-A8NE	ESCA	TCGA	AASSS	DEG_SPOP_SBC_1	1026:1030	Mutation altering degron motif	0.5825
p.R687H	TCGA-P5-A77W	LGG	TCGA	LRSYLPPLC	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.1667
p.R687H	DO223680	LGG	ICGC	LRSYLPPLC	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.1667
p.S1039F	TCGA-QB-AA9O	SKCM	TCGA	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7982
p.S1039F	DO51267	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7982
p.A725G	TCGA-QN-A5NN	UCS	TCGA	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation rewiring degron network	0.3056
p.G1024C	TCGA-SL-A6JA	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.2778
p.G1024C	DO219787	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.2778
p.D686E	DO225217	BRCA	ICGC	LRSYLPPLC	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.1944
p.D686E	DO227566	BRCA	ICGC	LRSYLPPLC	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.1944
p.L677M	DO228900	LICA	ICGC	LRSYLPPLC	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.711
p.P719Q	DO228974	LICA	ICGC	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation rewiring degron network	0.1389
p.P736H	DO229029	LICA	ICGC	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation rewiring degron network	0.2778
p.K728I	DO229029	LICA	ICGC	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation altering degron motif	0.642
p.P738T	DO229028	LICA	ICGC	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation rewiring degron network	0.2222
p.H726N	DO229022	LICA	ICGC	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation altering degron motif	0.6312
p.P678T	DO229037	LICA	ICGC	LRSYLPPLC	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.5919
p.N683K	DO229045	LICA	ICGC	LRSYLPPLC	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.2778
p.K742R	DO229211	THCA	ICGC	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation blocking ubiquitination signal	0.5556
p.S1040N	DO229211	THCA	ICGC	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7069
p.P719S	SIDM01004	Chronic Myelogenous Leukemia	GDSC	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation rewiring degron network	0.1389
p.P719S	ACH-000983	Leukemia	CCLE	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation rewiring degron network	0.1389
p.P719S	KCL-22	haematopoietic and lymphoid tissue	COSMIC	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation rewiring degron network	0.1389
p.R727C	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation altering degron motif	0.8301
p.R727C	VAL	haematopoietic and lymphoid tissue	COSMIC	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation altering degron motif	0.8301
p.L740Q	SIDM01464	Pancreatic Carcinoma	GDSC	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation rewiring degron network	0.1667
p.L740Q	ACH-000502	Pancreatic Cancer	CCLE	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHKA2

UniProt ID: P46019

Entrez ID: 5256

Protein name: Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHKA2 in