DegronMD - P46019(PHKA2)

FUNCTION: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.

GO - Biological processes (BP): carbohydrate metabolic process [GO:0005975]; cellular protein modification process [GO:0006464]; generation of precursor metabolites and energy [GO:0006091]; glycogen metabolic process [GO:0005977]

GO - Molecular function (MF): calmodulin binding [GO:0005516]; phosphorylase kinase activity [GO:0004689]

GO - Cellular component (CC): cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]; plasma membrane [GO:0005886]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
LRSYLPPLC	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Phosphorylase b kinase regulatory subunit alpha, liver isoform	673:681	More..
HRKSLNLVD	DEG_APCC_DBOX_1	APC,CDC20,FZR1	Phosphorylase b kinase regulatory subunit alpha, liver isoform	726:734	More..
AASSS	DEG_SPOP_SBC_1	SPOP	Phosphorylase b kinase regulatory subunit alpha, liver isoform	1026:1030	More..
ARSST	DEG_SPOP_SBC_1	SPOP	Phosphorylase b kinase regulatory subunit alpha, liver isoform	1037:1041	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R727C	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation altering degron motif	0.8301
p.R727C	VAL	haematopoietic and lymphoid tissue	COSMIC	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation altering degron motif	0.8301
p.S1039F	TCGA-QB-AA9O	SKCM	TCGA	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7982
p.S1039F	DO51267	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7982
p.S1039Y	TCGA-BK-A6W3	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.712
p.S1039Y	DO50076	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.712
p.L677M	DO228900	LICA	ICGC	LRSYLPPLC	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.711
p.S1040N	DO229211	THCA	ICGC	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7069
p.H726Q	TCGA-AX-A2HK	UCEC	TCGA	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation altering degron motif	0.647
p.H726Q	DO42889	UCEC	ICGC	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation altering degron motif	0.647
p.K728I	DO229029	LICA	ICGC	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation altering degron motif	0.642
p.H726N	DO229022	LICA	ICGC	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation altering degron motif	0.6312
p.P678T	DO229037	LICA	ICGC	LRSYLPPLC	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.5919
p.A1037V	TCGA-AX-A2HD	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.5825
p.A1037V	DO42608	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.5825
p.A1027V	TCGA-L5-A8NE	ESCA	TCGA	AASSS	DEG_SPOP_SBC_1	1026:1030	Mutation altering degron motif	0.5825
p.P678S	TCGA-DK-AA6W	BLCA	TCGA	LRSYLPPLC	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.5641
p.P678S	DO219009	BLCA	ICGC	LRSYLPPLC	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.5641
p.K742R	DO229211	THCA	ICGC	HRKSLNLVD	DEG_APCC_DBOX_1	726:734	Mutation blocking ubiquitination signal	0.5556
p.A1031V	TCGA-AM-5821	COAD	TCGA	AASSS	DEG_SPOP_SBC_1	1026:1030	Mutation rewiring degron network	0.3056

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHKA2

UniProt ID: P46019

Entrez ID: 5256

Protein name: Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHKA2 in