DegronMD

Uniprot ID: P46019

Source protein: Phosphorylase b kinase regulatory subunit alpha, liver isoform

Source gene: PHKA2

Class: DEG_APCC_DBOX_1

Location: 673:681

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8865

ASA_SCORE: 77.5444

COIL: 0.7978

CONS_SCORE: 0.3019

DSS_SCORE: 0.2842

HELIX: 0.1322

FCONS_SCORE: 0.9321

RIG_SCORE: 0.7547

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P678S	TCGA-DK-AA6W	BLCA	TCGA	LRSYLPPLC	DEG_APCC_DBOX_1	0.5641
p.P678S	DO219009	BLCA	ICGC	LRSYLPPLC	DEG_APCC_DBOX_1	0.5641
p.R687H	TCGA-P5-A77W	LGG	TCGA	LRSYLPPLC	DEG_APCC_DBOX_1	0.1667
p.R687H	DO223680	LGG	ICGC	LRSYLPPLC	DEG_APCC_DBOX_1	0.1667
p.D686E	DO225217	BRCA	ICGC	LRSYLPPLC	DEG_APCC_DBOX_1	0.1944
p.D686E	DO227566	BRCA	ICGC	LRSYLPPLC	DEG_APCC_DBOX_1	0.1944
p.L677M	DO228900	LICA	ICGC	LRSYLPPLC	DEG_APCC_DBOX_1	0.711
p.P678T	DO229037	LICA	ICGC	LRSYLPPLC	DEG_APCC_DBOX_1	0.5919
p.N683K	DO229045	LICA	ICGC	LRSYLPPLC	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46019	Phosphorylase b kinase regulatory subunit alpha, liver isoform	DEG_APCC_DBOX_1	673:681	LRSYLPPLC	APC,CDC20,FZR1	0.8865	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons