DegronMD

Uniprot ID: P46019

Source protein: Phosphorylase b kinase regulatory subunit alpha, liver isoform

Source gene: PHKA2

Class: DEG_APCC_DBOX_1

Location: 726:734

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9979

ASA_SCORE: 87.6667

COIL: 0.7198

CONS_SCORE: 0.4001

DSS_SCORE: 0.3759

HELIX: 0.2132

FCONS_SCORE: 1.2398

RIG_SCORE: 0.7429

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H726Q	TCGA-AX-A2HK	UCEC	TCGA	HRKSLNLVD	DEG_APCC_DBOX_1	0.647
p.H726Q	DO42889	UCEC	ICGC	HRKSLNLVD	DEG_APCC_DBOX_1	0.647
p.A725G	TCGA-QN-A5NN	UCS	TCGA	HRKSLNLVD	DEG_APCC_DBOX_1	0.3056
p.P719Q	DO228974	LICA	ICGC	HRKSLNLVD	DEG_APCC_DBOX_1	0.1389
p.P736H	DO229029	LICA	ICGC	HRKSLNLVD	DEG_APCC_DBOX_1	0.2778
p.K728I	DO229029	LICA	ICGC	HRKSLNLVD	DEG_APCC_DBOX_1	0.642
p.P738T	DO229028	LICA	ICGC	HRKSLNLVD	DEG_APCC_DBOX_1	0.2222
p.H726N	DO229022	LICA	ICGC	HRKSLNLVD	DEG_APCC_DBOX_1	0.6312
p.K742R	DO229211	THCA	ICGC	HRKSLNLVD	DEG_APCC_DBOX_1	0.5556
p.P719S	SIDM01004	Chronic Myelogenous Leukemia	GDSC	HRKSLNLVD	DEG_APCC_DBOX_1	0.1389
p.P719S	ACH-000983	Leukemia	CCLE	HRKSLNLVD	DEG_APCC_DBOX_1	0.1389
p.P719S	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	HRKSLNLVD	DEG_APCC_DBOX_1	0.1389
p.R727C	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	HRKSLNLVD	DEG_APCC_DBOX_1	0.8301
p.R727C	VAL	haematopoietic_and_lymphoid_tissue	COSMIC	HRKSLNLVD	DEG_APCC_DBOX_1	0.8301
p.L740Q	SIDM01464	Pancreatic Carcinoma	GDSC	HRKSLNLVD	DEG_APCC_DBOX_1	0.1667
p.L740Q	ACH-000502	Pancreatic Cancer	CCLE	HRKSLNLVD	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46019	Phosphorylase b kinase regulatory subunit alpha, liver isoform	DEG_APCC_DBOX_1	726:734	HRKSLNLVD	APC,CDC20,FZR1	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons