DegronMD

Uniprot ID: P46019

Source protein: Phosphorylase b kinase regulatory subunit alpha, liver isoform

Source gene: PHKA2

Class: DEG_SPOP_SBC_1

Location: 1037:1041

E3 ligase: SPOP

DEGRON score: 0.6157

ASA_SCORE: 91.32

COIL: 0.8912

CONS_SCORE: 0.3176

DSS_SCORE: 0.6876

HELIX: 0.0454

FCONS_SCORE: 1.0913

RIG_SCORE: 0.4974

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1048K	TCGA-34-5929	LUSC	TCGA	ARSST	DEG_SPOP_SBC_1	0.1389
p.T1048K	DO26659	LUSC	ICGC	ARSST	DEG_SPOP_SBC_1	0.1389
p.A1031V	TCGA-AM-5821	COAD	TCGA	ARSST	DEG_SPOP_SBC_1	0.1667
p.A1031V	DO8240	COAD	ICGC	ARSST	DEG_SPOP_SBC_1	0.1667
p.A1031V	SIDM00216	Colorectal Carcinoma	GDSC	ARSST	DEG_SPOP_SBC_1	0.1667
p.A1031V	ACH-000989	Colon/Colorectal Cancer	CCLE	ARSST	DEG_SPOP_SBC_1	0.1667
p.A1031V	SNU-175	large_intestine	COSMIC	ARSST	DEG_SPOP_SBC_1	0.1667
p.P1042L	TCGA-AP-A1DK	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	0.3056
p.P1042L	DO42033	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	0.3056
p.A1037V	TCGA-AX-A2HD	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	0.5825
p.A1037V	DO42608	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	0.5825
p.S1039Y	TCGA-BK-A6W3	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	0.712
p.S1039Y	DO50076	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	0.712
p.S1039F	TCGA-QB-AA9O	SKCM	TCGA	ARSST	DEG_SPOP_SBC_1	0.7982
p.S1039F	DO51267	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	0.7982
p.S1040N	DO229211	THCA	ICGC	ARSST	DEG_SPOP_SBC_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95817	BAG family molecular chaperone regulator 3	DEG_SPOP_SBC_1	281:285	ARSST	SPOP	0.9272	More...
P46019	Phosphorylase b kinase regulatory subunit alpha, liver isoform	DEG_SPOP_SBC_1	1037:1041	ARSST	SPOP	0.6157	More...
Q15788	Nuclear receptor coactivator 1	DEG_SPOP_SBC_1	401:405	ARSST	SPOP	0.9779	More...
Q5T619	Zinc finger protein 648	DEG_SPOP_SBC_1	486:490	ARSST	SPOP	0.9232	More...
Q96BA8	Cyclic AMP-responsive element-binding protein 3-like protein 1	DEG_SPOP_SBC_1	235:239	ARSST	SPOP	0.7129	More...
Q96PU5	E3 ubiquitin-protein ligase NEDD4-like	DEG_SPOP_SBC_1	363:367	ARSST	SPOP	0.9797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons