DegronMD

Uniprot ID: Q15788

Source protein: Nuclear receptor coactivator 1

Source gene: NCOA1

Class: DEG_SPOP_SBC_1

Location: 401:405

E3 ligase: SPOP

DEGRON score: 0.9779

ASA_SCORE: 91.44

COIL: 0.909

CONS_SCORE: 0.4104

DSS_SCORE: 0.6577

HELIX: 0.0504

FCONS_SCORE: 0.988

RIG_SCORE: 0.6172

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M413I	TCGA-EO-A22R	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	0.1111
p.M413I	DO42713	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	0.1111
p.R402P	DO48369	BLCA	ICGC	ARSST	DEG_SPOP_SBC_1	0.6401
p.R402H	DO233731	GACA	ICGC	ARSST	DEG_SPOP_SBC_1	0.7133
p.P408T	DO229213	THCA	ICGC	ARSST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95817	BAG family molecular chaperone regulator 3	DEG_SPOP_SBC_1	281:285	ARSST	SPOP	0.9272	More...
P46019	Phosphorylase b kinase regulatory subunit alpha, liver isoform	DEG_SPOP_SBC_1	1037:1041	ARSST	SPOP	0.6157	More...
Q15788	Nuclear receptor coactivator 1	DEG_SPOP_SBC_1	401:405	ARSST	SPOP	0.9779	More...
Q5T619	Zinc finger protein 648	DEG_SPOP_SBC_1	486:490	ARSST	SPOP	0.9232	More...
Q96BA8	Cyclic AMP-responsive element-binding protein 3-like protein 1	DEG_SPOP_SBC_1	235:239	ARSST	SPOP	0.7129	More...
Q96PU5	E3 ubiquitin-protein ligase NEDD4-like	DEG_SPOP_SBC_1	363:367	ARSST	SPOP	0.9797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons