DegronMD - Q15788(NCOA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S540Y	TCGA-06-5416	GBM	TCGA	NNNNRSYSNIP	CBL_PTK	527:537	Mutation rewiring degron network	0.25
p.S540Y	DO10880	GBM	ICGC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation rewiring degron network	0.25
p.S1275F	TCGA-2H-A9GN	ESCA	TCGA	LQQTPPAS	DEG_SCF_FBW7_1	1268:1275	Mutation altering degron motif	0.7982
p.S1275F	SIDM00545	Melanoma	GDSC	LQQTPPAS	DEG_SCF_FBW7_1	1268:1275	Mutation altering degron motif	0.7982
p.S1275F	ACH-000987	Skin Cancer	CCLE	LQQTPPAS	DEG_SCF_FBW7_1	1268:1275	Mutation altering degron motif	0.7982
p.S1275F	Mewo	skin	COSMIC	LQQTPPAS	DEG_SCF_FBW7_1	1268:1275	Mutation altering degron motif	0.7982
p.Q1270E	TCGA-55-A4DF	LUAD	TCGA	LQQTPPAS	DEG_SCF_FBW7_1	1268:1275	Mutation altering degron motif	0.5633
p.Q1270E	DO45318	LUAD	ICGC	LQQTPPAS	DEG_SCF_FBW7_1	1268:1275	Mutation altering degron motif	0.5633
p.E757D	TCGA-AP-A056	UCEC	TCGA	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation rewiring degron network	0.25
p.E757D	DO43971	UCEC	ICGC	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation rewiring degron network	0.25
p.G1174C	TCGA-BF-A1PZ	SKCM	TCGA	PGTPPAS	DEG_SCF_FBW7_1	1177:1183	Mutation rewiring degron network	0.25
p.G1174C	TCGA-BF-A1PZ	SKCM	TCGA	PASTS	DEG_SPOP_SBC_1	1181:1185	Mutation rewiring degron network	0.1389
p.G1174C	TCGA-BF-A1PZ	SKCM	TCGA	PPNY	ITCH	1170:1173	Mutation rewiring degron network	0.3056
p.G1174C	DO50279	SKCM	ICGC	PGTPPAS	DEG_SCF_FBW7_1	1177:1183	Mutation rewiring degron network	0.25
p.G1174C	DO50279	SKCM	ICGC	PASTS	DEG_SPOP_SBC_1	1181:1185	Mutation rewiring degron network	0.1389
p.G1174C	DO50279	SKCM	ICGC	PPNY	ITCH	1170:1173	Mutation rewiring degron network	0.3056
p.P1194L	TCGA-BG-A222	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	1181:1185	Mutation rewiring degron network	0.0833
p.P1194L	DO42977	UCEC	ICGC	PASTS	DEG_SPOP_SBC_1	1181:1185	Mutation rewiring degron network	0.0833
p.K758N	TCGA-BS-A0TC	UCEC	TCGA	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation rewiring degron network	0.2778
p.K758N	DO42400	UCEC	ICGC	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation rewiring degron network	0.2778
p.S1266Y	TCGA-BS-A0UV	UCEC	TCGA	LQQTPPAS	DEG_SCF_FBW7_1	1268:1275	Mutation rewiring degron network	0.2778
p.S1266Y	DO42793	UCEC	ICGC	LQQTPPAS	DEG_SCF_FBW7_1	1268:1275	Mutation rewiring degron network	0.2778
p.G1162S	TCGA-CD-8528	STAD	TCGA	PPNY	ITCH	1170:1173	Mutation rewiring degron network	0.1111
p.G1162S	DO47729	STAD	ICGC	PPNY	ITCH	1170:1173	Mutation rewiring degron network	0.1111
p.L766M	TCGA-CK-5916	COAD	TCGA	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation altering degron motif	0.5999
p.L766M	TCGA-EE-A3AC	SKCM	TCGA	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation altering degron motif	0.5999
p.L766M	DO8786	COAD	ICGC	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation altering degron motif	0.5999
p.L766M	DO37631	SKCM	ICGC	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation altering degron motif	0.5999
p.N545D	TCGA-CV-7097	HNSC	TCGA	NNNNRSYSNIP	CBL_PTK	527:537	Mutation rewiring degron network	0.1111
p.N545D	DO14886	HNSC	ICGC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation rewiring degron network	0.1111
p.P518S	TCGA-CV-7568	HNSC	TCGA	NNNNRSYSNIP	CBL_PTK	527:537	Mutation rewiring degron network	0.0833
p.P518S	DO14160	HNSC	ICGC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation rewiring degron network	0.0833
p.V519I	TCGA-DK-A3WW	BLCA	TCGA	NNNNRSYSNIP	CBL_PTK	527:537	Mutation rewiring degron network	0.1111
p.V519I	DO481	BLCA	ICGC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation rewiring degron network	0.1111
p.V519I	SIDM01107	Melanoma	GDSC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation rewiring degron network	0.1111
p.V519I	ACH-000465	Skin Cancer	CCLE	NNNNRSYSNIP	CBL_PTK	527:537	Mutation rewiring degron network	0.1111
p.V519I	SK-MEL-1	skin	COSMIC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation rewiring degron network	0.1111
p.M413I	TCGA-EO-A22R	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.1111
p.M413I	DO42713	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.1111
p.R531Q	TCGA-EO-A22X	UCEC	TCGA	NNNNRSYSNIP	CBL_PTK	527:537	Mutation altering degron motif	0.6218
p.R531Q	DO43907	UCEC	ICGC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation altering degron motif	0.6218
p.L760V	TCGA-EO-A3AV	UCEC	TCGA	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation altering degron motif	0.5654
p.L760V	DO52412	UCEC	ICGC	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation altering degron motif	0.5654
p.L752V	TCGA-GV-A6ZA	BLCA	TCGA	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation rewiring degron network	0.1111
p.L752V	DO49776	BLCA	ICGC	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation rewiring degron network	0.1111
p.W1285L	TCGA-NC-A5HN	LUSC	TCGA	LQQTPPAS	DEG_SCF_FBW7_1	1268:1275	Mutation rewiring degron network	0.0556
p.W1285L	DO52025	LUSC	ICGC	LQQTPPAS	DEG_SCF_FBW7_1	1268:1275	Mutation rewiring degron network	0.0556
p.N527D	TCGA-PK-A5HB	ACC	TCGA	NNNNRSYSNIP	CBL_PTK	527:537	Mutation altering degron motif	0.5821
p.L768V	TCGA-RC-A7SH	LIHC	TCGA	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation rewiring degron network	0.3056
p.L768V	DO52312	LIHC	ICGC	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation rewiring degron network	0.3056
p.Q1270K	TCGA-RE-A7BO	ESCA	TCGA	LQQTPPAS	DEG_SCF_FBW7_1	1268:1275	Mutation altering degron motif	0.5833
p.R402P	DO48369	BLCA	ICGC	ARSST	DEG_SPOP_SBC_1	401:405	Mutation altering degron motif	0.6401
p.E546K	DO224768	BRCA	ICGC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation rewiring degron network	0.0833
p.N535S	DO222762	COCA	ICGC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation altering degron motif	0.5958
p.E776K	DO222800	COCA	ICGC	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation rewiring degron network	0.0833
p.R750C	DO233732	GACA	ICGC	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation rewiring degron network	0.0556
p.R402H	DO233731	GACA	ICGC	ARSST	DEG_SPOP_SBC_1	401:405	Mutation altering degron motif	0.7133
p.Y1173F	DO228278	LICA	ICGC	PPNY	ITCH	1170:1173	Mutation altering degron motif	0.7528
p.Q1278H	DO228948	LICA	ICGC	LQQTPPAS	DEG_SCF_FBW7_1	1268:1275	Mutation rewiring degron network	0.25
p.P1262L	DO232842	NACA	ICGC	LQQTPPAS	DEG_SCF_FBW7_1	1268:1275	Mutation rewiring degron network	0.1667
p.S1185C	DO46897	RECA	ICGC	PASTS	DEG_SPOP_SBC_1	1181:1185	Mutation altering degron motif	0.8652
p.P1186S	DO229453	SKCA	ICGC	PGTPPAS	DEG_SCF_FBW7_1	1177:1183	Mutation rewiring degron network	0.25
p.P1186S	DO229453	SKCA	ICGC	PASTS	DEG_SPOP_SBC_1	1181:1185	Mutation rewiring degron network	0.3056
p.P408T	DO229213	THCA	ICGC	ARSST	DEG_SPOP_SBC_1	401:405	Mutation rewiring degron network	0.25
p.S517T	DO229540	UTCA	ICGC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation blocking phosphorylation signal	0.5
p.S534A	SIDM02026	Colorectal Carcinoma	GDSC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation altering degron motif	0.7588
p.P1180L	SIDM00617	Hepatocellular Carcinoma	GDSC	PGTPPAS	DEG_SCF_FBW7_1	1177:1183	Mutation altering degron motif	0.7582
p.P1180L	JHH-2	liver	COSMIC	PGTPPAS	DEG_SCF_FBW7_1	1177:1183	Mutation altering degron motif	0.7582
p.V775L	SIDM01095	Rhabdomyosarcoma	GDSC	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation rewiring degron network	0.1111
p.V775L	ACH-000833	Sarcoma	CCLE	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation rewiring degron network	0.1111
p.V775L	SJRH30	soft tissue	COSMIC	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation rewiring degron network	0.1111
p.P537S	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation altering degron motif	0.6752
p.P537S	ACH-001363	Lung Cancer	CCLE	NNNNRSYSNIP	CBL_PTK	527:537	Mutation altering degron motif	0.6752
p.P537S	NCI-H2135	lung	COSMIC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation altering degron motif	0.6752
p.Y533D	SIDM00568	Gastric Carcinoma	GDSC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation altering degron motif	0.7325
p.Y533D	OCUM-1	stomach	COSMIC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation altering degron motif	0.7325
p.E757A	ACH-000996	Endometrial/Uterine Cancer	CCLE	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation rewiring degron network	0.25
p.R541W	SNU-175	large intestine	COSMIC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation rewiring degron network	0.2222
p.L539P	NB13	autonomic ganglia	COSMIC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation rewiring degron network	0.2778
p.C767Y	RKN	ovary	COSMIC	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation altering degron motif	0.7087
p.S531L	NCI-H1944	lung	COSMIC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation altering degron motif	0.7667
p.A1185T	Farage	haematopoietic and lymphoid tissue	COSMIC	PASTS	DEG_SPOP_SBC_1	1181:1185	Mutation altering degron motif	0.7139
p.L539R	HCC2998	large intestine	COSMIC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation rewiring degron network	0.2778
p.D763H	HDQ-P1	breast	COSMIC	LRSTPNLS	DEG_SCF_FBW7_1	760:767	Mutation altering degron motif	0.7688
p.S517F	MKN7	stomach	COSMIC	NNNNRSYSNIP	CBL_PTK	527:537	Mutation blocking phosphorylation signal	0.5

Kaplan plot for NCOA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NCOA1

UniProt ID: Q15788

Entrez ID: 8648

Protein name: Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NCOA1 in