DegronMD

Uniprot ID: Q15788

Source protein: Nuclear receptor coactivator 1

Source gene: NCOA1

Class: DEG_SCF_FBW7_1

Location: 760:767

E3 ligase: FBXW7

DEGRON score: 0.5906

ASA_SCORE: 80.225

COIL: 0.7854

CONS_SCORE: 0.4217

DSS_SCORE: 0.4503

HELIX: 0.1774

FCONS_SCORE: 0.6086

RIG_SCORE: 0.6893

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E757D	TCGA-AP-A056	UCEC	TCGA	LRSTPNLS	DEG_SCF_FBW7_1	0.25
p.E757D	DO43971	UCEC	ICGC	LRSTPNLS	DEG_SCF_FBW7_1	0.25
p.K758N	TCGA-BS-A0TC	UCEC	TCGA	LRSTPNLS	DEG_SCF_FBW7_1	0.2778
p.K758N	DO42400	UCEC	ICGC	LRSTPNLS	DEG_SCF_FBW7_1	0.2778
p.L766M	TCGA-CK-5916	COAD	TCGA	LRSTPNLS	DEG_SCF_FBW7_1	0.5999
p.L766M	TCGA-EE-A3AC	SKCM	TCGA	LRSTPNLS	DEG_SCF_FBW7_1	0.5999
p.L766M	DO8786	COAD	ICGC	LRSTPNLS	DEG_SCF_FBW7_1	0.5999
p.L766M	DO37631	SKCM	ICGC	LRSTPNLS	DEG_SCF_FBW7_1	0.5999
p.L760V	TCGA-EO-A3AV	UCEC	TCGA	LRSTPNLS	DEG_SCF_FBW7_1	0.5654
p.L760V	DO52412	UCEC	ICGC	LRSTPNLS	DEG_SCF_FBW7_1	0.5654
p.L752V	TCGA-GV-A6ZA	BLCA	TCGA	LRSTPNLS	DEG_SCF_FBW7_1	0.1111
p.L752V	DO49776	BLCA	ICGC	LRSTPNLS	DEG_SCF_FBW7_1	0.1111
p.L768V	TCGA-RC-A7SH	LIHC	TCGA	LRSTPNLS	DEG_SCF_FBW7_1	0.3056
p.L768V	DO52312	LIHC	ICGC	LRSTPNLS	DEG_SCF_FBW7_1	0.3056
p.E776K	DO222800	COCA	ICGC	LRSTPNLS	DEG_SCF_FBW7_1	0.0833
p.R750C	DO233732	GACA	ICGC	LRSTPNLS	DEG_SCF_FBW7_1	0.0556
p.V775L	SIDM01095	Rhabdomyosarcoma	GDSC	LRSTPNLS	DEG_SCF_FBW7_1	0.1111
p.V775L	ACH-000833	Sarcoma	CCLE	LRSTPNLS	DEG_SCF_FBW7_1	0.1111
p.V775L	SJRH30	soft_tissue	COSMIC	LRSTPNLS	DEG_SCF_FBW7_1	0.1111
p.E757A	ACH-000996	Endometrial/Uterine Cancer	CCLE	LRSTPNLS	DEG_SCF_FBW7_1	0.25
p.C767Y	RKN	ovary	COSMIC	LRSTPNLS	DEG_SCF_FBW7_1	0.7087
p.D763H	HDQ-P1	breast	COSMIC	LRSTPNLS	DEG_SCF_FBW7_1	0.7688

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15788	Nuclear receptor coactivator 1	DEG_SCF_FBW7_1	760:767	LRSTPNLS	FBXW7	0.5906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons