DegronMD

Uniprot ID: Q15788

Source protein: Nuclear receptor coactivator 1

Source gene: NCOA1

Class: DEG_SCF_FBW7_1

Location: 1268:1275

E3 ligase: FBXW7

DEGRON score: 0.9965

ASA_SCORE: 90.8125

COIL: 0.94

CONS_SCORE: 0.5885

DSS_SCORE: 0.7102

HELIX: 0.041

FCONS_SCORE: 1.0608

RIG_SCORE: 0.6254

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1275F	TCGA-2H-A9GN	ESCA	TCGA	LQQTPPAS	DEG_SCF_FBW7_1	0.7982
p.S1275F	SIDM00545	Melanoma	GDSC	LQQTPPAS	DEG_SCF_FBW7_1	0.7982
p.S1275F	ACH-000987	Skin Cancer	CCLE	LQQTPPAS	DEG_SCF_FBW7_1	0.7982
p.S1275F	Mewo	skin	COSMIC	LQQTPPAS	DEG_SCF_FBW7_1	0.7982
p.Q1270E	TCGA-55-A4DF	LUAD	TCGA	LQQTPPAS	DEG_SCF_FBW7_1	0.5633
p.Q1270E	DO45318	LUAD	ICGC	LQQTPPAS	DEG_SCF_FBW7_1	0.5633
p.S1266Y	TCGA-BS-A0UV	UCEC	TCGA	LQQTPPAS	DEG_SCF_FBW7_1	0.2778
p.S1266Y	DO42793	UCEC	ICGC	LQQTPPAS	DEG_SCF_FBW7_1	0.2778
p.W1285L	TCGA-NC-A5HN	LUSC	TCGA	LQQTPPAS	DEG_SCF_FBW7_1	0.0556
p.W1285L	DO52025	LUSC	ICGC	LQQTPPAS	DEG_SCF_FBW7_1	0.0556
p.Q1270K	TCGA-RE-A7BO	ESCA	TCGA	LQQTPPAS	DEG_SCF_FBW7_1	0.5833
p.Q1278H	DO228948	LICA	ICGC	LQQTPPAS	DEG_SCF_FBW7_1	0.25
p.P1262L	DO232842	NACA	ICGC	LQQTPPAS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15788	Nuclear receptor coactivator 1	DEG_SCF_FBW7_1	1268:1275	LQQTPPAS	FBXW7	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons