DegronMD

Uniprot ID: Q15788

Source protein: Nuclear receptor coactivator 1

Source gene: NCOA1

Class: DEG_SCF_FBW7_1

Location: 1177:1183

E3 ligase: FBXW7

DEGRON score: 0.9976

ASA_SCORE: 85.2571

COIL: 0.9737

CONS_SCORE: 0.7385

DSS_SCORE: 0.6738

HELIX: 0.0146

FCONS_SCORE: 1.374

RIG_SCORE: 0.5515

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1174C	TCGA-BF-A1PZ	SKCM	TCGA	PGTPPAS	DEG_SCF_FBW7_1	0.25
p.G1174C	DO50279	SKCM	ICGC	PGTPPAS	DEG_SCF_FBW7_1	0.25
p.P1186S	DO229453	SKCA	ICGC	PGTPPAS	DEG_SCF_FBW7_1	0.25
p.P1180L	SIDM00617	Hepatocellular Carcinoma	GDSC	PGTPPAS	DEG_SCF_FBW7_1	0.7582
p.P1180L	JHH-2	liver	COSMIC	PGTPPAS	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15788	Nuclear receptor coactivator 1	DEG_SCF_FBW7_1	1177:1183	PGTPPAS	FBXW7	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons