DegronMD

Uniprot ID: Q15788

Source protein: Nuclear receptor coactivator 1

Source gene: NCOA1

Class: CBL_PTK

Location: 527:537

E3 ligase: CBL

DEGRON score: 0.916

ASA_SCORE: 89.4545

COIL: 0.9205

CONS_SCORE: 0.5126

DSS_SCORE: 0.4786

HELIX: 0.0493

FCONS_SCORE: 0.9456

RIG_SCORE: 0.6997

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S540Y	TCGA-06-5416	GBM	TCGA	NNNNRSYSNIP	CBL_PTK	0.25
p.S540Y	DO10880	GBM	ICGC	NNNNRSYSNIP	CBL_PTK	0.25
p.N545D	TCGA-CV-7097	HNSC	TCGA	NNNNRSYSNIP	CBL_PTK	0.1111
p.N545D	DO14886	HNSC	ICGC	NNNNRSYSNIP	CBL_PTK	0.1111
p.P518S	TCGA-CV-7568	HNSC	TCGA	NNNNRSYSNIP	CBL_PTK	0.0833
p.P518S	DO14160	HNSC	ICGC	NNNNRSYSNIP	CBL_PTK	0.0833
p.V519I	TCGA-DK-A3WW	BLCA	TCGA	NNNNRSYSNIP	CBL_PTK	0.1111
p.V519I	DO481	BLCA	ICGC	NNNNRSYSNIP	CBL_PTK	0.1111
p.V519I	SIDM01107	Melanoma	GDSC	NNNNRSYSNIP	CBL_PTK	0.1111
p.V519I	ACH-000465	Skin Cancer	CCLE	NNNNRSYSNIP	CBL_PTK	0.1111
p.V519I	SK-MEL-1	skin	COSMIC	NNNNRSYSNIP	CBL_PTK	0.1111
p.R531Q	TCGA-EO-A22X	UCEC	TCGA	NNNNRSYSNIP	CBL_PTK	0.6218
p.R531Q	DO43907	UCEC	ICGC	NNNNRSYSNIP	CBL_PTK	0.6218
p.N527D	TCGA-PK-A5HB	ACC	TCGA	NNNNRSYSNIP	CBL_PTK	0.5821
p.E546K	DO224768	BRCA	ICGC	NNNNRSYSNIP	CBL_PTK	0.0833
p.N535S	DO222762	COCA	ICGC	NNNNRSYSNIP	CBL_PTK	0.5958
p.S517T	DO229540	UTCA	ICGC	NNNNRSYSNIP	CBL_PTK	0.5
p.S534A	SIDM02026	Colorectal Carcinoma	GDSC	NNNNRSYSNIP	CBL_PTK	0.7588
p.P537S	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	NNNNRSYSNIP	CBL_PTK	0.6752
p.P537S	ACH-001363	Lung Cancer	CCLE	NNNNRSYSNIP	CBL_PTK	0.6752
p.P537S	NCI-H2135	lung	COSMIC	NNNNRSYSNIP	CBL_PTK	0.6752
p.Y533D	SIDM00568	Gastric Carcinoma	GDSC	NNNNRSYSNIP	CBL_PTK	0.7325
p.Y533D	OCUM-1	stomach	COSMIC	NNNNRSYSNIP	CBL_PTK	0.7325
p.R541W	SNU-175	large_intestine	COSMIC	NNNNRSYSNIP	CBL_PTK	0.2222
p.L539P	NB13	autonomic_ganglia	COSMIC	NNNNRSYSNIP	CBL_PTK	0.2778
p.S531L	NCI-H1944	lung	COSMIC	NNNNRSYSNIP	CBL_PTK	0.7667
p.L539R	HCC2998	large_intestine	COSMIC	NNNNRSYSNIP	CBL_PTK	0.2778
p.S517F	MKN7	stomach	COSMIC	NNNNRSYSNIP	CBL_PTK	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15788	Nuclear receptor coactivator 1	CBL_PTK	527:537	NNNNRSYSNIP	CBL	0.916	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NNNNRSYSNIP

Degron related mutations and impact score

Drug responses associated with NCOA1 mutations

All proteins holding degron of NNNNRSYSNIP