DegronMD - O95817(BAG3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T285M	TCGA-13-0760	OV	TCGA	ARSST	DEG_SPOP_SBC_1	281:285	Mutation altering degron motif	0.8534
p.T285M	DO28541	OV	ICGC	ARSST	DEG_SPOP_SBC_1	281:285	Mutation altering degron motif	0.8534
p.R276L	TCGA-44-3398	LUAD	TCGA	ARSST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1944
p.R276L	DO25030	LUAD	ICGC	ARSST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1944
p.R294C	TCGA-AA-3848	COAD	TCGA	ARSST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.0833
p.R294C	DO9740	COAD	ICGC	ARSST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.0833
p.R294H	TCGA-AP-A0LM	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.0833
p.R294H	DO43306	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.0833
p.P292L	TCGA-B5-A11O	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1389
p.P292L	DO41650	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1389
p.A401T	TCGA-DF-A2KU	UCEC	TCGA	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation rewiring degron network	0.3056
p.A401T	DO223286	UCEC	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation rewiring degron network	0.3056
p.P407L	DO228483	BRCA	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation altering degron motif	0.7582
p.P407L	DO229013	COCA	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation altering degron motif	0.7582
p.P407L	DO229016	COCA	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation altering degron motif	0.7582
p.P407L	DO229346	LAML	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation altering degron motif	0.7582
p.P407L	DO231140	LAML	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation altering degron motif	0.7582
p.P407L	DO52365	LUSC	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation altering degron motif	0.7582
p.P407L	DO231075	LUSC	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation altering degron motif	0.7582
p.E414K	DO222518	ESCA	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation rewiring degron network	0.1944
p.E414K	NCI-H2172	lung	COSMIC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation rewiring degron network	0.1944
p.S274L	DO222532	MELA	ICGC	ARSST	DEG_SPOP_SBC_1	281:285	Mutation blocking phosphorylation signal	0.5833
p.P410A	DO32904	PACA	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation rewiring degron network	0.3056
p.P410A	SIDM00965	Small Cell Lung Carcinoma	GDSC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation rewiring degron network	0.3056
p.P410A	ACH-000800	Lung Cancer	CCLE	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation rewiring degron network	0.3056
p.P410A	NCI-H446	lung	COSMIC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation rewiring degron network	0.3056
p.P286T	SIDM02054	Esophageal Carcinoma	GDSC	ARSST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.3056
p.R276Q	SIDM01079	Melanoma	GDSC	ARSST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1944
p.R276Q	SH-4	skin	COSMIC	ARSST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1944
p.P417Q	SIDM00333	Endometrial Carcinoma	GDSC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation rewiring degron network	0.1111
p.P417Q	ACH-000988	Endometrial/Uterine Cancer	CCLE	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation rewiring degron network	0.1111
p.P417Q	MFE-319	endometrium	COSMIC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation rewiring degron network	0.1111
p.A405T	SIDM00685	Glioblastoma	GDSC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation altering degron motif	0.6028
p.A405T	ACH-000819	Brain Cancer	CCLE	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation altering degron motif	0.6028
p.A405T	LN-18	central nervous system	COSMIC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation altering degron motif	0.6028
p.G411R	ACH-000561	Esophageal Cancer	CCLE	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation rewiring degron network	0.2778
p.G411R	T-T	oesophagus	COSMIC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation rewiring degron network	0.2778
p.A273T	ACH-001610	Brain Cancer	CCLE	ARSST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1111
p.S289P	ACH-001610	Brain Cancer	CCLE	ARSST	DEG_SPOP_SBC_1	281:285	Mutation blocking phosphorylation signal	0.6667
p.G411V	ACH-001853	Bile Duct Cancer	CCLE	PAEATPPK	DEG_SCF_SKP2-CKS1_1	402:409	Mutation rewiring degron network	0.2778
p.E277V	ACH-002396	Bone Cancer	CCLE	ARSST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.2222
p.E277V	Sarc9371	bone	COSMIC	ARSST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.2222

Kaplan plot for BAG3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BAG3

UniProt ID: O95817

Entrez ID: 9531

Protein name: BAG family molecular chaperone regulator 3 (BAG-3) (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for BAG3 in