DegronMD

Uniprot ID: O95817

Source protein: BAG family molecular chaperone regulator 3

Source gene: BAG3

Class: DEG_SCF_SKP2-CKS1_1

Location: 402:409

E3 ligase: SKP2,CSK1

DEGRON score: 0.9945

ASA_SCORE: 103.3625

COIL: 0.972

CONS_SCORE: 0.3763

DSS_SCORE: 0.7851

HELIX: 0.0159

FCONS_SCORE: 1.0426

RIG_SCORE: 0.5597

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A401T	TCGA-DF-A2KU	UCEC	TCGA	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.3056
p.A401T	DO223286	UCEC	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.3056
p.P407L	DO228483	BRCA	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P407L	DO229013	COCA	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P407L	DO229016	COCA	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P407L	DO229346	LAML	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P407L	DO231140	LAML	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P407L	DO52365	LUSC	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.7582
p.P407L	DO231075	LUSC	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.7582
p.E414K	DO222518	ESCA	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.1944
p.E414K	NCI-H2172	lung	COSMIC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.1944
p.P410A	DO32904	PACA	ICGC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.3056
p.P410A	SIDM00965	Small Cell Lung Carcinoma	GDSC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.3056
p.P410A	ACH-000800	Lung Cancer	CCLE	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.3056
p.P410A	NCI-H446	lung	COSMIC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.3056
p.P417Q	SIDM00333	Endometrial Carcinoma	GDSC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.1111
p.P417Q	ACH-000988	Endometrial/Uterine Cancer	CCLE	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.1111
p.P417Q	MFE-319	endometrium	COSMIC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.1111
p.A405T	SIDM00685	Glioblastoma	GDSC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.6028
p.A405T	ACH-000819	Brain Cancer	CCLE	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.6028
p.A405T	LN-18	central_nervous_system	COSMIC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.6028
p.G411R	ACH-000561	Esophageal Cancer	CCLE	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.2778
p.G411R	T-T	oesophagus	COSMIC	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.2778
p.G411V	ACH-001853	Bile Duct Cancer	CCLE	PAEATPPK	DEG_SCF_SKP2-CKS1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95817	BAG family molecular chaperone regulator 3	DEG_SCF_SKP2-CKS1_1	402:409	PAEATPPK	SKP2,CSK1	0.9945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PAEATPPK

Degron related mutations and impact score

Drug responses associated with BAG3 mutations

All proteins holding degron of PAEATPPK