DegronMD

Uniprot ID: O95817

Source protein: BAG family molecular chaperone regulator 3

Source gene: BAG3

Class: DEG_SPOP_SBC_1

Location: 281:285

E3 ligase: SPOP

DEGRON score: 0.9272

ASA_SCORE: 94.38

COIL: 0.9492

CONS_SCORE: 0.2795

DSS_SCORE: 0.7734

HELIX: 0.0274

FCONS_SCORE: 0.8386

RIG_SCORE: 0.499

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T285M	TCGA-13-0760	OV	TCGA	ARSST	DEG_SPOP_SBC_1	0.8534
p.T285M	DO28541	OV	ICGC	ARSST	DEG_SPOP_SBC_1	0.8534
p.R276L	TCGA-44-3398	LUAD	TCGA	ARSST	DEG_SPOP_SBC_1	0.1944
p.R276L	DO25030	LUAD	ICGC	ARSST	DEG_SPOP_SBC_1	0.1944
p.R294C	TCGA-AA-3848	COAD	TCGA	ARSST	DEG_SPOP_SBC_1	0.0833
p.R294C	DO9740	COAD	ICGC	ARSST	DEG_SPOP_SBC_1	0.0833
p.R294H	TCGA-AP-A0LM	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	0.0833
p.R294H	DO43306	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	0.0833
p.P292L	TCGA-B5-A11O	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	0.1389
p.P292L	DO41650	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	0.1389
p.S274L	DO222532	MELA	ICGC	ARSST	DEG_SPOP_SBC_1	0.5833
p.P286T	SIDM02054	Esophageal Carcinoma	GDSC	ARSST	DEG_SPOP_SBC_1	0.3056
p.R276Q	SIDM01079	Melanoma	GDSC	ARSST	DEG_SPOP_SBC_1	0.1944
p.R276Q	SH-4	skin	COSMIC	ARSST	DEG_SPOP_SBC_1	0.1944
p.A273T	ACH-001610	Brain Cancer	CCLE	ARSST	DEG_SPOP_SBC_1	0.1111
p.S289P	ACH-001610	Brain Cancer	CCLE	ARSST	DEG_SPOP_SBC_1	0.6667
p.E277V	ACH-002396	Bone Cancer	CCLE	ARSST	DEG_SPOP_SBC_1	0.2222
p.E277V	Sarc9371	bone	COSMIC	ARSST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95817	BAG family molecular chaperone regulator 3	DEG_SPOP_SBC_1	281:285	ARSST	SPOP	0.9272	More...
P46019	Phosphorylase b kinase regulatory subunit alpha, liver isoform	DEG_SPOP_SBC_1	1037:1041	ARSST	SPOP	0.6157	More...
Q15788	Nuclear receptor coactivator 1	DEG_SPOP_SBC_1	401:405	ARSST	SPOP	0.9779	More...
Q5T619	Zinc finger protein 648	DEG_SPOP_SBC_1	486:490	ARSST	SPOP	0.9232	More...
Q96BA8	Cyclic AMP-responsive element-binding protein 3-like protein 1	DEG_SPOP_SBC_1	235:239	ARSST	SPOP	0.7129	More...
Q96PU5	E3 ubiquitin-protein ligase NEDD4-like	DEG_SPOP_SBC_1	363:367	ARSST	SPOP	0.9797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons