DegronMD

Uniprot ID: Q5T619

Source protein: Zinc finger protein 648

Source gene: ZNF648

Class: DEG_SPOP_SBC_1

Location: 486:490

E3 ligase: SPOP

DEGRON score: 0.9232

ASA_SCORE: 73.32

COIL: 0.7184

CONS_SCORE: 1

DSS_SCORE: 0.3169

HELIX: 0.1294

FCONS_SCORE: 1.0555

RIG_SCORE: 0.7437

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A484T	TCGA-90-7964	LUSC	TCGA	ARSST	DEG_SPOP_SBC_1	0.2778
p.A484T	DO27046	LUSC	ICGC	ARSST	DEG_SPOP_SBC_1	0.2778
p.H498N	TCGA-91-6829	LUAD	TCGA	ARSST	DEG_SPOP_SBC_1	0.1111
p.H498N	DO23564	LUAD	ICGC	ARSST	DEG_SPOP_SBC_1	0.1111
p.S489L	TCGA-BR-8081	STAD	TCGA	ARSST	DEG_SPOP_SBC_1	0.7667
p.S489L	TCGA-EE-A3AE	SKCM	TCGA	ARSST	DEG_SPOP_SBC_1	0.7667
p.S489L	DO220900	MELA	ICGC	ARSST	DEG_SPOP_SBC_1	0.7667
p.S489L	DO229456	SKCA	ICGC	ARSST	DEG_SPOP_SBC_1	0.7667
p.S489L	DO37802	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	0.7667
p.S489L	DO38795	STAD	ICGC	ARSST	DEG_SPOP_SBC_1	0.7667
p.S489L	SIDM01060	Melanoma	GDSC	ARSST	DEG_SPOP_SBC_1	0.7667
p.S489L	ACH-000882	Skin Cancer	CCLE	ARSST	DEG_SPOP_SBC_1	0.7667
p.S489L	IGR-1	skin	COSMIC	ARSST	DEG_SPOP_SBC_1	0.7667
p.R487S	TCGA-D3-A2JK	SKCM	TCGA	ARSST	DEG_SPOP_SBC_1	0.6316
p.R487S	DO37619	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	0.6316
p.P477S	TCGA-DA-A1I0	SKCM	TCGA	ARSST	DEG_SPOP_SBC_1	0.0833
p.P477S	TCGA-DA-A3F8	SKCM	TCGA	ARSST	DEG_SPOP_SBC_1	0.0833
p.P477S	TCGA-W3-A824	SKCM	TCGA	ARSST	DEG_SPOP_SBC_1	0.0833
p.P477S	DO37719	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	0.0833
p.P477S	DO37418	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	0.0833
p.P477S	DO51271	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	0.0833
p.C481Y	TCGA-EO-A22U	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	0.1944
p.C481Y	DO43755	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	0.1944
p.G482V	TCGA-ER-A19P	SKCM	TCGA	ARSST	DEG_SPOP_SBC_1	0.2222
p.G482V	DO47623	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	0.2222
p.R493W	TCGA-FU-A3HZ	CESC	TCGA	ARSST	DEG_SPOP_SBC_1	0.25
p.R493W	DO6308	CESC	ICGC	ARSST	DEG_SPOP_SBC_1	0.25
p.R493W	SIDM01951	Colorectal Carcinoma	GDSC	ARSST	DEG_SPOP_SBC_1	0.25
p.T479M	TCGA-G4-6628	COAD	TCGA	ARSST	DEG_SPOP_SBC_1	0.1389
p.T479M	DO10132	COAD	ICGC	ARSST	DEG_SPOP_SBC_1	0.1389
p.T479M	DO25847	LUAD	ICGC	ARSST	DEG_SPOP_SBC_1	0.1389
p.T479M	DO51496	PACA	ICGC	ARSST	DEG_SPOP_SBC_1	0.1389
p.T479M	SIDM00705	Non-Cancerous	GDSC	ARSST	DEG_SPOP_SBC_1	0.1389
p.T479M	SIDM00706	Small Cell Lung Carcinoma	GDSC	ARSST	DEG_SPOP_SBC_1	0.1389
p.G500R	DO218550	BTCA	ICGC	ARSST	DEG_SPOP_SBC_1	0.0556
p.G500R	ACH-001573	Leukemia	CCLE	ARSST	DEG_SPOP_SBC_1	0.0556
p.R493Q	DO229378	BTCA	ICGC	ARSST	DEG_SPOP_SBC_1	0.25
p.R493Q	DO50328	ESAD	ICGC	ARSST	DEG_SPOP_SBC_1	0.25
p.R493Q	DO233259	GACA	ICGC	ARSST	DEG_SPOP_SBC_1	0.25
p.R493Q	DO222470	MELA	ICGC	ARSST	DEG_SPOP_SBC_1	0.25
p.C478S	DO32893	PACA	ICGC	ARSST	DEG_SPOP_SBC_1	0.1111
p.C481R	DO35242	PACA	ICGC	ARSST	DEG_SPOP_SBC_1	0.1944
p.R487H	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	ARSST	DEG_SPOP_SBC_1	0.7133
p.R487H	ACH-000826	Lung Cancer	CCLE	ARSST	DEG_SPOP_SBC_1	0.7133
p.R487H	CAL-12T	lung	COSMIC	ARSST	DEG_SPOP_SBC_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95817	BAG family molecular chaperone regulator 3	DEG_SPOP_SBC_1	281:285	ARSST	SPOP	0.9272	More...
P46019	Phosphorylase b kinase regulatory subunit alpha, liver isoform	DEG_SPOP_SBC_1	1037:1041	ARSST	SPOP	0.6157	More...
Q15788	Nuclear receptor coactivator 1	DEG_SPOP_SBC_1	401:405	ARSST	SPOP	0.9779	More...
Q5T619	Zinc finger protein 648	DEG_SPOP_SBC_1	486:490	ARSST	SPOP	0.9232	More...
Q96BA8	Cyclic AMP-responsive element-binding protein 3-like protein 1	DEG_SPOP_SBC_1	235:239	ARSST	SPOP	0.7129	More...
Q96PU5	E3 ubiquitin-protein ligase NEDD4-like	DEG_SPOP_SBC_1	363:367	ARSST	SPOP	0.9797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARSST

Degron related mutations and impact score

Drug responses associated with ZNF648 mutations

All proteins holding degron of ARSST